A Study of XPro1595 in Patients With Early Alzheimer's Disease With Biomarkers of Inflammation
← catalyst calendarSponsored by Inmune Bio, Inc. (industry) · INMB — their whole pipeline →.
Phase
Phase 2
Status
Completed
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
207actual
Sites
41
Countries
Australia, Canada, Czechia +5
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-02-28 | actual | When the study began enrolling |
| Primary completion | 2025-05-12 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-05-12 | actual | The whole study's end, after follow-up |
| First posted | 2022-04-08 | actual | When this record first appeared on the registry |
| Results posted | 2026-06-29 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-06-29 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Alzheimer Disease
- Dementia
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Tauopathies
- Neurodegenerative Diseases
- Neurocognitive Disorders
- Mental Disorders
- Mild Cognitive Impairment
Interventions
- Drug: XPro1595 — also filed as INB03/XPro™, XENP1595, DN-TNF
- Drug: Placebo — also filed as Matching Placebo
Primary outcome
what the primary-completion date above is the date OFChange in Early and Mild Alzheimer's Cognitive Composite (EMACC)
measured 24 Weeks
Posted documents
hosted by the registry — we link, never re-serveStudy Protocol and Statistical Analysis Planposted 2024-05-13 · 9.1 MB · Prot_SAP_000.pdf
Publications
- PMID 16705109 — cited as background
- PMID 21239393 — cited as background
- PMID 27470609 — cited as background
- PMID 22966039 — cited as background
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
Permalink · INMB's whole pipeline · Catalyst calendar · Every registered study · What changed