Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC
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Phase
Phase 3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · Single · Treatment
Enrollment
760actual
Sites
171
Countries
Belgium, Brazil, Canada +19
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-03-28 | actual | When the study began enrolling |
| Primary completion | 2026-02-23 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2027-02-26 | estimated | The whole study's end, after follow-up |
| First posted | 2022-03-31 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-13 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Hepatocellular Carcinoma
Interventions
- Drug: Tremelimumab — also filed as MEDI1123
- Drug: Durvalumab — also filed as MEDI4736
- Procedure: Transarterial Chemoembolization (TACE) — also filed as DEB-TACE and cTACE
- Drug: Lenvatinib — also filed as Lenvima
Primary outcome
what the primary-completion date above is the date OFProgression Free Survival (PFS) for Arm A vs Arm C
measured Approximately 5 years
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