A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
← catalyst calendarSponsored by Jazz Pharmaceuticals (industry) · JAZZ — their whole pipeline →. With BeOne Medicines LTD, BeOne Pharmaceutical Co., Ltd..
Phase
Phase 3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · None · Treatment
Enrollment
920actual
Sites
227
Countries
Argentina, Australia, Belgium +30
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2021-12-02 | actual | When the study began enrolling |
| Primary completion | 2026-07-31 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2027-07-31 | estimated | The whole study's end, after follow-up |
| First posted | 2021-12-09 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-17 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Gastric Neoplasms
- Gastroesophageal Adenocarcinoma
- Esophageal Adenocarcinoma
Interventions
- Drug: Zanidatamab — also filed as ZW25, JZP598, ZIIHERA®
- Drug: Tislelizumab
- Drug: Trastuzumab — also filed as Herceptin®
- Drug: Capecitabine
- Drug: Oxaliplatin
- Drug: Cisplatin
- Drug: 5-Fluorouracil
Primary outcomes
what the primary-completion date above is the date OFProgression-free survival (PFS) by BICR
measured Up to 2.5 years
Overall survival
measured Up to 3.5 years
Publications
- PMID 42202319 — linked by the registry
- PMID 41324998 — linked by the registry
- PMID 40341124 — linked by the registry
- PMID 36000541 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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