ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
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Phase
Phase 3
Status
Completed
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
6,385actual
Sites
1,071
Countries
Argentina, Australia, Belgium +35
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2021-08-30 | actual | When the study began enrolling |
| Primary completion | 2026-06-09 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-06-09 | actual | The whole study's end, after follow-up |
| First posted | 2021-08-26 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-28 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Cardiovascular Risk
- Chronic Kidney Disease
- Inflammation
Interventions
- Drug: Ziltivekimab B
- Drug: Ziltivekimab C
- Drug: Placebo (Ziltivekimab B)
- Drug: Placebo (Ziltivekimab C)
Primary outcome
what the primary-completion date above is the date OFTime to first occurrence of 3-point Major Adverse Cardiovascular Event (MACE), a composite endpoint consisting of: Cardiovascular (CV) death, non-fatal Myocardial Infarction (MI) and non-fatal stroke
measured From randomisation (month 0) to end-of-study (up to 48 months)
Publications
- PMID 41329869 — linked by the registry
- PMID 40318255 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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