Safety, Pharmacokinetics and Clinical Activity of AZD0171 in Combination With Durvalumab and Chemotherapy in Locally Advanced or Metastatic Solid Tumours
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Phase
Phase 2
Status
Active, not recruiting
Study type
Interventional
Design
Na · None · Treatment
Enrollment
126actual
Sites
34
Countries
Canada, South Korea, Spain +1
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2021-12-10 | actual | When the study began enrolling |
| Primary completion | 2024-10-07 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-11-30 | estimated | The whole study's end, after follow-up |
| First posted | 2021-08-11 | actual | When this record first appeared on the registry |
| Results posted | 2025-11-26 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-08-19 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Locally Advanced or Metastatic Solid Tumours
Interventions
- Drug: AZD0171 — also filed as MSC-1
- Drug: Durvalumab — also filed as MEDI4736
- Drug: Gemcitabine
- Drug: Nab-paclitaxel
Primary outcomes
what the primary-completion date above is the date OFNumber of Participants With Adverse Events (AEs), Immune Mediated AEs (imAEs) and Serious AEs (SAEs)
measured From Cycle 1 Day 1 (each cycle was 28 days in length) until Day 90 (post last dose of study intervention), up to 34 months
Overall Survival at 12 Months (OS-12)
measured At 12 months
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2024-05-03 · 3.7 MB · Prot_000.pdf
Statistical Analysis Planposted 2024-09-26 · 2.6 MB · SAP_001.pdf
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