Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
← catalyst calendarNCT04822181 · readout in 980 d
Sponsored by Novo Nordisk A/S (industry) · NVO — their whole pipeline →.
Phase
Phase 3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · Double · Treatment
Enrollment
1,205actual
Sites
557
Countries
Argentina, Australia, Austria +36
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2021-04-01 | actual | When the study began enrolling |
| Primary completion | 2029-04-25 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2029-04-25 | estimated | The whole study's end, after follow-up |
| First posted | 2021-03-30 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-08-04 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Non-alcoholic Steatohepatitis
Interventions
- Drug: Semaglutide
- Drug: Placebo
Primary outcomes
what the primary-completion date above is the date OFPart 1: Resolution of steatohepatitis and no worsening of liver fibrosis (Yes/No)
measured From randomisation (week 0) to week 72
Part 1: Improvement in liver fibrosis and no worsening of steatohepatitis (Yes/No)
measured From randomisation (week 0) to week 72
Part 2: Cirrhosis-free survival (Yes/No)
measured From randomisation (week 0) to week 240
Publications
- PMID 39412509 — reports results
- PMID 40305708 — linked by the registry
- PMID 39392766 — linked by the registry
- PMID 36738088 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
Permalink · NVO's whole pipeline · Catalyst calendar · Every registered study · What changed