Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
← catalyst calendarSponsored by Boston Scientific Corporation (industry) · BSX — their whole pipeline →. With National PERT Consortium, Inc., University Medical Center Mainz.
Phase
Phase 4
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · Single · Treatment
Enrollment
544actual
Sites
60
Countries
Austria, France, Germany +6
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2021-08-02 | actual | When the study began enrolling |
| Primary completion | 2025-07-31 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | Aug 2026 | estimated | The whole study's end, after follow-up |
| First posted | 2021-03-10 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-01 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Pulmonary Embolism
Interventions
- Drug: Anticoagulation with heparin — also filed as heparin, LMWH, UFH, anticoag, antiplatelet
- Device: EkoSonicTM Endovascular System — also filed as EKOS, USCDT, CDT, thrombolysis, fibrinolysis
Primary outcomes
what the primary-completion date above is the date OFPE-related mortality
measured Within seven days of randomization
PE recurrence
measured Within seven days of randomization
Cardiorespiratory decompensation or collapse
measured Within seven days of randomization
Publications
- PMID 29348184 — cited as background
- PMID 24917641 — cited as background
- PMID 26867832 — cited as background
- PMID 21422387 — cited as background
- PMID 27174887 — cited as background
- PMID 24716681 — cited as background
- PMID 27718446 — cited as background
- PMID 24226805 — cited as background
- PMID 26315743 — cited as background
- PMID 25856269 — cited as background
- PMID 30025734 — cited as background
- PMID 22172434 — cited as background
- PMID 21670242 — cited as background
- PMID 8204123 — cited as background
- PMID 15842354 — cited as background
- PMID 20620859 — cited as background
- PMID 32427324 — cited as background
- PMID 23295778 — cited as background
- PMID 15148278 — cited as background
- PMID 19326189 — cited as background
- PMID 12091180 — cited as background
- PMID 20025645 — cited as background
- PMID 1593914 — cited as background
- PMID 26780747 — cited as background
- PMID 31504429 — cited as background
- PMID 41910345 — linked by the registry
- PMID 35588898 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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