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A Dose Escalation/Expansion Study of ERAS-601 in Patients With Advanced or Metastatic Solid Tumors

← catalyst calendar

NCT04670679

Sponsored by Erasca, Inc. (industry) · ERAS — their whole pipeline →.

Phase
Phase 1
Status
Active, not recruiting
Study type
Interventional
Design
Non randomized · None · Treatment
Enrollment
90actual
Sites
14
Countries
Australia, United States

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis
DateFiledBasisWhat it is
Start2020-12-15actualWhen the study began enrolling
Primary completion2026-02-01actualThe date the last participant is measured for the primary outcome — the readout window
Study completionJun 2026estimatedThe whole study's end, after follow-up
First posted2020-12-17actualWhen this record first appeared on the registry
Results postedWhen the sponsor posted results to the registry
Record updated2026-03-25actualThe sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Condition

  • Advanced or Metastatic Solid Tumors

Interventions

  • Drug: ERAS-601
  • Drug: Cetuximab — also filed as Erbitux
  • Drug: Pembrolizumab — also filed as Keytruda

Primary outcomes

what the primary-completion date above is the date OF
Dose Limiting Toxicities (DLT)
measured Study Day 1 up to Day 29
Maximum tolerated dose (MTD)
measured Study Day 1 up to Day 29
Recommended dose (RD)
measured Study Day 1 up to Day 29
Adverse Events
measured Assessed up to 24 months from time of first dose
Plasma concentration (Cmax)
measured Study Day 1 up to Day 29
Time to achieve Cmax (Tmax)
measured Study Day 1 up to Day 29
Area under the curve
measured Study Day 1 up to Day 29
Half-life
measured Study Day 1 up to Day 29

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