An Open Label Study Evaluating the Efficacy and Safety of Etrumadenant (AB928) Based Treatment Combinations in Participants With Metastatic Colorectal Cancer.
← catalyst calendarSponsored by Arcus Biosciences, Inc. (industry) · RCUS — their whole pipeline →. With Gilead Sciences.
Phase
Phase 1/2
Status
Completed
Study type
Interventional
Design
Randomized · Single · Treatment
Enrollment
227actual
Sites
44
Countries
France, Italy, South Korea +3
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2021-05-10 | actual | When the study began enrolling |
| Primary completion | 2025-09-05 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-09-05 | actual | The whole study's end, after follow-up |
| First posted | 2020-12-09 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-10-20 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Metastatic Colorectal Cancer
Interventions
- Drug: AB680
- Drug: Etrumadenant — also filed as AB928
- Drug: Zimberelimab — also filed as AB122
- Drug: Bevacizumab
- Drug: m-FOLFOX-6 regimen
- Drug: Regorafenib
Primary outcomes
what the primary-completion date above is the date OFCohort A and B - Progression-free Survival (PFS)
measured From randomization until death from any cause (up to approximately 3-7 years)
Cohort C - Objective Response Rate (ORR)
measured From randomization until death from any cause (up to approximately 3-7 years)
Number of Participants With Treatment-emergent Adverse Events
measured Up to approximately 10 Months
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