A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
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Phase
Phase 3
Status
Completed
Study type
Interventional
Design
Randomized · Double · Treatment
Enrollment
13,299actual
Sites
635
Countries
Argentina, Australia, Austria +28
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2020-05-29 | actual | When the study began enrolling |
| Primary completion | 2025-06-12 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-06-12 | actual | The whole study's end, after follow-up |
| First posted | 2020-02-05 | actual | When this record first appeared on the registry |
| Results posted | 2026-07-08 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-07-08 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Type 2 Diabetes Mellitus
Interventions
- Drug: Tirzepatide — also filed as LY3298176
- Drug: Dulaglutide — also filed as LY2189265
Primary outcome
what the primary-completion date above is the date OFNumber of Participants From Randomization to First Occurrence of Death From MACE-3 [Composite Endpoint of Major Adverse Cardiovascular Events Death From Cardiovascular Causes, Myocardial Infarction (MI) or Stroke]
measured From randomization (week 0) up to week 259
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2024-04-16 · 3.6 MB · Prot_000.pdf
Statistical Analysis Planposted 2025-07-24 · 1.5 MB · SAP_001.pdf
Publications
- PMID 41903177 — linked by the registry
- PMID 41406444 — linked by the registry
- PMID 40746703 — linked by the registry
- PMID 35949358 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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