Single Ascending Dose Study in Participants With LCA10
← catalyst calendarSponsored by Editas Medicine, Inc. (industry) · EDIT — their whole pipeline →.
Phase
Phase 1/2
Status
Unknown status
Study type
Interventional
Design
Non randomized · None · Treatment
Enrollment
34estimated
Sites
5
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2019-09-26 | actual | When the study began enrolling |
| Primary completion | 2025-05-23 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-05-23 | estimated | The whole study's end, after follow-up |
| First posted | 2019-03-13 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2022-12-05 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Leber Congenital Amaurosis 10
- Inherited Retinal Dystrophies
- Eye Diseases, Hereditary
- Retinal Disease
- Retinal Degeneration
- Vision Disorders
- Eye Disorders Congenital
Intervention
- Drug: EDIT-101
Primary outcomes
what the primary-completion date above is the date OFFrequency of Adverse Events related to EDIT-101
measured 1 year
Number of participants experiencing procedural related adverse events
measured 1 year
Incidence of dose limiting toxicities
measured 1 year
Publications
- PMID 38709228 — linked by the registry
- PMID 34629400 — linked by the registry
- PMID 33497524 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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