A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy
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Phase
Phase 3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
406actual
Sites
162
Countries
Australia, Belgium, Croatia +15
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2018-12-11 | actual | When the study began enrolling |
| Primary completion | 2023-08-07 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | Jul 2026 | estimated | The whole study's end, after follow-up |
| First posted | 2018-12-04 | actual | When this record first appeared on the registry |
| Results posted | 2024-07-03 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-04-20 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Immunoglobulin A Nephropathy
Interventions
- Drug: sparsentan — also filed as RE-021
- Drug: irbesartan — also filed as Irbesartan Tablets USP
- Drug: Dapagliflozin
Primary outcome
what the primary-completion date above is the date OFPercent Change From Baseline in the Urine Protein/Creatinine (UP/C) at Week 36
measured Baseline (Day 1) and at Week 36
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2022-11-22 · 2.3 MB · Prot_000.pdf
Statistical Analysis Planposted 2021-07-21 · 853 KB · SAP_001.pdf
Publications
- PMID 41428405 — linked by the registry
- PMID 38299639 — linked by the registry
- PMID 37931634 — linked by the registry
- PMID 37254256 — linked by the registry
- PMID 37015244 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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