Study of Durvalumab Given With Chemotherapy, Durvalumab in Combination With Tremelimumab Given With Chemotherapy, or Chemotherapy in Patients With Unresectable Urothelial Cancer
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Phase
Phase 3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · None · Treatment
Enrollment
1,246actual
Sites
222
Countries
Argentina, Australia, Brazil +19
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2018-09-27 | actual | When the study began enrolling |
| Primary completion | 2026-06-01 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2027-06-01 | estimated | The whole study's end, after follow-up |
| First posted | 2018-09-24 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-05-28 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Unresectable Locally Advanced Urothelial Cancer
- Metastatic Urothelial Cancer
Interventions
- Drug: Durvalumab — also filed as MEDI4736
- Drug: Tremelimumab
- Drug: Cisplatin + Gemcitabine
- Drug: Carboplatin + Gemcitabine
Primary outcome
what the primary-completion date above is the date OFOverall Survival (OS)
measured approximately 5 years
Publications
- PMID 39094286 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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