A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma
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Phase
Phase 2/3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
714actual
Sites
127
Countries
Argentina, Australia, Austria +22
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2018-04-11 | actual | When the study began enrolling |
| Primary completion | 2021-01-25 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2030-12-15 | estimated | The whole study's end, after follow-up |
| First posted | 2018-03-20 | actual | When this record first appeared on the registry |
| Results posted | 2022-03-29 | actual | When the sponsor posted results to the registry |
| Record updated | 2025-09-09 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Melanoma
Interventions
- Biological: Relatlimab
- Biological: Nivolumab
Primary outcome
what the primary-completion date above is the date OFProgression Free Survival (PFS)
measured From randomization to date of first documented tumor progression or death (up to approximately 33 months)
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2020-11-23 · 30.7 MB · Prot_000.pdf
Statistical Analysis Planposted 2021-10-25 · 838 KB · SAP_001.pdf
Publications
- PMID 41811823 — linked by the registry
- PMID 40940136 — linked by the registry
- PMID 40513285 — linked by the registry
- PMID 39671533 — linked by the registry
- PMID 38320023 — linked by the registry
- PMID 37167764 — linked by the registry
- PMID 36628573 — linked by the registry
- PMID 34986285 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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