A Phase 1 Study Evaluating the Safety, Tolerability and Efficacy of AMG 119 in Subjects With RR SCLC
← catalyst calendarNCT03392064 · readout in 513 d
Sponsored by Amgen (industry) · AMGN — their whole pipeline →.
Phase
Phase 1
Status
Suspended
Study type
Interventional
Design
Na · None · Treatment
Enrollment
6actual
Sites
2
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
Study on enrollment hold, may potentially resume. No active subjects on trial.
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2018-09-10 | actual | When the study began enrolling |
| Primary completion | 2028-01-14 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2028-01-14 | estimated | The whole study's end, after follow-up |
| First posted | 2018-01-05 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-10-15 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Small Cell Lung Cancer
Intervention
- Biological: AMG 119
Primary outcomes
what the primary-completion date above is the date OFIncidence of dose limiting toxicities (DLTs)
measured Up to 5 years
Incidence of treatment-emergent adverse events and treatment-related adverse events
measured Up to 5 years
Incidence of clinically significant changes in vital signs
measured Up to 5 years
Incidence of clinically significant changes in physical examinations
measured Up to 5 years
Incidence of clinically significant changes in clinical laboratory tests
measured Up to 5 years
Publications
- PMID 31215500 — cited as background
- PMID 39897044 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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