Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
← catalyst calendarSponsored by Eli Lilly and Company (industry) · LLY — their whole pipeline →. With NSABP Foundation Inc.
Phase
Phase 3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · None · Treatment
Enrollment
5,637actual
Sites
619
Countries
Argentina, Australia, Austria +35
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2017-07-12 | actual | When the study began enrolling |
| Primary completion | 2020-03-16 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | May 2029 | estimated | The whole study's end, after follow-up |
| First posted | 2017-05-16 | actual | When this record first appeared on the registry |
| Results posted | 2021-04-09 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-04-24 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Breast Cancer
Interventions
- Drug: Abemaciclib — also filed as LY2835219
- Drug: Standard Adjuvant Endocrine Therapy
Primary outcome
what the primary-completion date above is the date OFInvasive Disease Free Survival (IDFS)
measured Baseline to Recurrence or Death from Any Cause (Up to 32 Months)
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2019-09-18 · 2.6 MB · Prot_000.pdf
Statistical Analysis Planposted 2020-06-05 · 1.3 MB · SAP_001.pdf
Publications
- PMID 41110697 — linked by the registry
- PMID 39463748 — linked by the registry
- PMID 39023253 — linked by the registry
- PMID 38194616 — linked by the registry
- PMID 37735004 — linked by the registry
- PMID 36493792 — linked by the registry
- PMID 36342342 — linked by the registry
- PMID 35653145 — linked by the registry
- PMID 35594464 — linked by the registry
- PMID 35384873 — linked by the registry
- PMID 35337972 — linked by the registry
- PMID 35084948 — linked by the registry
- PMID 32954927 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
Permalink · LLY's whole pipeline · Catalyst calendar · Every registered study · What changed