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Obstructive Sleep Apnea trial readouts

registry pull 2026-08-19

Primary-completion dates that listed drug and biotech companies filed with ClinicalTrials.gov for studies in Obstructive Sleep Apnea. They are the sponsor's own estimated windows, revised as a study runs — not announcement dates. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Upcoming readout windows

next 180 days · by month

8 studies across 3 companies, in the next 180 days.

September 2026 1

TickerNameStudyPhaseStatusPrimary completionReadout inUpdated
NYXH.BRNyxoah S.A.Safety and Effectiveness of the Genio® bilAteral Stimulation for Treatment of Complete Concentric CollapsE and OSA.NCT05592002Primary Effectiveness EndpointNot applicableActive, not recruitingSep 2026≤ 41 d2025-09-05

October 2026 3

TickerNameStudyPhaseStatusPrimary completionReadout inUpdated
NYXH.BRNyxoah S.A.A Post-market Clinical Follow up of the Genio® System for the Treatment of Obstructive Sleep Apnea in AdultsNCT04031040Incidence of device-related Serious Adverse Events (SADEs)Not applicableActive, not recruiting2026-10-30in 71 d2026-03-04
RMDResMedRegistry Study on Prescription, Patient Pathways, Therapy Efficacy and Usage of Mandibular Advancement Devices in Obstructive Sleep Apnea - PATT-OSA RegistryNCT03924817observationalChanges of the Apnoea-Hypopnea-Index (AHI) at baseline compared to a follow-up after 3 monthsActive, not recruiting2026-10-31in 72 d2026-08-13
RMDResMedExploration of Current and New Technologies for Accuracy of Diagnosing OSANCT07485582observationalSensitivityNot yet recruitingOct 2026≤ 72 d2026-08-19

November 2026 1

TickerNameStudyPhaseStatusPrimary completionReadout inUpdated
LLYEli Lilly and CompanyA Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or OverweightNCT06649045Change from Baseline in Apnea-Hypopnea Index (AHI)Phase 3Active, not recruitingNov 2026≤ 102 d2025-09-29

December 2026 3

TickerNameStudyPhaseStatusPrimary completionReadout inUpdated
RMDResMedStudy of Min-Max APAP Recommender ToolNCT07400861Mean residual AHINot applicableNot yet recruiting2026-12-01in 103 d2026-02-12
RMDResMedINFORMing Patients With Oximetry Data to Improve MAD EngagementNCT07564310Mean overall patient reported experience measure (PREM) questionnaire scorePhase 4Not yet recruiting2026-12-01in 103 d2026-05-04
RMDResMedData Collection Study to Review Novel Methods for Diagnosing Obstructive Sleep ApneaNCT06930404observationalCorrelation of measurement and obstructive sleep apnea statusRecruiting2026-12-30in 132 d2026-05-19

Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.

Every registered study in Obstructive Sleep Apnea

most recently updated first

111 studies match. Showing the first 100 of 111 studies — page through, or narrow the filters.

TickerNameMarket capStudyPhaseStatusInterventionsConditionsEnrollmentStartPrimary completionReadout inUpdated
RMDResMed$31.7BExploration of Current and New Technologies for Accuracy of Diagnosing OSANCT07485582observationalSensitivityNot yet recruitingDevice: Device A, Device B, Device C, Device D, Device E · Diagnostic test: Screener AObstructive Sleep Apnea90Sep 2026Oct 2026≤ 72 d2026-08-19
RMDResMed$31.7BLong-term Observation of PAP-therapy With Telemonitoring: Telemedicine Registry TelePAPNCT03043716observationalUsage Patterns of PAP therapy with telemonitoring, assessed by data continuously recorded by the device and transferred via telemonitoringCompletedOther: PAP therapy with telemonitoringObstructive Sleep Apnea, Central Sleep Apnea, Mixed Sleep Apnea14,1472017-08-012026-07-31actual2026-08-17
AMGNAmgen$229.9BMaridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) TherapyNCT07226765Change in Apnea-hypopnea Index (AHI) from baseline at Week 52Phase 3RecruitingDrug: Maridebart cafraglutide, PlaceboObstructive Sleep Apnea2502025-11-252027-09-29in 405 d2026-08-14
RMDResMed$31.7BRegistry Study on Prescription, Patient Pathways, Therapy Efficacy and Usage of Mandibular Advancement Devices in Obstructive Sleep Apnea - PATT-OSA RegistryNCT03924817observationalChanges of the Apnoea-Hypopnea-Index (AHI) at baseline compared to a follow-up after 3 monthsActive, not recruitingObstructive Sleep Apnea5002024-02-012026-10-31in 72 d2026-08-13
IXHLIncannex Healthcare Ltd$116MDReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea.NCT07635563Change in AHI4 at the end of each treatment period compared to baselinePhase 2RecruitingDrug: IHL-42X: 2.5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 7.5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 2.5 mg dronabinol + 250 mg acetazolamide, IHL-42X: 5 mg dronabinol + 250 mg acetazolamide, IHL-42X: 7.5 mg dronabinol + 250 mg acetazolamide, IHL-42X: 2.5 mg dronabinol + 375 mg acetazolamide, IHL-42X: 5 mg dronabinol + 375 mg acetazolamide, IHL-42X: 7.5 mg dronabinol + 375 mg acetazolamide, Placebo: Negative controlObstructive Sleep Apnea (OSA)1202026-07-21Apr 2027≤ 253 d2026-08-13
APMDApnimedParallel Arm Trial of AD109 and AD504 In Patients With OSANCT05071612results2026-08-12Change in Apnea-Hypopnea Index (AHI4) From Baseline: Combined AD109 Arms vs. PlaceboPhase 2CompletedDrug: AD109, AD504, Atomoxetine Hydrochloride, PlaceboOSA - Obstructive Sleep Apnea2942021-11-292022-07-20actual2026-08-12
LLYEli Lilly and Company$1.15TA Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or OverweightNCT07369011Percent Change from Baseline in Body WeightPhase 3RecruitingDrug: Eloralintide, PlaceboSleep Apnea, Obstructive, Obesity, Overweight8002026-02-10Mar 2028≤ 589 d2026-08-06
AMGNAmgen$229.9BMaridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure TherapyNCT07225686Change in Apnea-Hypopnea Index (AHI) from baseline at week 52Phase 3RecruitingDrug: Maridebart cafraglutide, PlaceboObesity, Obstructive Sleep Apnea2502025-12-192027-09-29in 405 d2026-08-04
NVONovo Nordisk A/SAMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep ApnoeaNCT07571109Relative change in body weightPhase 3RecruitingDrug: NNC0487-0111, Placebo (matched to NNC0487-0111)Obesity, Overweight, Obstructive Sleep Apnoea3002026-05-052028-06-26in 676 d2026-08-04
LLYEli Lilly and Company$1.15TA Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or OverweightNCT05929079Percent Change from Baseline in Body WeightPhase 3CompletedDrug: Retatrutide, PlaceboType 2 Diabetes, Obesity, Overweight, Obstructive Sleep Apnea1,1522023-07-112026-06-16actual2026-07-30
IXHLIncannex Healthcare Ltd$116MRePOSA-Revealing the Efficacy of IHL-42X Use in Patients With OSANCT06146101Change in apnea-hypopnea index (AHI)Phase 2/3CompletedDrug: IHL-42X Low Dose, IHL-42X High Dose, Placebo, IHL-42X (Optimal Dose), Dronabinol, Acetazolamide, PlaceboObstructive Sleep Apnea1212024-05-022025-05-20actual2026-07-27
LIVNLivaNova$4.4BTreating Obstructive Sleep Apnea Using Targeted Hypoglossal NeurostimulationNCT04950894Rate of response to therapy when compared to no therapy for 6 monthsNot applicableCompletedDevice: Hypoglossal Nerve StimulationObstructive Sleep Apnea, OSA, Apnea, Apnea, Obstructive, Apnea, Obstructive Sleep, Apnea+Hypopnea, Hypopnea, Sleep1072022-02-242024-10-17actual2026-07-17
NVONovo Nordisk A/SAMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep ApnoeaNCT07571005Relative change in body weightPhase 3RecruitingDrug: NNC0487-0111, Placebo (matched to NNC0487-0111)Obesity, Overweight, Obstructive Sleep Apnoea3002026-05-052028-07-12in 692 d2026-07-13
NYXH.BRNyxoah Inc.$46MBi-lateral HGN Therapy in Real-World Patients -Post Approval Research InvestigationNCT07331285observationalChange in Apnea Hypopnea Index (AHI4%)RecruitingDevice: This is a single arm study, all consented and eligible subjects will be implanted with the Genio® System 2.1Obstructive Sleep Apnea229Jun 2026Oct 2028≤ 803 d2026-06-22
LLYEli Lilly and Company$1.15TA Study of Retatrutide (LY3437943) in Participants Who Have Obesity or OverweightNCT05929066Percent Change From Baseline in Body WeightPhase 3CompletedDrug: Retatrutide, PlaceboObesity, Overweight, Osteoarthritis, Knee, Obstructive Sleep Apnea2,3352023-07-102026-04-06actual2026-06-03
INSPInspire Medical Systems, Inc.$1.7BInspire Singapore StudyNCT06540716Inspiratory OverlapNot applicableCompletedDevice: Inspire SystemObstructive Sleep Apnea, OSA, Sleep Apnea442024-07-252025-07-17actual2026-05-22
RMDResMed$31.7BData Collection Study to Review Novel Methods for Diagnosing Obstructive Sleep ApneaNCT06930404observationalCorrelation of measurement and obstructive sleep apnea statusRecruitingOther: facial scans, videos and heart rate variability measurementsObstructive Sleep Apnea (OSA)8002025-09-152026-12-30in 132 d2026-05-19
RMDResMed$31.7BINFORMing Patients With Oximetry Data to Improve MAD EngagementNCT07564310Mean overall patient reported experience measure (PREM) questionnaire scorePhase 4Not yet recruitingDevice: Narval MRD device, MyNarval intervention (Narval CC MAD + O2 ring + MyNarval smartphone application),Obstructive Sleep Apnea (OSA)1202026-06-012026-12-01in 103 d2026-05-04
RMDResMed$31.7BPost Market Clinical Follow up of ResMed Mask SystemsNCT05262439Apnea Hypopnea Index (event/hour)Not applicableRecruitingDevice: New generation CPAP maskObstructive Sleep Apnea5002022-05-26Jun 2027≤ 314 d2026-04-29
RMDResMed$31.7BWhitsundays (Nasal) Singapore External Clinical Study 1 ProtocolNCT05255744Subjective usabilityNot applicableTerminatedsponsor's stated reason: The study was discontinued prior to initiation because startup activities could not be completed within the planned timelines.Device: Positive Airway Pressure (PAP) TherapyObstructive Sleep Apnea302025-03-282025-05-06actual2026-04-27
RMDResMed$31.7BPAP Systems Internal Clinical Studies (ICS)NCT06173050Subjective outcomes parameters scoresNot applicableCompletedDevice: PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi)Obstructive Sleep Apnea302024-06-202024-07-22actual2026-04-24
RMDResMed$31.7BPAP Systems External Clinical Studies (ECS)NCT06562205(usability) Comparison of the usability of an investigational component/s of the PAP system to a comparison component/s of the PAP system and/or Criterion Score of 6Not applicableNot yet recruitingDevice: PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi)Obstructive Sleep Apnea302028-08-012028-10-01in 773 d2026-04-24
NYXH.BRNyxoah S.A.$46MDual-sided Hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea (DREAM)NCT03868618Change in Apnea Hypopnea Index (AHI4%)Not applicableActive, not recruitingDevice: Genio™ systemObstructive Sleep Apnea1152020-10-142024-02-20actual2026-04-14
INSPInspire Medical Systems, Inc.$1.7BInspire UAS High Apnea Hypopnea Index (AHI)/High Body Mass Index (BMI) Post-Approval StudyNCT07113288observationalIncidence of Procedure and/or Device Related Adverse Events (Safety and Tolerability)RecruitingDevice: Inspire® UAS SystemObstructive Sleep Apnea (OSA)702025-07-312032-01-01in 1,960 d2026-03-27
NYXH.BRNyxoah S.A.$46MA Post-market Clinical Follow up of the Genio® System for the Treatment of Obstructive Sleep Apnea in AdultsNCT04031040Incidence of device-related Serious Adverse Events (SADEs)Not applicableActive, not recruitingDevice: Genio® system therapyObstructive Sleep Apnea1102019-09-012026-10-30in 71 d2026-03-04
RMDResMed$31.7BEvaluation of a Wearable PAP Device in a Tethered Configuration for the Treatment of Obstructive Sleep Apnoea.NCT07420140Subjective usability and overnight acceptabilityNot applicableNot yet recruitingDevice: Positive Airway PressureOSA - Obstructive Sleep Apnea15Mar 2026Jun 20262026-02-19
RMDResMed$31.7BStudy of Min-Max APAP Recommender ToolNCT07400861Mean residual AHINot applicableNot yet recruitingDevice: CPAP with min-max recommender tool, CPAP with default settingsObstructive Sleep Apnea (OSA)902026-04-012026-12-01in 103 d2026-02-12
AXSMAxsome Therapeutics, Inc.$11.3BSolriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled StudyNCT04789174results2026-01-26Change From Baseline in the Average of the DSST RBANS Scores at the End of Each Double-blind Treatment PeriodPhase 4CompletedDrug: Solriamfetol, PlaceboExcessive Daytime Sleepiness, Obstructive Sleep Apnea, Impaired Cognitive Function592021-05-172022-09-19actual2026-01-26
MLYSMineralys Therapeutics Inc.$2.3BA Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and HypertensionNCT06785454Placebo-adjusted Change From Baseline in AHI at Week 4Phase 2CompletedDrug: Lorundrostat, PlaceboObstructive Sleep Apnea, Hypertension482025-02-282025-12-17actual2026-01-13
RMDResMed$31.7BEvaluation of a Novel Auto-Adjusting Positive Airway Pressure Algorithm for the Treatment of Obstructive Sleep Apnea Clinical StudyNCT06769607Comparison of the algorithm efficacy (AHI) to a clinically relevant dataNot applicableRecruitingDevice: Investigational algorithm, Control algorithmObstructive Sleep Apnea802025-04-10Dec 20252025-12-02
APMDApnimedParallel Arm Trial of AD109 and Placebo With Patients With OSA (LunAIRo)NCT05811247Change from Baseline in Apnea-Hypopnea Index (AHI)Phase 3CompletedDrug: AD109, PlaceboOSA6602023-08-282025-05-07actual2025-11-21
APMDApnimedParallel-Arm Study to Compare AD109 to Placebo With Patients With OSA (SynAIRgy Study)NCT05813275Change from Baseline in Apnea-Hypopnea Index (AHI)Phase 3CompletedDrug: AD109, PlaceboOSA6462023-09-162025-03-10actual2025-11-21
LLYEli Lilly and Company$1.15TA Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or OverweightNCT06649045Change from Baseline in Apnea-Hypopnea Index (AHI)Phase 3Active, not recruitingDrug: Orforglipron, PlaceboOSA, Overweight or Obesity6002024-10-22Nov 2026≤ 102 d2025-09-29
INSPInspire Medical Systems, Inc.$1.7BEffects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep ApneaNCT04801771Change in intelligence using the Kaufman Brief Intelligence Scale (KBIT-2)Phase 3Active, not recruitingDevice: Inspire Upper Airway Stimulation (UAS) SystemDown Syndrome, Obstructive Sleep Apnea572021-06-242027-02-28in 192 d2025-09-18
INSPInspire Medical Systems, Inc.$1.7BEURO-STIM RegistryNCT06971796observationalApnea Hypopnea Index (AHI)RecruitingDevice: Inspire UAS SystemObstructive Sleep Apnea, Obstructive Sleep Apnea (OSA)1,0002025-05-26Apr 2035≤ 3,175 d2025-09-08
NYXH.BRNyxoah S.A.$46MSafety and Effectiveness of the Genio® bilAteral Stimulation for Treatment of Complete Concentric CollapsE and OSA.NCT05592002Primary Effectiveness EndpointNot applicableActive, not recruitingDevice: Genio SystemSleep Apnea, Obstructive1242022-12-28Sep 2026≤ 41 d2025-09-05
INSPInspire Medical Systems, Inc.$1.7BAdherence and Outcome of Upper Airway Stimulation (UAS) for OSA International RegistryNCT02907398observationalChange in Apnea Hypopnea (AHI) from Baseline to 12-MonthsUnknown statusDevice: Inspire therapy · Other: No interventionObstructive Sleep Apnea5,0002016-10-19Sep 20252025-06-19
NYXH.BRNyxoah S.A.$46MBilatEral Hypoglossal Nerve StimulaTion for TreatmEnt of ObstRuctive SLEEP Apnoea With and Without Complete Concentric CollapseNCT03763682Incidence of serious device-related adverse events recorded during the studyNot applicableTerminatedsponsor's stated reason: The study was terminated due to operational challenges impacting protocol execution across sites.Device: Genio(TM) bilateral hypoglossal nerve stimulation systemObstructive Sleep Apnea422019-01-102021-06-28actual2025-06-06
NYXH.BRNyxoah S.A.$46MAn Extension Study to Assess the Long-term Safety of the Genio® SystemNCT05939141observationalLong-term safetyNot yet recruitingDevice: Genio SystemObstructive Sleep Apnea of Adult39Nov 20252029-07-17in 1,062 d2025-06-04
APMDApnimedContinuation Protocol for Obstructive Sleep Apnea (OSA)NCT06566820Number of Participants With Adverse Events (AES) and Serious Adverse Events (SAEs)Phase 3Enrolling by invitationDrug: Aroxybutynin and AtomoxetineOSA1,2802024-07-032026-06-302025-05-13
LLYEli Lilly and Company$1.15TObstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep ApneaNCT05412004results2025-04-30Change From Baseline in Apnea-Hypopnea Index (AHI)Phase 3CompletedDrug: Tirzepatide, PlaceboObstructive Sleep Apnea, Obesity4692022-06-212024-03-12actual2025-04-30
INSPInspire Medical Systems, Inc.$1.7BPediatric Post-Approval RegistryNCT04457154observationalEvaluation of device and/or procedure related adverse events over timeRecruitingDevice: Inspire Upper Airway Stimulation SystemObstructive Sleep Apnea602021-11-30Dec 2027≤ 498 d2025-02-25
APMDApnimedStudy That Tests AD109 in Patients Taking GLP-1 DrugsNCT06400615Primary Objective (Adverse Events)Phase 2CompletedDrug: AD109OSA402024-05-202024-12-26actual2025-02-19
IXHLIncannex Healthcare Ltd$116MBioavailability, Bioequivalence and Tolerability of IHL-42X Compared to the Reference DrugsNCT05857384Bioavailability of IHL-42XPhase 1CompletedDrug: IHL42X, Acetazolamide 250 MG, Dronabinol 2.5 MGObstructive Sleep Apnea1252023-09-082024-07-31actual2025-01-17
INSPInspire Medical Systems, Inc.$1.7BInspire® Post-Approval Study / Protocol Number 2014-001NCT02413970Long-term Device-Related SAEsNot applicableUnknown statusDevice: Inspire® UAS SystemObstructive Sleep Apnea127May 2015Mar 20252024-12-27
INSPInspire Medical Systems, Inc.$1.7BThe PREDICTOR Study: Assessing Diagnostic Predictors of Airway Collapse in Patients With Obstructive Sleep ApneaNCT05428839Measurement of pharyngeal width to determine if there is correlation between pharyngeal width and presence or absence of complete concentric collapse at the soft palate during drug induced sleep endoscopyNot applicableUnknown statusDiagnostic test: Pharyngeal width measurementSleep Apnea, Obstructive3002022-05-112024-01-11actual2024-10-17
RMDResMed$31.7BRegistry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-VentilationNCT03032029observationalQuality of Life, assessed with the Functional Outcomes of Sleep Questionnaire (FOSQ) by comparing the score at baseline with the 12 months follow-up.CompletedDevice: Adaptive Servo-VentilationCentral Sleep Apnea, Complex Sleep Apnea, Obstructive Sleep Apnea, Mixed Sleep Apnea8472017-09-052022-06-30actual2024-10-16
RMDResMed$31.7BDevelopment of Advanced Leak Detection Technologies for Positive Airway Pressure Devices TherapiesNCT04741854Acoustic signalsNot applicableCompletedDevice: Positive Airway Pressure (PAP) TherapyObstructive Sleep Apnea (OSA)272020-08-262021-03-12actual2024-10-16
OGNOrganon and Co$3.6BThe Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726)NCT00359216results2009-08-03Apnea-Hypopnea IndexPhase 4CompletedDrug: Mometasone furoate nasal spray, PlaceboPerennial Allergic Rhinitis, Obstructive Sleep Apnea, Sleep Disorder30May 2006Jan 2008actual2024-05-23
RMDResMed$31.7BLong-term Benefits of CPAP or MAD Treatment on the Sleep of OSAS PatientsNCT05435794observationalTo determine the evolution of deep slow-wave sleep at one year in OSA patients according to the treatment initiated by continuous positive pressure or mandibular advancement device (MAD).RecruitingDevice: CPAP, MADOSA4002022-07-152022-10-15actual2024-05-21
AXSMAxsome Therapeutics, Inc.$11.3BSUNOSI® (Solriamfetol) Pregnancy RegistryNCT06413420observationalLong-term SafetyRecruitingDrug: Sunosi (solriamfetol), Other prescription wake-promoting medications or stimulants · Other: No treatmentNarcolepsy, Obstructive Sleep Apnea, Pregnant Women and Their Offspring1,7312019-07-31Sep 2029≤ 1,137 d2024-05-14
RMDResMed$31.7BWhitsundays (Nasal) Mask Take Home Study (90 Days)NCT0603632911 point Likert Scale QuestionnaireNot applicableCompletedDevice: Group A : provided with 1 Whitsundays Nasal mask without a spare mask cushion, Group B : provided with 1 Whitsundays Nasal mask with 2 spare mask cushionsObstructive Sleep Apnea1202023-05-312023-11-06actual2024-02-29
RMDResMed$31.7BOran Park Mask External Clinical Study (3) Marketing Claims StudyNCT0607986611 point Likert Scale QuestionnaireNot applicableCompletedDevice: Mask A (Oran Park Mask) then Mask B (Evora Mask), Mask B (Evora Mask) then Mask A (Oran Park Mask)Obstructive Sleep Apnea582023-10-042023-11-20actual2024-02-29
RMDResMed$31.7BPersonal Therapy Comfort Settings Pilot Clinical StudyNCT05376137Comparison of treatment continuance between the control group and active treatment group.Not applicableCompletedDevice: continuous positive airway pressure (CPAP)Obstructive Sleep Apnea662022-09-152023-06-30actual2023-11-18
APMDApnimedAD816 Crossover StudyNCT05793684Apnea-hypopnea index (AHI) 4%, AD816 vs. PlaceboPhase 2CompletedDrug: Period A, Period B, Period COSA, Obstructive Sleep Apnea252023-04-282023-11-09actual2023-11-15
4523.TEisai Inc.$8.7BA Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Participants With Moderate to Severe Obstructive Sleep Apnea, and in Adult and Elderly Participants With Moderate to Severe Chronic Obstructive Pulmonary DiseaseNCT04647383results2023-10-10OSA Cohort: Apnea-Hypopnea Index (AHI) on Day 8 of Treatment Periods 1 and 2Phase 1CompletedDrug: Placebo, Lemborexant 10 mg, Placebo, Lemborexant 10 mgSleep Apnea, Obstructive, Pulmonary Disease, Chronic Obstructive, Respiration Disorders632021-01-062022-02-10actual2023-10-10
APMDApnimedCrossover Trial of AD036 in Obstructive Sleep ApneaNCT04445688results2023-08-21Apnea-Hypopnea IndexPhase 2CompletedDrug: AD036, Atomoxetine, PlaceboObstructive Sleep Apnea622020-07-152020-12-01actual2023-09-14
APMDApnimedTrial of AD113 and Atomoxetine in OSA Patients With HypertensionNCT04905979Change in hypoxic burden (HB, total area under the respiratory event-related desaturation curve)Phase 2CompletedDrug: AD113, AtomoxetineObstructive Sleep Apnea, Hypertension212021-07-312023-01-31actual2023-08-21
ISRGIntuitive Surgical$138.2BTreatment of Obstructive Sleep Apnea (OSA) With the da Vinci® SP™ Surgical SystemNCT04795817observationalType 1 Polysomnography (PSG)CompletedDevice: Transoral Robotic SurgeryObstructive Sleep Apnea252021-01-272023-01-25actual2023-05-31
AXSMAxsome Therapeutics, Inc.$11.3BEvaluate Sunosi® PK in Breast Milk and Plasma of Healthy Postpartum Women Following Single Dose Oral AdministrationNCT05008341Maximum Concentration (Cmax) of Solriamfetol in Breast Milk and PlasmaPhase 1CompletedDrug: Solriamfetol 150 mg Oral TabletNarcolepsy, Obstructive Sleep Apnea, Excessive Daytime Somnolence, Excessive Sleepiness, Postpartum62021-08-272022-04-15actual2023-04-14
APMDApnimedStudy for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED)NCT05101122results2023-04-07Apnea-Hypopnea Index (AHI)4% Events Per HourPhase 1/2CompletedDrug: Dosing 1: Atomoxetine, AD313Obstructive Sleep Apnea152021-10-192022-04-18actual2023-04-07
APMDApnimedCrossover Trial of AD109 in Obstructive Sleep ApneaNCT04580394results2023-01-31Change in Hypoxic Burden (HB) Log10HB[(%*Min)/Hour]Phase 2CompletedDrug: AD109, Atomoxetine, R-oxybutynin, Placebo · Diagnostic test: Digit System Substitution TestObstructive Sleep Apnea602020-10-272021-05-28actual2023-01-31
APMDApnimedTrial of AD036 in Obstructive Sleep ApneaNCT03845023results2023-01-17Apnea Hypopnea Index (AHI)Phase 2CompletedDrug: AD036 Dose 1, AD036 Dose 2, AD036 Dose 3, PlaceboObstructive Sleep Apnea1402019-03-072019-10-23actual2023-01-17
APMDApnimedAD109 Dose Finding in Mild to Moderate OSANCT04631107results2022-12-22Change in Hypoxic Burden (HB) Log Transformed - Log10HB[(%*Min)/h]Phase 2CompletedDrug: AD109 dose1- A, AD109 dose2- B, Placebo- CObstructive Sleep Apnea322020-12-222021-05-31actual2022-12-22
APMDApnimedCrossover Trial of AD182 and AD504 in Obstructive Sleep ApneaNCT04645524Apnea-Hypopnea Index (AHI, average number of events for every hour of sleep)Phase 2CompletedDrug: AD182, AD504, Placebo · Diagnostic test: PolysomnographyObstructive Sleep Apnea152020-12-012021-09-01actual2022-09-02
INSPInspire Medical Systems, Inc.$1.7BInspire Home Study: Utilization of Home Monitoring During Therapy Optimization in Patients With an Inspire Upper Airway Stimulation System (Comparison of Home Sleep Testing vs. In-lab Polysomnography Testing)NCT04416542Comparison of Apnea-Hypopnea Index (AHI), between the two randomization armsNot applicableCompletedDiagnostic test: Home Sleep TestingObstructive Sleep Apnea642020-07-282022-06-10actual2022-06-21
RMDResMed$31.7BValidation of ApneaLink Air Home Sleep Testing in the Diagnosis of Obstructive Sleep Apnea in Adolescent ChildrenNCT03748771results2021-11-15Accuracy of HST Compared to ALT (ApneaLink Lab Testing) and PSG (Polysomnography)CompletedDevice: ApneaLink AirSleep Apnea, Obstructive202018-12-012020-02-28actual2021-11-15
NYXH.BRNyxoah S.A.$46MBiLAteral Hypoglossal Nerve Stimulation for Treatment of Obstructive Sleep Apnoea (BLAST OSA)NCT03048604Safety (Incidence of serious device-related adverse events)Not applicableCompletedDevice: Genio(TM) bilateral hypoglossal nerve stimulation systemObstructive Sleep Apnea of Adult272017-03-302018-09-10actual2021-10-11
RMDResMed$31.7BEvaluating the Efficacy of PAP Therapy for Treating OSA in the Home EnvironmentNCT04744038UsabilityNot applicableCompletedDevice: Positive Airway Pressure (PAP) TherapyObstructive Sleep Apnea (OSA)1082020-08-122021-03-05actual2021-07-13
RMDResMed$31.7BEvaluation of an Incentive-based Intervention to Improve 90-day Adherence in PAP-Naive PatientsNCT03851094results2021-06-15Mean PAP Usage at 90 DaysNot applicableCompletedBehavioral: Wellth appObstructive Sleep Apnea1662019-03-112020-05-18actual2021-06-15
RMDResMed$31.7BEvaluation of a Health Dashboard Intervention to Improve Engagement With CPAP Therapy in PAP-Naïve Patients: Project NeoNCT04912635Mean CPAP use hoursNot applicableCompletedOther: Neo AppSleep Apnea, Obstructive3002020-09-252020-12-19actual2021-06-03
RMDResMed$31.7BFoam Mask - Assessment of Bioburden in a New Mask Seal MaterialNCT00773721Measurement of bacterial accumulation in the new material.Not applicableCompletedDevice: CPAP maskObstructive Sleep Apnea (OSA)20Oct 2008Dec 2008actual2021-02-04
RMDResMed$31.7BImproved Automatic CPAP Algorithm to Treat Obstructive Sleep Apnea (OSA)NCT00850434Physiological sleep signals including EEG, Sp02, respiratory effort and nasal flow, will be recorded, analysed and reported in the form of a series of indices, which are the outcome variables of the study.Not applicableCompletedDevice: Modified AutoSet Algorithm, Standard AutoSet AlgorithmObstructive Sleep Apnea (OSA)20Nov 2005Sep 2008actual2021-02-04
RMDResMed$31.7BPerformance of the Tasman Continuous Positive Airway Pressure (CPAP) SystemNCT01171066To determine if the efficacy of the treatment is clinically equivalent to or better than the predicate device (S8 Escape)Not applicableCompletedDevice: Tasman CPAP systemObstructive Sleep Apnea57Jun 2010Oct 2012actual2021-02-04
RMDResMed$31.7BAnalysis of a New Mask for Positive Airway Pressure (PAP) Device UsersNCT01847846To measure and compare the prevalence of microorganisms within the new mask over a period of 8 weeksNot applicableCompletedDevice: CPAP mask - prototypeObstructive Sleep Apnea23Jul 2014Oct 2014actual2021-02-04
RMDResMed$31.7BUsability Evaluation of Menai CPAP MasksNCT02364375Usability Performance EvaluationNot applicableCompletedDevice: Menai mask (full face), Menai Standard mask (full face), Menai mask (nasal), Menai Standard mask (nasal), Menai mask (pillows), Menai Standard mask (pillows)Obstructive Sleep Apnea30May 2015Jul 2015actual2021-02-04
RMDResMed$31.7BComparison of Two Continuous Positive Airway Pressure SystemsNCT02535234Subjective usability ratings of the prototype system using a visual analogue scale, compared to a reference level and the second full system.Not applicableCompletedDevice: Novel System, Traditional SystemObstructive Sleep Apnoea30Apr 2016Jun 2016actual2021-02-04
RMDResMed$31.7BVent Flow Study of Prototype Nasal CPAP MaskNCT02805777Changes in vent flow of the mask system, which will be recorded on a flow testing rig (units= LPM). Baseline flow in LPM will be compared to that at the conclusion of the trial.Not applicableWithdrawnsponsor's stated reason: Study not required due to change in deviceDevice: CPAP maskObstructive Sleep Apnea (OSA)02017-05-01Dec 20172021-02-04
RMDResMed$31.7BNebula Study - Screener Apps and HSAT vs. PSG ComparisonNCT04597749AHI value. Clinical decision for treatment output (Y to CPAP or N to CPAP) of Screener apps and HSAT compared to PSG.Not applicableCompletedDiagnostic test: PSG, Home Sleep Apnea Test with FDA cleared devices · Other: Non-Contact Screening AppSleep Apnea, Obstructive502020-10-272020-12-31actual2021-02-04
RMDResMed$31.7BBioburden and Usability Evaluation of a Nasal Prototype CPAP MaskNCT02255539Changes from baseline in Bioburden and Impedance of the prototype mask components at 6 weeksNot applicableCompletedDevice: Geelong Prototype MaskObstructive Sleep Apnea42Jan 2015Mar 2015actual2021-02-01
RMDResMed$31.7BAssessment of the Effect of PAP on Energy and Vitality in Mild OSA Patients: The Merge StudyNCT02699463results2021-01-26Change in Quality of Life Using the Energy and Vitality Subscale of the Short Form 36 (SF-36) QuestionnaireNot applicableCompletedDevice: Continous Positive Airway Pressure · Other: Control GroupObstructive Sleep Apnea301Dec 2016May 2019actual2021-01-26
JAZZJazz Pharmaceuticals$16.4BStudy Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in OSANCT02806895results2020-06-16Standard Deviation of Lateral Position (SDLP) at 2 Hours Post-dose (Approximately at Tmax)Phase 2CompletedDrug: JZP-110, PlaceboObstructive Sleep Apnea, Excessive Sleepiness342016-07-052019-05-28actual2021-01-14
RMDResMed$31.7BAn Exploratory Investigation of the Use of Drive App to Measure Sleep Parameters in Users of CPAP TherapyNCT04500327Identify any failures when using the Drive app for users of CPAP therapyNot applicableUnknown statusOther: Drive app · Device: Non contact motion sensorObstructive Sleep Apnea122020-06-25Jun 20212020-08-05
INSPInspire Medical Systems, Inc.$1.7BInspire® Upper Airway Stimulation (UAS) System German Post-Market StudyNCT02293746Number of Reported SAEs / Procedure & Device Related AEsPhase 4CompletedDevice: Inspire® Upper Airway Stimulation (UAS) SystemObstructive Sleep Apnea60Jun 20142016-12-11actual2020-07-02
RMDResMed$31.7BEvaluation of ApneaLink Plus Scoring CapabilitiesNCT00823134results2020-05-12Assessment of the Apnoea-Hypopnea-Index (Number of Apneas (All Apneas, Obstructive, Mixed, Central) and Number of Hypopneas) Between ApneaLink Plus and a PSG System Within the Same Evaluation PeriodNot applicableCompletedDevice: ApneaLink PlusSleep Apnea, Central, Sleep Apnea, Obstructive23Dec 2008Mar 2009actual2020-05-12
RMDResMed$31.7BComparison of Auto-Adjusting Positive Airway Pressure DevicesNCT02357706results2020-04-20Mean Apnoea-Hypopnoea-Index (AHI)Not applicableCompletedDevice: APAP A (ResMed AirSense AutoSet), APAP B (Apex iCH Auto)Obstructive Sleep Apnea20Jan 2015Jun 2015actual2020-04-20
RMDResMed$31.7BNarval CC Mandibular Repositioning Device in the Second-line Treatment of Severe Obstructive Sleep Apnea Hypopnea (OSAH)NCT01326143observationalPercentage of patients with Apnea/Hypopnea Index (AHI) reduced by at least 50% compared to baseline measured by Polygraphy/Polysomnography (PG/PSG)CompletedDevice: ORM Narval MRDObstructive Sleep Apnea Syndrome360May 2011Feb 2019actual2020-04-02
RMDResMed$31.7BProspective Cohort Study of Patients Intolerant to High Pressure Under Continuous Positive Airway Pressure Treated With Bilevel Positive Airway Pressure as Second-line Therapy.NCT02930460observationalComplianceTerminatedObstructive Sleep Apnea30Nov 2016Nov 2018actual2020-02-28
4523.TEisai Inc.$8.7BStudy to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep ApneaNCT03471871results2020-01-18HV Cohort: Peripheral Oxygen Saturation (SpO2) During Total Sleep Time (TST) on Day 1 of TreatmentPhase 1CompletedDrug: Placebo, Lemborexant 10 mg, Lemborexant 25 mg, Placebo, Lemborexant 10 mgObstructive Sleep Apnea, Healthy Subjects1462018-02-212018-08-03actual2020-02-17
RMDResMed$31.7BAutoSet for Her Quality of Life Clinical TrialNCT02400073results2019-10-02Assessment of Quality of Life Using the Functional Outcomes of Sleep Questionnaire (FOSQ)Not applicableCompletedDevice: AutoSet for HerObstructive Sleep Apnea1222015-03-192017-01-05actual2019-10-02
JAZZJazz Pharmaceuticals$16.4B"Six-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"NCT02348619results2019-09-09Change in the Maintenance of Wakefulness Test (MWT)Phase 3CompletedDrug: JZP-110Obstructive Sleep Apnea174May 2015Nov 2016actual2019-09-09
JAZZJazz Pharmaceuticals$16.4B"Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"NCT02348606results2019-07-23Change in Maintenance of Wakefulness Test (MWT) From Baseline to Week 12Phase 3CompletedDrug: JZP-110, Placebo oral tabletObstructive Sleep Apnea476May 2015Dec 2016actual2019-07-23
JAZZJazz Pharmaceuticals$16.4B"A Long-Term Safety Study of JZP-110 in the Treatment of Excessive Sleepiness in Subjects With Narcolepsy or OSA"NCT02348632results2019-06-25Change in Epworth Sleepiness Scale (ESS) ScorePhase 3CompletedDrug: JZP-110Narcolepsy, Obstructive Sleep Apnea645May 2015Dec 2017actual2019-06-25
NVONovo Nordisk A/SEffect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep ApnoeaNCT01557166results2015-02-09Change From Baseline in Apnoea-hypopnoea Index (AHI)Phase 3CompletedDrug: liraglutide, placeboMetabolism and Nutrition Disorder, Obesity, Obstructive Sleep Apnoea3592012-06-072013-06-01actual2017-11-01
LIVNLivaNova$4.4BPErsonalized and Adaptive Kinesthetic stImulation Therapy, Based on Cardio-respiratory Holter moNitoring, for Sleep Apnea syndrOmesNCT02789748Rate of responder to the therapyNot applicableCompletedDevice: Kinesthetic stimulationObstructive Sleep Apnea Syndrome422016-06-012017-10-02actual2017-10-05
LIVNLivaNova$4.4BHYpopnea and Apnea Detection and Treatment Performance of a New cardiOreSpiratory Holter MonitorNCT03300037observationalPerformance of real-time detector of apnea and hypopnea: sensitivity and positive predictive value of the detector will be calculated when comparing automatically detected respiratory events to gold-standard PSG scoring of apnea/hypopnea events.CompletedDevice: Kinesthetic stimulationSleep Apnea, Obstructive462014-09-012015-04-16actual2017-10-03
RMDResMed$31.7BClinical Impact of 2 Types of Mandibular Retention Devices - Narval O.R.M CadCam Design vs Narval O.R.M Traditional Design - on Obstructive Sleep Apnea (OSA) Therapy: ESTAMPS StudyNCT02755662upper airway volumeNot applicableCompletedDevice: Mandibular Retention DeviceObstructive Sleep Apnea Syndrome12May 2016Jul 2017actual2017-09-28
INSPInspire Medical Systems, Inc.$1.7BStimulation Therapy for Apnea Reduction (Www.theSTARtrial.Com)NCT01161420results2014-12-15Apnea Hypopnea IndexPhase 3CompletedDevice: Inspire Upper Airway Stimulation SystemObstructive Sleep Apnea929Jul 2010Mar 2013actual2017-08-25
RMDResMed$31.7BValidation of the ApneaLink Sleep Screener for Obstructive Sleep Apnea (OSA)NCT00354614results2017-06-28observationalSensitivity and SpecificityCompletedDevice: ApneaLink Sleep ScreenerObstructive Sleep Apnea81Jun 2006Mar 2007actual2017-06-28
RMDResMed$31.7BStudy of the Usability and Efficacy of a New Pediatric CPAP MaskNCT01312948results2012-03-19Usability Ratings of the Pixi Paediatric Mask Compared With the Child's Current MaskNot applicableCompletedDevice: Prototype mask (known as Pixi)Obstructive Sleep Apnea, Respiratory Insufficiency6Jan 2011Jun 2011actual2017-06-26

Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.

How Obstructive Sleep Apnea is matched — 8 exact registry spellings

A study is on this page when its ClinicalTrials.gov record names one of these conditions exactly (letter case aside). Nothing is matched by substring or stem, so a longer condition that merely contains one of these words is a different page. The list was curated by hand and last measured 2026-08-19; a spelling filed by only one study was not curated, so the counts here are a floor rather than the registry's own total for the disease.

  • Obstructive Sleep Apnea
  • Obstructive Sleep Apnea (OSA)
  • OSA
  • Sleep Apnea, Obstructive
  • Obstructive Sleep Apnea Syndrome
  • Obstructive Sleep Apnoea
  • OSA - Obstructive Sleep Apnea
  • Obstructive Sleep Apnea of Adult

Permalink · All conditions · Catalyst calendar · Every registered study · Search the whole pipeline for “Obstructive Sleep Apnea” (a text search, wider than this page)