Avascular Necrosis trial readouts
registry pull 2026-08-19Primary-completion dates that listed drug and biotech companies filed with ClinicalTrials.gov for studies in Avascular Necrosis. They are the sponsor's own estimated windows, revised as a study runs — not announcement dates. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Upcoming readout windows
next 180 days · by month3 studies across 1 company, in the next 180 days.
December 2026 2
| Ticker | Name | Study | Phase | Status | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|
| ZBH | Zimmer Biomet | Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder SystemNCT01480440observationalSurvivorship | — | Active, not recruiting | Dec 2026 | ≤ 133 d | 2026-04-28 |
| ZBH | Zimmer Biomet | Database Retrieval for the Comprehensive ShoulderNCT03409718observationalImplant survivorship is assessed counting the number of implant revisions | — | Active, not recruiting | Dec 2026 | ≤ 133 d | 2026-07-10 |
January 2027 1
| Ticker | Name | Study | Phase | Status | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|
| ZBH | Zimmer Biomet | PMCF Study on the Safety and Performance of the Zimmer® Maxera™ Acetabular System in Total Hip ArthroplastyNCT03372278observationalImplant survival based on removal or intended removal of the device and determined using the Kaplan-Meier method | — | Active, not recruiting | Jan 2027 | ≤ 164 d | 2025-06-15 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Every registered study in Avascular Necrosis
most recently updated first69 studies match.
| Ticker | Name | Market cap | Study | Phase | Status | Interventions | Conditions | Enrollment | Start | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZBH | Zimmer Biomet | $18.9B | Persona Ti-Nidium Post-Market Clinical Follow-upNCT04817969Oxford Knee Score (OKS) | Not applicable | Active, not recruiting | Device: Zimmer Biomet Persona Ti-Nidium Total Knee System | Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of the Knee, Avascular Necrosis, Patellofemoral Osteoarthritis | 240 | 2021-06-01 | May 2034 | ≤ 2,841 d | 2026-08-17 |
| ZBH | Zimmer Biomet | $18.9B | Persona SoluTion PPS Femur PMCFNCT07286513observationalChange in KOOS JR Score between pre-op and 2 years post-op | — | Enrolling by invitation | Device: Total knee arthroplasty | Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis, Collagen Disorders, Avascular Necrosis of Femoral Condyle, Valgus Deformity, Varus Deformity, Flexion Deformity of Knee | 200 | 2026-02-26 | Dec 2029 | ≤ 1,229 d | 2026-08-17 |
| ZBH | Zimmer Biomet | $18.9B | G7 Acetabular System With Vivacit-E or Longevity Liner PMCF StudyNCT04754087Survival of the study device (liner); whether or not it is still implanted in the subject | Not applicable | Active, not recruiting | Device: Vivacit-E and Longevity (HXLPE) Liners | Total Hip Arthroplasty, Degenerative Joint Disease of Hip, Avascular Necrosis of Hip, Rheumatoid Arthritis of Hip, Osteoarthritis, Hip, Osteoarthritis of Hip, Fractures, Hip, Fracture of Hip | 300 | 2021-07-07 | 2033-12-31 | in 2,690 d | 2026-07-16 |
| ZBH | Zimmer Biomet | $18.9B | Database Retrieval for the Comprehensive ShoulderNCT03409718observationalImplant survivorship is assessed counting the number of implant revisions | — | Active, not recruiting | Device: Biomet Comprehensive Shoulder System | Osteoarthritis of the Shoulder, Avascular Necrosis, Rheumatoid Arthritis, Prior Failed Revision, Correction of Functional Deformity, Fracture of Proximal End of Humerus, Cuff Tear Arthropathy | 160 | 2011-02-24 | Dec 2026 | ≤ 133 d | 2026-07-10 |
| ZBH | Zimmer Biomet | $18.9B | Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)NCT05787821observationalOxford Knee Score (OKS) | — | Active, not recruiting | Device: Total Knee Arthroplasty | Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee, Avascular Necrosis | 760 | 2023-06-28 | 2026-06-30actual | — | 2026-07-10 |
| ZBH | Zimmer Biomet | $18.9B | TESS V3 Modular Total Shoulder System PMCFNCT05002959observationalImplant survival at 10 years | — | Terminatedsponsor's stated reason: Termination of PMCF study due to product discontinuation (commercial reasons) | Device: Anatomic TESS V3, Reverse TESS V3 | Osteoarthritis Shoulder, Rheumatoid Arthritis, Rheumatoid Arthritis Shoulder, Avascular Necrosis, Revision, Rotator Cuff Tears, Osteonecrosis, Rotator Cuff Tear Arthropathy, Proximal Humeral Fracture, Malunion of Fracture, Shoulder Region | 67 | 2022-02-01 | 2026-03-05actual | — | 2026-06-09 |
| ZBH | Zimmer Biomet | $18.9B | Sidus(TM) Post Market Clinical Follow-up (PMCF) StudyNCT01700543observationalFunctional Performance (Constant & Murley Score) | — | Completed | Procedure: Shoulder Arthroplasty | Non-inflammatory Degenerative Joint Disease (NIDJD), Avascular Necrosis, Osteoarthritis, Inflammatory Joint Disease (IJD), Rheumatoid Arthritis | 152 | Oct 2012 | Jul 2020actual | — | 2026-06-08 |
| ZBH | Zimmer Biomet | $18.9B | ROSA Total Knee Post Market Study EMEANCT04338893results2026-01-21Alignment Accuracy | Not applicable | Completed | Procedure: Device: Persona Total Knee, Device: NexGen Total Knee, Device: Vanguard Total Knee | Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis | 252 | 2020-12-15 | 2025-08-22actual | — | 2026-05-12 |
| ZBH | Zimmer Biomet | $18.9B | Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder SystemNCT01480440observationalSurvivorship | — | Active, not recruiting | Device: Trabecular Metal Reverse Shoulder System | Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Ununited Humeral Head Fracture, Irreducible 3-and 4-part Proximal Humeral Fractures, Avascular Necrosis, Gross Rotator Cuff Deficiency, Revision Total Shoulder Arthroplasty | 200 | Jan 2011 | Dec 2026 | ≤ 133 d | 2026-04-28 |
| ZBH | Zimmer Biomet | $18.9B | Cemented vs Cementless Persona Keel RCTNCT05630053Oxford Knee Score (OKS) | Not applicable | Active, not recruiting | Device: Cementless Persona Knee System, Cemented Persona Knee System | Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis, Polyarthritis, Avascular Necrosis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee | 300 | 2023-07-25 | May 2032 | ≤ 2,111 d | 2026-04-27 |
| ZBH | Zimmer Biomet | $18.9B | Persona Partial Knee Clinical Outcomes StudyNCT03034811Oxford Knee Score | Not applicable | Active, not recruiting | Device: Persona Partial Knee system | Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Conditional Tibial Condyle or Plateau Fractures, Conditional Revision of the Articular Surface | 757 | 2017-02-08 | Sep 2030 | ≤ 1,502 d | 2026-04-22 |
| ZBH | Zimmer Biomet | $18.9B | Comprehensive Nano - Post Market Clinical Follow-Up StudyNCT03423953observationalSurvivorship | — | Active, not recruiting | Device: Comprehensive Nano | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Revision, Correction of Functional Deformity | 194 | 2013-10-30 | 2030-07-31 | in 1,441 d | 2026-04-21 |
| ZBH | Zimmer Biomet | $18.9B | SCP Hip Outcomes StudyNCT03494660results2026-04-21observationalOverall Group Mean Improvement From Baseline of the Modified Harris Hip Score (mHHS) at 2 Years | — | Completed | Device: Subchondroplasty Procedure with AccuFill | Subchondral Cysts, Subchondral Bone Edema, Bone Marrow Edema, Insufficiency Fractures, Avascular Necrosis of Hip, Femoroacetabular Impingement, Dysplasia; Hip | 77 | 2018-03-27 | 2023-10-23actual | — | 2026-04-21 |
| ZBH | Zimmer Biomet | $18.9B | MDR Vivacit-E Elevated StudyNCT07150221observationalSurvival of the Implant System via Adverse Events | — | Enrolling by invitation | Device: Vivacit-E Elevated Liners | Osteoarthritis (OA) of the Hip, Avascular Necrosis of Bone of Hip, Protrusio Acetabuli, Traumatic Arthropathy-Hip, Slipped Capital Femoral Epiphyses, Fused Hip, Fracture of Pelvis, Diastrophic Variant | 52 | 2026-01-07 | Dec 2027 | ≤ 498 d | 2026-04-01 |
| ZBH | Zimmer Biomet | $18.9B | Anatomical Shoulder Domelock System StudyNCT03312465observationalImplant Survivorship | — | Active, not recruiting | Device: AS Domelock System | Avascular Necrosis, Revision Surgery, Conditions Consequent to Earlier Operations, Arthritis, Rheumatoid, Arthritis, Degenerative, Arthritis;Traumatic | 73 | 2017-09-28 | 2032-12-09 | in 2,303 d | 2026-03-25 |
| SNN | Smith & Nephew, Inc. | — | A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip SystemNCT06564636observationalCollared CATALYSTEM™ femoral stem implant survivorship 2 years post-operatively | — | Active, not recruiting | Device: CATALYSTEM | Total Hip Arthroplasty (THA), Osteoarthritis, Degenerative Joint Disease, Inflammatory Arthritis, Avascular Necrosis, Post-traumatic Arthritis, Congenital Hip Dysplasia | 119 | 2024-09-26 | Dec 2027 | ≤ 498 d | 2026-03-12 |
| ZBH | Zimmer Biomet | $18.9B | Persona Total Knee Arthroplasty Outcomes StudyNCT02255383Knee Society Score | Not applicable | Active, not recruiting | Device: Zimmer Persona Total Knee System | Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Moderate Varus, Valgus or Flexion Deformities, Avascular Necrosis of the Femoral Condyle | 737 | Jul 2014 | Dec 2025actual | — | 2026-03-10 |
| ZBH | Zimmer Biomet | $18.9B | Allofit® IT With HXPE in Total Hip ArthroplastyNCT03672929results2026-01-27observationalSurvival of the Implant System | — | Completed | — | Avascular Necrosis, Osteoarthritis, Hip, Inflammatory Arthritis, Post-Traumatic Osteoarthritis of Hip | 197 | 2011-06-05 | 2025-07-03actual | — | 2026-01-27 |
| ZBH | Zimmer Biomet | $18.9B | BC Study of G7 Cup and Compatible Femoral StemsNCT03456622observationalSurvival of the implant system | — | Active, not recruiting | — | Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis | 230 | Nov 2015 | Jun 2029 | ≤ 1,045 d | 2025-11-25 |
| ZBH | Zimmer Biomet | $18.9B | Z1 Hip System: Post-Market Clinical Follow Up StudyNCT07104279observational2 Year Survivorship | — | Recruiting | Device: Z1 Femoral Hip System | Hip Osteoarthritis, Acute Traumatic Fracture of the Femoral Head or Neck, Avascular Necrosis of the Femoral Head | 150 | 2025-10-13 | Aug 2028 | ≤ 742 d | 2025-11-10 |
| ZBH | Zimmer Biomet | $18.9B | G7 Freedom Constrained Vivacit-E LinersNCT05587244Survival of the study device | Not applicable | Enrolling by invitation | Device: Total Hip Arthroplasty with G7 Freedom Constrained Vivacit-E Liners | Osteoarthritis, Hip, Rheumatoid Arthritis, Non-Union Fracture, Trochanteric Fractures, Femoral Neck Fractures, Avascular Necrosis, Dislocation, Hip | 202 | 2023-05-08 | Dec 2037 | ≤ 4,151 d | 2025-10-20 |
| ZBH | Zimmer Biomet | $18.9B | G7 BiSpherical Acetabular Shell PMCF StudyNCT03266874observationalImplant survivorship is assessed counting the number of implant revisions | — | Active, not recruiting | — | Rheumatoid Arthritis, Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Correction of Functional Deformity, Non-Union Fracture, Femoral Neck Fractures, Trochanteric Fractures | 160 | 2017-12-10 | Dec 2029 | ≤ 1,229 d | 2025-06-25 |
| ZBH | Zimmer Biomet | $18.9B | Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) StudyNCT01307384observationalSurvivorship | — | Active, not recruiting | Device: Continuum Metal on Polyethylene Acetabular System | Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis | 165 | 2011-03-29 | Dec 2027 | ≤ 498 d | 2025-06-18 |
| ZBH | Zimmer Biomet | $18.9B | Exception Cementless Hip StemNCT04349046observationalImplant survival based on removal or intended removal of the device and determined using the Kaplan-Meier method | — | Active, not recruiting | Device: Total hip arthoplasty (THA) | Osteoarthritis, Hip, Rheumatoid Arthritis, Inflammatory Arthritis, Congenital Hip Dysplasia, Avascular Necrosis of Hip, Femoral Neck Fractures | 332 | 2021-01-01 | 2024-05-01actual | — | 2025-06-18 |
| ZBH | Zimmer Biomet | $18.9B | Avenir Complete Post-Market Clinical Follow-Up StudyNCT04731077Survival of the study device; whether or not it is still implanted in the subject | Not applicable | Active, not recruiting | Device: Avenir Complete Femoral Stem | Osteoarthritis, Hip, Avascular Necrosis of Hip, Avascular Necrosis of the Femoral Head, Post-traumatic; Arthrosis | 275 | 2021-09-27 | 2035-06-01 | in 3,207 d | 2025-06-18 |
| ZBH | Zimmer Biomet | $18.9B | PMCF Study on the Safety and Performance of the Zimmer® Maxera™ Acetabular System in Total Hip ArthroplastyNCT03372278observationalImplant survival based on removal or intended removal of the device and determined using the Kaplan-Meier method | — | Active, not recruiting | — | Rheumatoid Arthritis With Adequate Bone Quality, Inflammatory Arthritis, Osteoarthritis, Hip, Avascular Necrosis, Post-traumatic; Arthrosis, Congenital Hip Dysplasia | 250 | Jan 2013 | Jan 2027 | ≤ 164 d | 2025-06-15 |
| ZBH | Zimmer Biomet | $18.9B | G7 Dual Mobility With Vivacit-E or Longevity PMCFNCT05548972Survival of the implant system | Not applicable | Enrolling by invitation | Device: G7 Dual Mobility with Vivacit-E bearing, G7 Dual Mobility Longevity bearing | Hip Osteoarthritis, Rheumatoid Arthritis, Joint Diseases, Avascular Necrosis, Dislocation, Hip, Femoral Neck Fractures, Trochanteric Fractures, Revision Surgeries | 358 | 2023-03-20 | Jan 2037 | ≤ 3,817 d | 2025-06-15 |
| ZBH | Zimmer Biomet | $18.9B | Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient PopulationNCT02087449observationalHHS score | — | Terminatedsponsor's stated reason: Sponsor decided to terminate study. | Device: E1-Hip Bearing | Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Rheumatoid Arthritis, Legg-perthes Disease | 100 | Feb 2013 | Dec 2017actual | — | 2025-04-02 |
| SNN | Smith & Nephew, Inc. | — | Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Unicondylar Knee Arthroplasty (UKA) ProceduresNCT04797897results2025-03-25Post-operative Leg Alignment | Not applicable | Terminatedsponsor's stated reason: The Study terminated prematurely due to very low patient enrollment in the study. | Device: CORI, Conventional | Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Requires Correction of Functional Deformity, Fracture, Knee | 4 | 2022-02-12 | 2023-09-29actual | — | 2025-03-25 |
| ZBH | Zimmer Biomet | $18.9B | Allofit® IT Ceramic Bearing System in Total Hip ArthroplastyNCT03672916results2025-02-12observationalSurvivorship | — | Completed | — | Avascular Necrosis of Hip, Osteoarthritis, Hip, Inflammatory Arthritis, Post-Traumatic Osteoarthritis of Hip | 185 | May 2011 | Apr 2023actual | — | 2025-02-12 |
| ZBH | Zimmer Biomet | $18.9B | ROSA® Hip System THA PMCFNCT05497206Accuracy of implant position | Not applicable | Terminatedsponsor's stated reason: The data needed for regulatory submissions based on the current pace of the study, will not be available in the foreseeable future. | Device: One of the following hip implants may be used within this arm of the study: G7 Acetabular System, Taperloc Complete System, Avenir and Avenir Complete Systems, and Echo Bi-Metric System | Osteoarthritis, Hip, Avascular Necrosis of Hip | 12 | 2024-06-05 | 2024-12-12actual | — | 2025-02-05 |
| ZBH | Zimmer Biomet | $18.9B | Continuum Ceramic on Ceramic Bearing Post Market Clinical Follow-Up StudyNCT03343171observationalSafety will be evaluated by adverse events reporting. | — | Active, not recruiting | — | Osteoarthritis, Avascular Necrosis, Inflammatory Arthritis, Post-traumatic Arthritis | 203 | 2010-09-15 | Feb 2025 | — | 2025-01-31 |
| ZBH | Zimmer Biomet | $18.9B | Arcos Revision Stem: Evaluation of Clinical PerformanceNCT01820611results2025-01-20observationalSurvivorship | — | Completed | Device: Arcos Revision Stem System | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Deformity, Fracture, Complications; Arthroplasty | 74 | Feb 2013 | 2021-06-14actual | — | 2025-01-20 |
| ZBH | Zimmer Biomet | $18.9B | Continuum™ Metal Bearing System in Total Hip ArthroplastyNCT03382652results2024-12-16observationalImplant Survival at 10 Years | — | Completed | Device: Metal-on-Metal Articulation | Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Post-traumatic; Arthrosis, Total Hip Arthroplasty | 83 | 2011-02-09 | 2022-10-22actual | — | 2025-01-03 |
| ZBH | Zimmer Biomet | $18.9B | Vivacit-E Post-market Follow-up StudyNCT03226808Survival of the study device; whether or not it is still implanted in the subject | Not applicable | Active, not recruiting | Device: Vivacit-E Liner | Osteoarthritis, Avascular Necrosis of Bone of Hip, Post-traumatic; Arthrosis, Congenital Hip Dysplasia | 258 | 2013-10-01 | 2026-03-02 | — | 2025-01-01 |
| ZBH | Zimmer Biomet | $18.9B | NexGen TM Tibia Clinical Outcomes StudyNCT03272373results2024-12-05Radiograph Assessment of Progressive Tibial Radiolucencies | Not applicable | Completed | Device: NexGen TM Monoblock Tibia, NexGen TM Modular Tibia | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Collagen Disorders and/or Avascular Necrosis of the Femoral Condyle, Post-traumatic Loss of Joint Configuration, Moderate Valgus, Varus, or Flexion Deformities | 160 | 2017-10-03 | 2023-03-30actual | — | 2024-12-30 |
| ZBH | Zimmer Biomet | $18.9B | MDR - Longevity IT Oblique and Offset LinersNCT05980234observationalIncidence of treatment-emergent Adverse Events (safety) | — | Terminatedsponsor's stated reason: Zimmer Biomet received the CE mark for the Continuum and Trilogy IT Acetabular System, which includes the Longevity IT Offset and Oblique Liners, in June 2024. | Device: Total Hip Arthroplasty with Longevity IT Oblique Liners, Total Hip Arthroplasty with Longevity IT Offset Liners | Non-inflammatory Degenerative Joint Disease (NIDJD), Avascular Necrosis, Protrusio Acetabuli, Traumatic Arthritis, Slipped Capital Femoral Epiphyses, Fracture of the Pelvis, Diastrophic Variant, Osteoarthritis, Fused Hip | 6 | 2023-08-30 | 2024-11-02actual | — | 2024-12-27 |
| ZBH | Zimmer Biomet | $18.9B | Metasul Monoblock Component™ Cup in a Hip Resurfacing Application With the Durom® Hip Resurfacing Femoral ComponentNCT03681639results2024-12-03Implant Survival | Not applicable | Completed | Diagnostic test: Serum Metal ion levels determined to monitor changes in chromium and cobalt levels | Avascular Necrosis of Hip, Osteoarthritis, Hip, Rheumatoid Arthritis, Inflammatory Arthritis, Post-traumatic; Arthrosis | 45 | 2009-08-01 | 2023-05-22actual | — | 2024-12-03 |
| ZBH | Zimmer Biomet | $18.9B | Fitmore Hip Stem PMCF Study: A Multi-centre, Non-comparative, Prospective Post-market Clinical Follow-up Study.NCT03411044results2024-10-17observationalHarris Hip Score | — | Completed | Device: Fitmore Hip Stem | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Prosthesis Failure | 420 | 2008-02-08 | 2023-06-10actual | — | 2024-11-05 |
| ZBH | Zimmer Biomet | $18.9B | Persona TM Tibia Clinical Outcomes StudyNCT03589300results2024-07-23Radiograph Assessment of Progressive Tibial Radiolucencies | Not applicable | Completed | Device: Persona TM Tibia | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Collagen Disorders and/or Avascular Necrosis of the Femoral Condyle, Post-traumatic Loss of Joint Configuration, Moderate Valgus, Varus, or Flexion Deformities | 148 | 2018-04-30 | 2022-11-30actual | — | 2024-07-23 |
| ZBH | Zimmer Biomet | $18.9B | ROSA Robot Used in Total Knee Replacement Post Market StudyNCT03969654results2024-05-03Clinical Performance | Not applicable | Completed | Device: PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee | Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis | 181 | 2020-05-01 | 2023-09-22actual | — | 2024-05-03 |
| SNN | Smith & Nephew, Inc. | — | Clinical Evaluation of the TITAN™ Total Shoulder SystemNCT03245320observationalImplant survival at 2 years | — | Terminatedsponsor's stated reason: Terminated by the Sponsor. Decision not due to adverse events, complications, or device issues. | Device: Integra TITAN™ Total Shoulder Generation 1.0 | Arthritis, Arthritis, Degenerative, Rheumatoid Arthritis, Post-traumatic Arthrosis of Other Joints, Shoulder Region, Rotator Cuff Syndrome of Shoulder and Allied Disorders, Fracture, Avascular Necrosis, Joint Instability, Joint Trauma, Dislocation, Shoulder, Pain, Shoulder | 50 | 2017-03-20 | 2022-03-22actual | — | 2023-12-21 |
| ZBH | Zimmer Biomet | $18.9B | Post-market Surveillance Study With the HYPERION Hip Endoprosthesis System in Defect ReconstructionNCT03382665results2020-08-21observationalPain and Walking Ability Determined by a Merle d' Aubigné Score Increase of >4 Points. | — | Terminatedsponsor's stated reason: CE mark will not be renewed, PMCF data no longer required | — | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Functional Deformities, Pseudoarthrosis, Revision of Endoprosthesis-treated Hips, Fracture, Proximal Humeral, Provision of Non-endoprosthetic Previous Operations of the Hip Joint (e.g., Transposition Osteotomies), Femur Fracture, Pseudarthrosis, Trochanteric Fractures, Bridging of Large Bone Defects, Revisions | 70 | Jan 2010 | Aug 2017actual | — | 2023-04-07 |
| ZBH | Zimmer Biomet | $18.9B | Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing KneeNCT00854295results2023-02-14Group 2 - Total Knee Society Score (KSS) | Not applicable | Completed | Device: NexGen LPS-Flex Mobile Bearing Knee | Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus, Flexion Deformities | 266 | Apr 2009 | Jun 2020actual | — | 2023-02-14 |
| ZBH | Zimmer Biomet | $18.9B | Signature Acetabular Posterior/Lateral Data CollectionNCT02220478results2022-10-25Operative Room Time | Not applicable | Terminatedsponsor's stated reason: Unable to engage surgeons to participate in the study | Device: Posterior Lateral Approach Total Hip Arthroplasty | Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Rheumatoid Arthritis | 24 | Nov 2014 | Jul 2016actual | — | 2022-10-25 |
| ZBH | Zimmer Biomet | $18.9B | Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty.NCT03409666results2022-07-14Stability Over a Period of Two Year Measured by Migration With Röntgen Stereophotogrammetric Analysis (RSA) | Not applicable | Completed | Device: Taperloc Complete Microplasty stem, Taperloc Complete Reduced Distal stem | Hip Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Correction of Functional Deformity, Rheumatoid Arthritis | 50 | 2017-05-12 | 2020-11-06actual | — | 2022-07-14 |
| ZBH | Zimmer Biomet | $18.9B | ROSA Total Knee Investigational Testing Authorization StudyNCT03970629EQ-5D questionnaire | Not applicable | Terminatedsponsor's stated reason: Challenging enrollment due to COVID-19. | Device: PERSONA Total Knee | Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis | 19 | 2019-06-20 | 2021-11-23actual | — | 2022-05-19 |
| ZBH | Zimmer Biomet | $18.9B | Biologically Assisted Core Decompression of the Femoral Head Using the PerFuse Instrument and BioCUENCT02662881observationalHarris Hip Score | — | Unknown status | Device: PerFuse Percutaneous Decompression System, BioCUE Platelet Concentration System | Avascular Necrosis of the Femoral Head | 100 | Mar 2016 | 2020-12-08actual | — | 2021-10-20 |
| ZBH | Zimmer Biomet | $18.9B | Multi Centre Study on TESS V2 Shoulder SystemNCT03431857results2021-10-19observationalConstant Shoulder Score | — | Completed | Device: TESS V2 | Osteoarthritis Shoulder, Fracture, Rheumatoid Arthritis, Avascular Necrosis, Rotator Cuff Tear, Revision | 106 | 2010-10-20 | 2015-12-31actual | — | 2021-10-19 |
| ZBH | Zimmer Biomet | $18.9B | LPS Flex Porous Femoral ComponentsNCT01462240observationalSurvivorship | — | Withdrawnsponsor's stated reason: Suspended pending internal review/direction of the company's focus. | Device: LPS Flex Porous Femoral Components | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Poly Arthritis, Collagen Disorders, Avascular Necrosis of Femoral Condyle | 0 | 2008-05-20 | Mar 2012 | — | 2021-08-24 |
| ZBH | Zimmer Biomet | $18.9B | Avenir Müller Hip Stem Post Market Surveillance StudyNCT04079127results2020-06-23observationalEvaluation of Pain and Functional Performance Determined by the Harris Hip Score | — | Completed | Device: Patients who met the inclusion/exclusion criteria to receive the Avenir Müller stem. | Osteoarthritis, Hip, Rheumatoid Arthritis, Fracture of Hip, Dislocated Hip, Osteonecrosis, Post-traumatic; Arthrosis, Subluxation Hip | 150 | 2010-01-09 | 2019-06-29actual | — | 2021-05-14 |
| ZBH | Zimmer Biomet | $18.9B | Oxford Signature vs. Conventional Global StudyNCT01763684results2021-04-23Percentage of Knees Achieving Optimal Alignment | Not applicable | Terminatedsponsor's stated reason: Due to slow enrollment and not being able to reach the primary endpoint | Device: Signature Custom Guides · Procedure: Conventional Instrumentation | Osteoarthritis, Osteoarthritis, Knee, Osteonecrosis | 266 | Sep 2012 | Aug 2016actual | — | 2021-04-23 |
| ZBH | Zimmer Biomet | $18.9B | Maxera Large Cups - CanadaNCT04348968observationalImplant survival based on removal or intended removal of the device and determined using the Kaplan-Meier method | — | Terminatedsponsor's stated reason: The notified body does not require data anymore and recruitment did not start. The study was thus terminated after approval from the investigator and the local ethical committee. | Device: Total hip arthroplasty | Degenerative Joint Disease of Hip, Osteoarthritis, Hip, Avascular Necrosis of Hip, Post-Traumatic Osteoarthritis of Hip, Congenital Dysplasia of the Hip, Joint Diseases, Rheumatoid Arthritis of Hip | 20 | 2021-03-01 | 2021-03-25actual | — | 2021-04-05 |
| ZBH | Zimmer Biomet | $18.9B | PMCF Study on the Safety and Performance of the Alloclassic Variall Cup Ceramic Bearing System in Total Hip ArthroplastyNCT03672370results2021-01-14observationalClinical Success Will be Based on the Harris Hip Scoring System | — | Terminatedsponsor's stated reason: Study terminated as CE marks of the devices used have not been renewed. | — | Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Posttraumatic Arthritis | 100 | 2015-03-24 | 2019-05-14actual | — | 2021-01-14 |
| ZBH | Zimmer Biomet | $18.9B | PMCF Study of the CLS Brevius Stem With Kinectiv TechnologyNCT03410940observationalImplant survivorship is assessed counting the number of implant revisions | — | Terminatedsponsor's stated reason: The production of the device was stopped due to economic reasons. Basic post-market surveillance activities will be continued. | Device: CLS Brevius stem with Kinectiv technology | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Femoral Neck Fractures, Prosthesis Failure | 223 | 2011-01-07 | 2019-04-08actual | — | 2020-12-17 |
| ZBH | Zimmer Biomet | $18.9B | Post Market Clinical Follow-Up of the Zimmer Stafit Acetabular SystemNCT04079114results2020-06-30observationalImplant Survival | — | Terminatedsponsor's stated reason: Stafit Acetabular System not CE marked anymore | Device: Patients who received the Stafit Acetabular System | Osteoarthritis, Hip, Fracture of Hip, Avascular Necrosis of Hip, Dislocated Hip, Osteonecrosis, Post-traumatic; Arthrosis, Rheumatoid Arthritis, Subluxation Hip | 166 | 2011-04-28 | 2017-01-24actual | — | 2020-06-30 |
| ZBH | Zimmer Biomet | $18.9B | A Clinical Investigation of ArComXL® Polyethylene in Total Hip ReplacementNCT00698152observationalIncidence of revisions and removals | — | Completed | — | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis | 149 | 2006-01-23 | 2016-01-15actual | — | 2020-03-30 |
| ZBH | Zimmer Biomet | $18.9B | Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral DensityNCT02087436Bone Mineral Density | Not applicable | Completed | Device: Taperloc Complete Microplasty, Taperloc Complete Standard | Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Rheumatoid Arthritis, Legg-Perthes Disease | 100 | Mar 2013 | Jul 2014actual | — | 2020-01-09 |
| VCEL | Vericel Corporation | $2.3B | Ixmyelocel-T Treatment of Patients With Osteonecrosis of the Femoral HeadNCT00505219The progression of patients with UPenn Stage IIB or IIC disease to a more severe stage based on all available x-ray and MRI imaging. Patients who have a definitive procedure but do not have a valid assessment will be considered to have progressed. | Phase 3 | Completed | Biological: Ixmyelocel-T · Other: Standard of Care Only | Osteonecrosis | 11 | Sep 2007 | Sep 2010actual | — | 2019-10-21 |
| ZBH | Zimmer Biomet | $18.9B | A Study on M2a Magnum Total Hip ArthroplastyNCT01010763results2019-06-21Range of Motion | Not applicable | Completed | Device: Total Hip Arthroplasty | Degenerative Joint Disease, Avascular Necrosis | 184 | Nov 2009 | 2017-02-28actual | — | 2019-06-21 |
| ZBH | Zimmer Biomet | $18.9B | Outcomes Study of the TM Humeral Stem Used in Primary, Total or Hemi Shoulder ArthroplastyNCT01480453observationalSurvivorship | — | Terminatedsponsor's stated reason: Business decision was made to remove the CE mark from this product, thus prompting the closing of this study. | Device: Trabecular Metal Humeral Stem | Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Ununited Humeral Head Fracture, Irreducible 3- and 4-part Proximal Humeral Fractures, Avascular Necrosis | 67 | 2011-01-02 | 2018-12-31actual | — | 2019-03-26 |
| ZBH | Zimmer Biomet | $18.9B | A Prospective Clinical Study On A Total Hip Resurfacing SystemNCT00604734Harris Hip Score, Device Revision/Removal, Radiographic Evaluation | Not applicable | Completed | Device: ReCap Total Hip Resurfacing System | Arthritis, Avascular Necrosis | 280 | Oct 2004 | Oct 2007actual | — | 2019-02-11 |
| ZBH | Zimmer Biomet | $18.9B | Gender Solutions Natural Knee Post-Market StudyNCT01463566observationalSurvivorship | — | Withdrawnsponsor's stated reason: Suspended pending internal review/direction of the company's focus. | Device: Zimmer Gender(R) Solutions(TM) Natural-Knee(R) Flex System | Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis, Osteonecrosis, Varus or Valgus Deformities | 0 | Jan 2012 | Jul 2024 | — | 2019-01-09 |
| ZBH | Zimmer Biomet | $18.9B | A Comparison of Two Different Surgical Techniques for Total Hip ResurfacingNCT00750984RSA | Not applicable | Completed | Procedure: Anterolateral approach, Posterior approach · Device: ReCap Total Hip Resurfacing, ReCap Total Hip Resurfacing | Arthritis, Avascular Necrosis | 49 | Sep 2008 | Jul 2013actual | — | 2018-01-11 |
| ZBH | Zimmer Biomet | $18.9B | Cementless Oxford Partial Knee Controlled Observational StudyNCT02350049observationalComposite Endpoint- Safety & Efficacy (Radiographic Success, American Knee Society Score, Absence of Revision / Removal / Unanticipated Adverse Device Affects) | — | Completed | — | Osteoarthritis, Avascular Necrosis | 391 | Nov 2014 | Mar 2016actual | — | 2017-12-08 |
| ZBH | Zimmer Biomet | $18.9B | A Clinical Evaluation of Metal Ion Release From Metal-on-Metal Cementless Total Hip ArthroplastyNCT00757354concentration of Cobalt, Chromium and Molybdenum ions in urine | Not applicable | Completed | Procedure: Metal on Metal cementless hip | Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Rheumatoid Arthritis | 77 | Jun 2012 | Mar 2014actual | — | 2017-06-19 |
| NVS | Novartis | — | Zoledronic Acid Treatment of Spontaneous Osteonecrosis of the KneeNCT00477217Changes from baseline after 3 months in a) knee pain scores (using the KOOS pain subscale), and b) volume of osteonecrotic lesion (indicated by bone marrow oedema) on MRI. | Phase 2 | Withdrawn | Drug: Zoledronic acid | Osteonecrosis | 0 | Jan 2008 | May 2009actual | — | 2016-09-23 |
| ZBH | Zimmer Biomet | $18.9B | Avascular Necrosis (AVN) Long-Term Follow-upNCT00833430observationalSafety, Efficacy and longevity of device with patient as opposed to conventional total hip replacement | — | Terminated | — | Avascular Necrosis, Femoral Head Collapse | 35 | Jun 2006 | Feb 2013actual | — | 2016-02-19 |
| ZBH | Zimmer Biomet | $18.9B | Trilogy AB Acetabular Hip System Post Approval StudyNCT00715026results2014-11-26Harris Hip Score | Phase 4 | Terminatedsponsor's stated reason: Sponsor business decision unrelated to clinical performance. | Device: Trilogy AB Acetabular Hip Implant System | Osteoarthritis, Avascular Necrosis, Congenital Hip Dysplasia, Traumatic Arthritis | 31 | Apr 2009 | Jun 2012actual | — | 2014-11-26 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
How Avascular Necrosis is matched — 8 exact registry spellings
A study is on this page when its ClinicalTrials.gov record names one of these conditions exactly (letter case aside). Nothing is matched by substring or stem, so a longer condition that merely contains one of these words is a different page. The list was curated by hand and last measured 2026-08-19; a spelling filed by only one study was not curated, so the counts here are a floor rather than the registry's own total for the disease.
- Avascular Necrosis
- Avascular Necrosis of Hip
- Osteonecrosis
- Avascular Necrosis of the Femoral Condyle
- Avascular Necrosis of Femoral Condyle
- Avascular Necrosis of the Femoral Head
- Avascular Necrosis of Bone of Hip
- Collagen Disorders and/or Avascular Necrosis of the Femoral Condyle
Permalink · All conditions · Catalyst calendar · Every registered study · Search the whole pipeline for “Avascular Necrosis” (a text search, wider than this page)