PRAX — blockholders· Praxis Precision Medicines, Inc.
Everyone who has reported crossing 5% of this issuer inside the capture window — Schedule 13D (active intent, with its Item-4 purpose) and Schedule 13G (passive by rule) kept apart — each with its full amendment chain and, in the fold, the cover page's sole and shared voting and dispositive power per reporting person. Percents are each group's own as-filed figures and do not add up across filers: two filers can report the same shares.
Filed passively under Rule 13d-1(b) (qualified institution), (c) (passive investor) or (d) (exempt). A 13G filer is not an activist and files no purpose statement.
| Filer | Form | % of class | Change | Shares | Filed | Chain | Control | Filing |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 13G/A No. 3QII | 12.3% | ▼ -0.1pp | 2,763,859 | 2025-11-14 | 4 | SEC ↗ | |
| FMR LLC | 13G/A No. 1QII | 7.7% | ▲ +2.3pp | 2,156,343 | 2026-05-06 | 2 | SEC ↗ | |
| Perceptive Advisors LLC | 13G/A No. 1Passive | 7.2% | ▲ +0.51pp | 1,995,986 | 2026-02-17 | 4 | SEC ↗ | |
| Baker Bros. Advisors LP | 13GQII | 6.3% | NEW | 1,753,198 | 2026-05-15 | 1 | SEC ↗ | |
| ORBIS INVESTMENT MANAGEMENT LTD | 13G/A No. 2QII | 5.5% | ▼ -3.4pp | 1,526,680 | 2026-08-14 | 3 | SEC ↗ | |
| Vanguard Capital Management | 13GQII | 5.09% | NEW | 1,419,323 | 2026-04-30 | 1 | SEC ↗ | |
| Venrock Healthcare Capital Partners III, L.P. | 13G/A No. 4Passive | 4.9% | ▼ -1.2pp | 1,016,497 | 2025-05-15 | 2 | SEC ↗ | |
| T. Rowe Price Associates, Inc. | 13G/A No. 1QII | 4.8% | first captured | 1,003,545 | 2025-11-14 | 1 | SEC ↗ | |
| Soleus Capital Master Fund, L.P. | 13G/A No. 1Passive | 4.6% | ▼ -0.4pp | 966,740 | 2025-08-05 | 2 | SEC ↗ | |
| Capital Research Global Investors | 13G/A No. 1QII | 4.2% | first captured | 853,746 | 2025-05-13 | 1 | SEC ↗ |
Source: SEC EDGAR Schedule 13D/G structured XML (public domain) · newest filing 2026-08-14 · capture 2024-01-10 → 2026-08-21 reported positions only — not a portfolio
Voting is not disposition. Each reporting person's cover page splits its holding into VOTING power (sole / shared) and DISPOSITIVE power (sole / shared). Voting and dispositive totals are summed WITHIN a person only — never across persons, because a group's members report overlapping interests in the same shares and the filing's aggregate is not their sum. Where a person's voting total is below its reported aggregate, the difference is shares it reports beneficial ownership of with no voting power reported; it is shown as a gap, never as a second position.
Percent is as filed. Percent is the filing's own percent of class, as filed (0–100). It's the reporting group's figure — not summed across filers, not recomputed against shares outstanding, not rescaled. Share counts are as filed and never subtracted across filings (a split would make that meaningless); the only change we show is the change in the as-filed percent against the prior captured filing.
We never call an amendment “new”. A filing is 'first captured' when we hold nothing earlier for that company + filer. On an amendment that means the original predates our window, not that the position is new — so we never badge an amendment 'new,' even when the raw data says so.
Escalations. An escalation is a filer moving from a passive 13G to an active 13D on the same company — telling the SEC it may now seek to influence control. It's a lower bound: a 13G filed before our window began is invisible and never guessed. If the 13D leg is a 13D/A, an earlier 13D predates our window, so the crossing shown is the first one visible inside it, not necessarily the filer's first.
Parsed Schedule 13D/G XML (events.db schedule_13dg + schedule_13dg_persons). 13D = active intent; 13G filers report passively under Rule 13d-1(b) QII / (c) Passive / (d) Exempt and are never activists. Percents are the reporting group's own as-filed figures and are NOT additive across filers — two filers can report the same shares. Structured 13D/13G coverage starts December 2024 (SEC XML mandate).