Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-01-12 | Galbraith Kenneth | Director,Officer | −Sell | 30,424 | $22.67 | $689,712 |
| 2026-01-12 | Galbraith Kenneth | Director,Officer | +Exercise | 64,000 | — | — |
| 2026-01-12 | Moore Paul Andrew | Officer | −Sell | 9,560 | $22.67 | $216,725 |
| 2026-01-12 | Moore Paul Andrew | Officer | +Exercise | 17,666 | — | — |
| 2026-01-12 | Smith Jeffrey T L | Officer | −Sell | 9,310 | $22.67 | $211,058 |
| 2026-01-12 | Smith Jeffrey T L | Officer | +Exercise | 17,666 | — | — |
| 2026-01-12 | Hollywood Mark | Officer | −Sell | 6,120 | $22.67 | $138,740 |
| 2026-01-12 | Hollywood Mark | Officer | +Exercise | 17,666 | — | — |
| 2026-01-06 | PATTERSON LEONE D | Officer | +Grant | 459 | $10.55 | $4,842 |
| 2026-01-05 | Moore Paul Andrew | Officer | +Exercise | 20,000 | — | — |
| 2026-01-05 | Moore Paul Andrew | Officer | +Exercise | 17,168 | — | — |
| 2026-01-05 | Moore Paul Andrew | Officer | −Sell | 9,289 | $25.10 | $233,154 |
| 2026-01-05 | Moore Paul Andrew | Officer | −Sell | 10,821 | $25.10 | $271,607 |
| 2026-01-05 | Galbraith Kenneth | Director,Officer | +Exercise | 66,666 | — | — |
| 2026-01-05 | Galbraith Kenneth | Director,Officer | −Sell | 22,657 | $25.10 | $568,691 |
| 2026-01-05 | Galbraith Kenneth | Director,Officer | −Sell | 31,686 | $25.10 | $795,319 |
| 2026-01-05 | Galbraith Kenneth | Director,Officer | +Exercise | 47,668 | — | — |
| 2026-01-05 | Smith Jeffrey T L | Officer | −Sell | 10,538 | $25.10 | $264,504 |
| 2026-01-05 | Smith Jeffrey T L | Officer | +Exercise | 20,000 | — | — |
| 2025-12-22 | Galbraith Kenneth | Director,Officer | +Exercise | 100,000 | — | — |
| 2025-12-22 | Galbraith Kenneth | Director,Officer | −Sell | 47,528 | $27.02 | $1M |
| 2025-08-12 | Ciongoli Gregory Austin | Director | +Grant | 415,000 | $12.02 | $5M |
| 2025-06-26 | NODELMAN OLEG | Director,TenPercentOwner | −Tax w/h | 41 | $12.71 | $521 |
| 2025-06-26 | NODELMAN OLEG | Director,TenPercentOwner | +Exercise | 5,086,480 | — | — |
| 2025-05-19 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 5,919 | $11.78 | $69,726 |
| 2025-05-15 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 49,502 | $11.43 | $565,808 |
| 2025-04-17 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 54,760 | $11.52 | $630,835 |
| 2025-04-16 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 73,953 | $11.16 | $825,315 |
| 2025-04-04 | NODELMAN OLEG | Director,TenPercentOwner | +Buy | 196,438 | $11.17 | $2M |
| 2025-04-03 | NODELMAN OLEG | Director,TenPercentOwner | +Buy | 120,770 | $11.84 | $1M |
| 2025-04-02 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 74,360 | $11.85 | $881,166 |
| 2025-04-01 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 48,658 | $11.60 | $564,433 |
| 2025-03-31 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 4,397 | $11.75 | $51,665 |
| 2025-03-26 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 43,848 | $12.24 | $536,700 |
| 2025-03-25 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 53,501 | $12.91 | $690,698 |
| 2025-03-24 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 22,689 | $13.08 | $296,772 |
| 2025-03-21 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 31,033 | $12.78 | $396,602 |
| 2025-03-20 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 73,476 | $12.93 | $950,045 |
| 2025-03-19 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 58,306 | $12.64 | $736,988 |
| 2025-03-18 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 113,880 | $12.65 | $1M |
| 2025-03-17 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 56,277 | $12.23 | $688,268 |
| 2025-03-13 | NODELMAN OLEG | Director,TenPercentOwner | +Buy | 468,356 | $12.48 | $6M |
| 2025-03-12 | NODELMAN OLEG | Director,TenPercentOwner | +Buy | 292,934 | $12.25 | $4M |
| 2025-03-11 | NODELMAN OLEG | Director,TenPercentOwner | +Buy | 320,690 | $11.49 | $4M |
| 2025-01-17 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 19,748 | $13.87 | $273,905 |
| 2025-01-16 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 121,681 | $13.89 | $2M |
| 2025-01-15 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 39,029 | $14.01 | $546,796 |
| 2025-01-14 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 54,500 | $13.56 | $739,020 |
| 2025-01-13 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 74,125 | $13.39 | $992,534 |
| 2025-01-10 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 204,098 | $13.13 | $3M |
| 2025-01-08 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 21,021 | $14.07 | $295,765 |
| 2025-01-06 | Smith Jeffrey T L | Officer | −Sell | 11,110 | $14.92 | $165,761 |
| 2025-01-06 | Smith Jeffrey T L | Officer | +Exercise | 20,000 | — | — |
| 2025-01-06 | Galbraith Kenneth | Director,Officer | +Exercise | 47,666 | — | — |
| 2025-01-06 | Galbraith Kenneth | Director,Officer | −Sell | 33,406 | $14.92 | $498,418 |
| 2025-01-06 | Galbraith Kenneth | Director,Officer | +Exercise | 66,666 | — | — |
| 2025-01-06 | Galbraith Kenneth | Director,Officer | −Sell | 23,885 | $14.92 | $356,364 |
| 2025-01-06 | Moore Paul Andrew | Officer | +Exercise | 17,166 | — | — |
| 2025-01-06 | Moore Paul Andrew | Officer | −Sell | 9,792 | $14.92 | $146,097 |
| 2025-01-06 | Moore Paul Andrew | Officer | −Sell | 11,408 | $14.92 | $170,207 |
| 2025-01-06 | Moore Paul Andrew | Officer | +Exercise | 20,000 | — | — |
| 2025-01-02 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 157,880 | $14.78 | $2M |
| 2024-12-31 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 146,501 | $14.57 | $2M |
| 2024-12-30 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 58,988 | $14.47 | $853,556 |
| 2024-12-27 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 101,659 | $14.49 | $1M |
| 2024-12-26 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 16,692 | $14.38 | $240,031 |
| 2024-12-24 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 11,958 | $14.12 | $168,847 |
| 2024-12-23 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 251,502 | $14.25 | $4M |
| 2024-12-20 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 704,488 | $14.08 | $10M |
| 2024-12-19 | EcoR1 Capital, LLC | Director,TenPercentOwner | +Buy | 298,818 | $13.53 | $4M |
| 2024-01-08 | Moore Paul Andrew | Officer | −Sell | 2,339 | $11.22 | $26,244 |
| 2024-01-08 | Astle Christopher | Officer | −Sell | 1,431 | $11.22 | $16,056 |
| 2024-01-08 | Galbraith Kenneth | Director,Officer | −Sell | 5,706 | $11.22 | $64,021 |
| 2024-01-05 | Moore Paul Andrew | Officer | −Sell | 7,460 | $10.65 | $79,449 |
| 2024-01-05 | Moore Paul Andrew | Officer | +Exercise | 17,166 | — | — |
| 2024-01-05 | Astle Christopher | Officer | −Sell | 4,563 | $10.65 | $48,596 |
| 2024-01-05 | Astle Christopher | Officer | +Exercise | 10,500 | — | — |
| 2024-01-05 | Galbraith Kenneth | Director,Officer | −Sell | 18,198 | $10.65 | $193,809 |
| 2024-01-05 | Galbraith Kenneth | Director,Officer | +Exercise | 47,666 | — | — |
| 2023-12-11 | Astle Christopher | Officer | +Exercise | 1,550 | — | — |
| 2023-12-11 | Astle Christopher | Officer | −Sell | 886 | $9.13 | $8,089 |
| 2023-06-16 | EcoR1 Capital, LLC | TenPercentOwner | +Buy | 3,350,000 | $8.12 | $27M |
| 2023-03-28 | EcoR1 Capital, LLC | TenPercentOwner | +Buy | 200,000 | $8.00 | $2M |
| 2023-03-10 | Klompas Neil A | Officer | −Sell | 2,977 | $7.83 | $23,310 |
| 2023-03-10 | Klompas Neil A | Officer | +Exercise | 2,500 | — | — |
| 2023-03-10 | Klompas Neil A | Officer | +Exercise | 2,708 | — | — |
| 2023-01-20 | EcoR1 Capital, LLC | TenPercentOwner | +Buy | 163,400 | $9.88 | $2M |
| 2023-01-19 | EcoR1 Capital, LLC | TenPercentOwner | +Buy | 144,100 | $9.49 | $1M |
| 2023-01-18 | EcoR1 Capital, LLC | TenPercentOwner | +Buy | 203,000 | $10.00 | $2M |
| 2023-01-17 | EcoR1 Capital, LLC | TenPercentOwner | +Buy | 440,000 | $9.80 | $4M |
| 2023-01-13 | EcoR1 Capital, LLC | TenPercentOwner | +Buy | 342,100 | $9.81 | $3M |
| 2023-01-11 | EcoR1 Capital, LLC | TenPercentOwner | +Buy | 106,300 | $7.87 | $836,581 |
| 2023-01-10 | EcoR1 Capital, LLC | TenPercentOwner | +Buy | 920,000 | $7.65 | $7M |
| 2022-12-12 | Astle Christopher | Officer | +Exercise | 1,550 | — | — |
| 2022-12-12 | Astle Christopher | Officer | −Sell | 887 | $6.01 | $5,331 |
| 2022-12-12 | Astle Christopher | Officer | +Exercise | 1,550 | — | — |
| 2022-12-12 | Astle Christopher | Officer | −Sell | 887 | $6.01 | $5,331 |
| 2022-11-10 | Josephson Neil | Officer | −Sell | 2,475 | $8.10 | $20,048 |
| 2022-11-10 | Josephson Neil | Officer | +Exercise | 5,885 | — | — |
| 2022-11-10 | Josephson Neil | Officer | −Sell | 2,475 | $8.10 | $20,048 |
| 2022-11-10 | Josephson Neil | Officer | +Exercise | 5,885 | — | — |
| 2022-11-10 | Josephson Neil | Officer | −Sell | 2,475 | $8.10 | $20,048 |
| 2022-11-10 | Josephson Neil | Officer | +Exercise | 5,885 | — | — |
| 2022-10-13 | Redmile Group, LLC | TenPercentOwner | +Grant | 30,481 | $5.03 | $153,319 |
| 2022-10-13 | Redmile Group, LLC | TenPercentOwner | +Buy | 30,481 | $5.03 | $153,319 |
| 2022-07-05 | Klompas Neil A | Officer | +Grant | 1,525 | $4.51 | $6,878 |
| 2022-07-05 | Josephson Neil | Officer | +Grant | 1,525 | $4.51 | $6,878 |
| 2022-03-10 | Josephson Neil | Officer | +Exercise | 729 | — | — |
| 2022-03-10 | Josephson Neil | Officer | +Exercise | 1,666 | — | — |
| 2022-03-10 | Klompas Neil A | Officer | −Sell | 2,979 | $6.88 | $20,496 |
| 2022-03-10 | Klompas Neil A | Officer | +Exercise | 2,708 | — | — |
| 2022-03-10 | Klompas Neil A | Officer | +Exercise | 2,500 | — | — |
| 2022-01-07 | Klompas Neil A | Officer | +Grant | 277 | $13.94 | $3,861 |
| 2022-01-07 | Polverino Anthony J. | Officer | +Grant | 74 | $13.94 | $1,032 |
| 2022-01-07 | Josephson Neil | Officer | +Grant | 65 | $13.94 | $906 |
| 2022-01-07 | Josephson Neil | Officer | +Buy | 1,400 | $14.27 | $19,978 |
| 2022-01-07 | Josephson Neil | Officer | +Buy | 3,600 | $14.28 | $51,408 |
| 2021-08-31 | Polverino Anthony J. | Officer | +Exercise | 4,900 | $15.00 | $73,500 |
| 2021-07-16 | Tehrani Ali | Director,Officer | +Exercise | 41,191 | $4.26 | $175,474 |
| 2021-07-16 | Tehrani Ali | Director,Officer | −Sell | 41,191 | $36.00 | $1M |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
