Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-02-15 | Schallenberger Mark A. | Officer | −Tax w/h | 7,709 | $0.58 | $4,471 |
| 2026-01-15 | Neils Scott C | Officer | −Tax w/h | 8,084 | $0.65 | $5,255 |
| 2025-11-15 | Neils Scott C | Officer | +Grant | 263,291 | — | — |
| 2025-11-15 | Schallenberger Mark A. | Officer | +Grant | 292,253 | — | — |
| 2025-11-15 | Browne Sean E | Director,Officer | +Grant | 394,937 | — | — |
| 2025-11-15 | Lipschultz Tyler | Director | +Grant | 158,228 | — | — |
| 2025-11-15 | JAIN ABHINAV | Director | +Grant | 158,228 | — | — |
| 2025-11-15 | BAKEWELL JOHN K | Director | +Grant | 158,228 | — | — |
| 2025-11-15 | Beeson Jonn R. | Director | +Grant | 158,228 | — | — |
| 2025-11-15 | Vizirgianakis Stavros G. | Director | +Grant | 553,797 | — | — |
| 2025-11-15 | BAKEWELL JOHN K | Director | +Grant | 158,228 | — | — |
| 2025-08-15 | Neils Scott C | Officer | −Tax w/h | 34,131 | $0.63 | $21,503 |
| 2025-08-15 | Browne Sean E | Director,Officer | −Tax w/h | 10,605 | $0.63 | $6,681 |
| 2025-04-10 | Orbimed ROF II LLC | TenPercentOwner | −Sell | 56,004,974 | $0.42 | $24M |
| 2025-04-10 | Orbimed ROF II LLC | TenPercentOwner | −Sell | 17,109,618 | $0.42 | $7M |
| 2025-01-15 | Neils Scott C | Officer | −Tax w/h | 7,986 | $0.53 | $4,233 |
| 2024-10-15 | Browne Sean E | Director,Officer | −Tax w/h | 105,442 | $0.59 | $62,211 |
| 2024-08-15 | Browne Sean E | Director,Officer | −Tax w/h | 10,606 | $0.60 | $6,364 |
| 2024-08-15 | Neils Scott C | Officer | −Tax w/h | 34,132 | $0.60 | $20,479 |
| 2024-08-15 | Brandt Kevin D | Officer | −Tax w/h | 56,333 | $0.60 | $33,800 |
| 2024-08-15 | BAKEWELL JOHN K | Director | +Grant | 162,162 | — | — |
| 2024-08-15 | Beeson Jonn R. | Director | +Grant | 162,162 | — | — |
| 2024-08-15 | McNamara Robert | Director | +Grant | 162,162 | — | — |
| 2024-08-15 | MITCHELL-KELLER LORI D | Director | +Grant | 162,162 | — | — |
| 2024-08-15 | Vizirgianakis Stavros G. | Director | +Grant | 243,243 | — | — |
| 2024-08-15 | Vizirgianakis Stavros G. | Director | +Grant | 505,405 | — | — |
| 2024-04-03 | Neils Scott C | Officer | +Grant | 177,551 | — | — |
| 2024-04-03 | Schallenberger Mark A. | Officer | +Grant | 177,551 | — | — |
| 2024-04-03 | Browne Sean E | Director,Officer | +Grant | 731,632 | — | — |
| 2024-04-03 | Brandt Kevin D | Officer | +Grant | 184,209 | — | — |
| 2024-04-03 | Schallenberger Mark A. | Officer | +Grant | 173,469 | — | — |
| 2024-01-16 | Neils Scott C | Officer | −Tax w/h | 7,986 | $1.09 | $8,705 |
| 2023-11-17 | Brandt Kevin D | Officer | +Buy | 41,670 | $1.20 | $50,004 |
| 2023-10-15 | Browne Sean E | Director,Officer | −Tax w/h | 111,721 | $1.08 | $120,659 |
| 2023-10-15 | Browne Sean E | Director,Officer | −Tax w/h | 105,442 | $1.08 | $113,877 |
| 2023-08-15 | BAKEWELL JOHN K | Director | +Grant | 145,180 | — | — |
| 2023-08-15 | Beeson Jonn R. | Director | +Grant | 145,180 | — | — |
| 2023-08-15 | McNamara Robert | Director | +Grant | 145,180 | — | — |
| 2023-08-15 | MITCHELL-KELLER LORI D | Director | +Grant | 145,180 | — | — |
| 2023-08-15 | Vizirgianakis Stavros G. | Director | +Grant | 217,770 | — | — |
| 2023-08-15 | Brandt Kevin D | Officer | −Tax w/h | 49,880 | $1.18 | $58,858 |
| 2023-08-15 | Brandt Kevin D | Officer | +Grant | 120,499 | — | — |
| 2023-08-15 | Browne Sean E | Director,Officer | +Grant | 174,216 | — | — |
| 2023-08-15 | Neils Scott C | Officer | −Tax w/h | 25,246 | $1.18 | $29,790 |
| 2023-08-15 | Neils Scott C | Officer | +Grant | 116,144 | — | — |
| 2023-08-15 | Schallenberger Mark A. | Officer | +Grant | 116,144 | — | — |
| 2023-06-15 | MITCHELL-KELLER LORI D | Director | +Grant | 45,782 | — | — |
| 2023-05-15 | Beeson Jonn R. | Director | +Grant | 52,049 | — | — |
| 2023-02-15 | Schallenberger Mark A. | Officer | +Grant | 89,000 | — | — |
| 2023-01-18 | Neils Scott C | Officer | −Sell | 8,673 | $0.61 | $5,291 |
| 2022-11-15 | Vizirgianakis Stavros G. | Director | +Grant | 144,639 | — | — |
| 2022-10-19 | Browne Sean E | Director,Officer | −Sell | 51,100 | $0.62 | $31,682 |
| 2022-10-18 | Browne Sean E | Director,Officer | −Sell | 80,000 | $0.68 | $54,400 |
| 2022-10-07 | Vizirgianakis Stavros G. | Director | +Buy | 2,264,861 | $0.48 | $1M |
| 2022-08-25 | Vizirgianakis Stavros G. | Director | +Grant | 70,776 | — | — |
| 2022-08-17 | Neils Scott C | Officer | −Sell | 1,270 | $0.48 | $610 |
| 2022-08-17 | Brandt Kevin D | Officer | −Sell | 4,300 | $0.48 | $2,064 |
| 2022-08-16 | Neils Scott C | Officer | −Sell | 5,100 | $0.48 | $2,448 |
| 2022-08-16 | Brandt Kevin D | Officer | −Sell | 18,700 | $0.49 | $9,163 |
| 2022-08-15 | Rizzo Matthew | Director,TenPercentOwner | +Grant | 215,415 | — | — |
| 2022-08-15 | Eggenberg Michael | Director,TenPercentOwner | +Grant | 215,415 | — | — |
| 2022-08-15 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | +Other | 215,415 | — | — |
| 2022-08-15 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | +Other | 215,415 | — | — |
| 2022-08-15 | BAKEWELL JOHN K | Director | +Grant | 215,415 | — | — |
| 2022-08-15 | McNamara Robert | Director | +Grant | 215,415 | — | — |
| 2022-08-15 | Peters Jeffrey J | Director | +Grant | 215,415 | — | — |
| 2022-08-15 | Neils Scott C | Officer | +Grant | 251,895 | — | — |
| 2022-08-15 | Brandt Kevin D | Officer | +Grant | 410,079 | — | — |
| 2022-01-15 | Neils Scott C | Officer | +Grant | 88,983 | — | — |
| 2021-10-15 | Browne Sean E | Director,Officer | −Tax w/h | 160,219 | $1.11 | $177,843 |
| 2021-08-15 | JENSEN GREG | Officer | +Grant | 156,250 | — | — |
| 2021-08-15 | Rizzo Matthew | Director | +Grant | 85,337 | — | — |
| 2021-08-15 | Eggenberg Michael | Director | +Grant | 85,337 | — | — |
| 2021-08-15 | McNamara Robert | Director | +Grant | 85,337 | — | — |
| 2021-08-15 | Peters Jeffrey J | Director | +Grant | 85,337 | — | — |
| 2021-08-15 | BAKEWELL JOHN K | Director | +Grant | 85,337 | — | — |
| 2021-08-15 | Brandt Kevin D | Officer | −Tax w/h | 7,169 | $1.20 | $8,603 |
| 2021-08-15 | Brandt Kevin D | Officer | +Grant | 162,109 | — | — |
| 2021-08-15 | Orbimed ROF II LLC | Director,TenPercentOwner | +Other | 85,337 | — | — |
| 2021-08-15 | Orbimed ROF II LLC | Director,TenPercentOwner | +Other | 85,337 | — | — |
| 2021-07-09 | Brandt Kevin D | Officer | −Tax w/h | 8,800 | $1.74 | $15,312 |
| 2020-11-17 | Rizzo Matthew | Director,TenPercentOwner | +Exercise | 1,531,984 | $0.01 | $15,320 |
| 2020-11-17 | Rizzo Matthew | Director,TenPercentOwner | +Exercise | 434,008 | $0.01 | $4,340 |
| 2020-11-17 | Rizzo Matthew | Director,TenPercentOwner | +Exercise | 434,008 | $0.01 | $4,340 |
| 2020-11-17 | Rizzo Matthew | Director,TenPercentOwner | +Exercise | 868,016 | $0.01 | $8,680 |
| 2020-11-17 | Rizzo Matthew | Director,TenPercentOwner | +Exercise | 765,992 | $0.01 | $7,660 |
| 2020-11-17 | Rizzo Matthew | Director,TenPercentOwner | +Exercise | 765,992 | $0.01 | $7,660 |
| 2020-11-17 | Eggenberg Michael | Director,TenPercentOwner | +Exercise | 434,008 | $0.01 | $4,340 |
| 2020-11-17 | Eggenberg Michael | Director,TenPercentOwner | +Exercise | 765,992 | $0.01 | $7,660 |
| 2020-11-17 | Eggenberg Michael | Director,TenPercentOwner | +Exercise | 765,992 | $0.01 | $7,660 |
| 2020-11-17 | Eggenberg Michael | Director,TenPercentOwner | +Exercise | 1,531,984 | $0.01 | $15,320 |
| 2020-11-17 | Eggenberg Michael | Director,TenPercentOwner | +Exercise | 434,008 | $0.01 | $4,340 |
| 2020-11-17 | Eggenberg Michael | Director,TenPercentOwner | +Exercise | 868,016 | $0.01 | $8,680 |
| 2020-11-17 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | +Exercise | 1,531,984 | $0.01 | $15,320 |
| 2020-11-17 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | +Exercise | 434,008 | $0.01 | $4,340 |
| 2020-11-17 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | +Exercise | 434,008 | $0.01 | $4,340 |
| 2020-11-17 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | +Exercise | 868,016 | $0.01 | $8,680 |
| 2020-11-17 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | +Exercise | 765,992 | $0.01 | $7,660 |
| 2020-11-17 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | +Exercise | 765,992 | $0.01 | $7,660 |
| 2020-11-15 | Browne Sean E | Director,Officer | +Grant | 1,468,859 | — | — |
| 2020-10-01 | Orbimed ROF II LLC | Director,TenPercentOwner | +Grant | 11,969,619 | $1.07 | $13M |
| 2020-10-01 | Orbimed ROF II LLC | Director,TenPercentOwner | +Grant | 46,784,775 | $1.07 | $50M |
| 2020-10-01 | Rizzo Matthew | Director,TenPercentOwner | +Grant | 46,784,775 | $1.07 | $50M |
| 2020-10-01 | Rizzo Matthew | Director,TenPercentOwner | +Grant | 11,969,619 | $1.07 | $13M |
| 2020-10-01 | Eggenberg Michael | Director,TenPercentOwner | +Grant | 11,969,619 | $1.07 | $13M |
| 2020-10-01 | Eggenberg Michael | Director,TenPercentOwner | +Grant | 46,784,775 | $1.07 | $50M |
| 2020-08-15 | Brandt Kevin D | Officer | +Grant | 95,183 | — | — |
| 2020-08-15 | JENSEN GREG | Officer | +Grant | 95,183 | — | — |
| 2020-02-05 | BAKEWELL JOHN K | Director | +Grant | 116,197 | — | — |
| 2020-02-05 | McNamara Robert | Director | +Grant | 116,197 | — | — |
| 2020-02-05 | Peters Jeffrey J | Director | +Grant | 116,197 | — | — |
| 2020-02-05 | Rizzo Matthew | Director,TenPercentOwner | +Grant | 70,423 | — | — |
| 2020-02-05 | Eggenberg Michael | Director,TenPercentOwner | +Grant | 70,423 | — | — |
| 2020-02-05 | Orbimed ROF II LLC | Director,TenPercentOwner | +Other | 70,423 | — | — |
| 2020-02-05 | Orbimed ROF II LLC | Director,TenPercentOwner | +Other | 70,423 | — | — |
| 2019-10-30 | Eggenberg Michael | Director,TenPercentOwner | +Grant | 20,833 | — | — |
| 2019-10-30 | Orbimed ROF II LLC | Director,TenPercentOwner | +Other | 20,833 | — | — |
| 2019-10-30 | Orbimed ROF II LLC | Director,TenPercentOwner | +Other | 20,833 | — | — |
| 2019-10-30 | Rizzo Matthew | Director,TenPercentOwner | +Grant | 20,833 | — | — |
| 2019-10-15 | Browne Sean E | Officer | +Grant | 329,044 | — | — |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
