Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-03-26 | Shannon James Samuel | Director | +Buy | 5,000 | $8.79 | $43,950 |
| 2026-01-02 | Frankenfield Christopher James | Officer | −Sell | 7,030 | $0.64 | $4,499 |
| 2026-01-02 | Brennan Kevin M. | Officer | −Sell | 1,826 | $0.64 | $1,169 |
| 2026-01-01 | Russo Rene | Director,Officer | +Exercise | 44,250 | — | — |
| 2026-01-01 | Frankenfield Christopher James | Officer | +Exercise | 19,375 | — | — |
| 2026-01-01 | Brennan Kevin M. | Officer | +Exercise | 5,000 | — | — |
| 2026-01-01 | Luptakova Katarina | Officer | +Exercise | 16,625 | — | — |
| 2025-06-17 | Shannon James Samuel | Director | +Buy | 25,000 | $0.69 | $17,250 |
| 2025-06-16 | Russo Rene | Director,Officer | +Buy | 36,289 | $0.68 | $24,677 |
| 2025-06-16 | Shannon James Samuel | Director | +Buy | 45,000 | $0.69 | $31,050 |
| 2025-01-02 | Brennan Kevin M. | Officer | −Sell | 1,803 | $0.98 | $1,767 |
| 2025-01-02 | Frankenfield Christopher James | Officer | −Sell | 6,954 | $0.98 | $6,815 |
| 2025-01-01 | Brennan Kevin M. | Officer | +Exercise | 5,000 | — | — |
| 2025-01-01 | Russo Rene | Director,Officer | +Exercise | 44,250 | — | — |
| 2025-01-01 | Luptakova Katarina | Officer | +Exercise | 16,625 | — | — |
| 2025-01-01 | Frankenfield Christopher James | Officer | +Exercise | 19,375 | — | — |
| 2024-12-18 | GILEAD SCIENCES, INC. | TenPercentOwner | +Buy | 1,759,978 | $1.04 | $2M |
| 2024-04-02 | GILEAD SCIENCES, INC. | TenPercentOwner | +Buy | 485,250 | $0.76 | $368,790 |
| 2024-02-08 | Atlas Venture Fund XI, L.P. | TenPercentOwner | −Sell | 733 | $0.64 | $469 |
| 2024-02-08 | Atlas Venture Fund XI, L.P. | TenPercentOwner | −Sell | 267 | $0.64 | $171 |
| 2024-01-12 | Atlas Venture Associates Opportunity I, L.P. | TenPercentOwner | −Sell | 1,540 | $0.83 | $1,278 |
| 2024-01-12 | Atlas Venture Associates Opportunity I, L.P. | TenPercentOwner | −Sell | 560 | $0.83 | $465 |
| 2024-01-11 | Atlas Venture Associates Opportunity I, L.P. | TenPercentOwner | −Sell | 569 | $0.87 | $495 |
| 2024-01-11 | Atlas Venture Associates Opportunity I, L.P. | TenPercentOwner | −Sell | 1,566 | $0.87 | $1,362 |
| 2021-12-10 | BCIP Life Sciences Associates, LP | TenPercentOwner | +Buy | 21,812 | $9.56 | $208,523 |
| 2021-12-10 | BCIP Life Sciences Associates, LP | TenPercentOwner | +Buy | 3,188 | $10.24 | $32,645 |
| 2021-12-09 | BCIP Life Sciences Associates, LP | TenPercentOwner | +Buy | 4,011 | $9.84 | $39,468 |
| 2021-12-08 | BCIP Life Sciences Associates, LP | TenPercentOwner | +Buy | 13,458 | $9.62 | $129,466 |
| 2021-10-26 | Alexandria Venture Investments, LLC | TenPercentOwner | +Conversion | 166,423 | — | — |
| 2021-10-26 | Atlas Venture Opportunity Fund I, L.P. | TenPercentOwner | +Buy | 187,500 | $16.00 | $3M |
| 2021-10-26 | Atlas Venture Opportunity Fund I, L.P. | TenPercentOwner | +Conversion | 1,372,998 | — | — |
| 2021-10-26 | Atlas Venture Opportunity Fund I, L.P. | TenPercentOwner | +Conversion | 624,089 | — | — |
| 2021-10-26 | Atlas Venture Opportunity Fund I, L.P. | TenPercentOwner | +Conversion | 548,442 | — | — |
| 2021-10-26 | BAY CITY CAPITAL LLC | TenPercentOwner | +Buy | 312,500 | $16.00 | $5M |
| 2021-10-26 | BAY CITY CAPITAL LLC | TenPercentOwner | +Conversion | 665,696 | — | — |
| 2021-10-26 | BAY CITY CAPITAL LLC | TenPercentOwner | +Conversion | 151,294 | — | — |
| 2021-10-26 | Merck KGaA | TenPercentOwner | +Conversion | 416,060 | — | — |
| 2021-10-26 | Merck KGaA | TenPercentOwner | +Conversion | 264,765 | — | — |
| 2021-10-26 | Rock Springs Capital Master Fund LP | TenPercentOwner | +Conversion | 756,472 | — | — |
| 2021-10-26 | Rock Springs Capital Master Fund LP | TenPercentOwner | +Conversion | 151,294 | — | — |
| 2021-10-26 | Rock Springs Capital Master Fund LP | TenPercentOwner | +Buy | 500,000 | $16.00 | $8M |
| 2021-10-26 | RiverVest Venture Fund IV, L.P. | TenPercentOwner | +Buy | 250,000 | $16.00 | $4M |
| 2021-10-26 | RiverVest Venture Fund IV, L.P. | TenPercentOwner | +Conversion | 832,120 | — | — |
| 2021-10-26 | RiverVest Venture Fund IV, L.P. | TenPercentOwner | +Conversion | 359,324 | — | — |
| 2021-10-26 | Takeda Ventures, Inc. | TenPercentOwner | +Conversion | 1,475,121 | — | — |
| 2021-10-26 | SV7 (IMF) GP LLP | TenPercentOwner | +Conversion | 302,588 | — | — |
| 2021-10-26 | SV7 (IMF) GP LLP | TenPercentOwner | +Conversion | 302,588 | — | — |
| 2021-10-26 | SV7 (IMF) GP LLP | TenPercentOwner | +Conversion | 998,544 | — | — |
| 2021-10-26 | SV7 (IMF) GP LLP | TenPercentOwner | +Conversion | 998,544 | — | — |
| 2021-10-26 | FMR LLC | Other | +Conversion | 789,473 | — | — |
| 2021-10-26 | FMR LLC | Other | +Conversion | 372,215 | — | — |
| 2021-10-26 | FMR LLC | Other | +Conversion | 28,703 | — | — |
| 2021-10-26 | FMR LLC | Other | +Conversion | 686,499 | — | — |
| 2021-10-26 | FMR LLC | Other | +Conversion | 4,465 | — | — |
| 2021-10-26 | FIL Ltd | Other | +Conversion | 218,705 | — | — |
| 2021-10-26 | Deerfield Mgmt L.P. | TenPercentOwnerOther | +Conversion | 756,472 | — | — |
| 2021-10-26 | Deerfield Mgmt L.P. | TenPercentOwnerOther | +Conversion | 756,472 | — | — |
| 2021-10-26 | Deerfield Mgmt L.P. | TenPercentOwnerOther | +Buy | 387,500 | $16.00 | $6M |
| 2021-10-26 | Deerfield Mgmt L.P. | TenPercentOwnerOther | +Buy | 387,500 | $16.00 | $6M |
| 2021-10-26 | SV7 Impact Medicine Fund LP | TenPercentOwner | +Buy | 312,500 | $16.00 | $5M |
| 2021-10-26 | SV7 Impact Medicine Fund LP | TenPercentOwner | +Buy | 312,500 | $16.00 | $5M |
| 2021-10-26 | SV7 Impact Medicine Fund LP | TenPercentOwner | +Conversion | 302,588 | — | — |
| 2021-10-26 | SV7 Impact Medicine Fund LP | TenPercentOwner | +Conversion | 302,588 | — | — |
| 2021-10-26 | SV7 Impact Medicine Fund LP | TenPercentOwner | +Conversion | 998,544 | — | — |
| 2021-10-26 | SV7 Impact Medicine Fund LP | TenPercentOwner | +Conversion | 998,544 | — | — |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
