Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-05-11 | Fairmount Healthcare Fund II L.P. | Director,TenPercentOwner | +Buy | 1,176,470 | $17.00 | $20M |
| 2026-03-03 | Mahoney Stephen F. | Officer | +Exercise | 18,357 | — | — |
| 2026-03-03 | Mahoney Stephen F. | Officer | −Tax w/h | 7,627 | $29.32 | $223,624 |
| 2026-03-03 | Beetham Thomas W. | Officer | −Tax w/h | 3,138 | $29.32 | $92,006 |
| 2026-03-03 | Beetham Thomas W. | Officer | +Exercise | 9,409 | — | — |
| 2026-03-03 | Harmon Seth | Officer | −Tax w/h | 2,091 | $29.32 | $61,308 |
| 2026-03-03 | Harmon Seth | Officer | +Exercise | 6,267 | — | — |
| 2026-03-03 | Tousignant Jennifer | Officer | −Tax w/h | 1,724 | $29.32 | $50,548 |
| 2026-03-03 | Tousignant Jennifer | Officer | +Exercise | 5,169 | — | — |
| 2026-03-03 | Mahoney Stephen F. | Director,Officer | −Tax w/h | 7,408 | $30.19 | $223,648 |
| 2026-03-03 | Tousignant Jennifer | Officer | −Tax w/h | 1,675 | $30.19 | $50,568 |
| 2026-03-03 | Beetham Thomas W. | Officer | −Tax w/h | 3,048 | $30.19 | $92,019 |
| 2026-03-03 | Harmon Seth | Officer | −Tax w/h | 2,031 | $30.19 | $61,316 |
| 2025-12-31 | Tousignant Jennifer | Officer | −Sell | 2,272 | $31.16 | $70,796 |
| 2025-10-23 | Fairmount Healthcare Fund II GP LLC | Director,TenPercentOwner | +Buy | 454,545 | $22.00 | $10M |
| 2025-06-10 | Fairmount Funds Management LLC | Director,TenPercentOwner | +Exercise | 12,500 | $12.31 | $153,875 |
| 2025-06-09 | Fairmount Funds Management LLC | Director,TenPercentOwner | +Exercise | 1,600 | $7.80 | $12,480 |
| 2024-09-27 | Mahoney Stephen F. | Director,Officer | +Buy | 21,400 | $23.33 | $499,262 |
| 2024-09-27 | Beetham Thomas W. | Officer | +Buy | 5,000 | $23.41 | $117,050 |
| 2024-09-13 | Fairmount Healthcare Fund II L.P. | Director,TenPercentOwner | +Buy | 1,600,000 | $18.75 | $30M |
| 2024-03-28 | Fairmount Healthcare Fund II L.P. | Director,TenPercentOwner | +Other | 5,859 | — | — |
| 2024-03-28 | Fairmount Healthcare Fund II L.P. | Director,TenPercentOwner | −Other | 5,859 | — | — |
| 2024-01-22 | Fairmount Healthcare Fund II L.P. | Director,TenPercentOwner,Other | +Buy | 476,190 | $21.00 | $10M |
| 2023-06-16 | Meisner Lara | Officer | +Exercise | 27 | $23.03 | $622 |
| 2023-06-16 | Meisner Lara | Officer | −Sell | 27 | $28.35 | $765 |
| 2023-06-15 | Meisner Lara | Officer | +Exercise | 2,269 | $23.03 | $52,255 |
| 2023-06-15 | Meisner Lara | Officer | −Sell | 2,269 | $28.02 | $63,577 |
| 2023-06-06 | Meisner Lara | Officer | +Exercise | 5,126 | $18.51 | $94,882 |
| 2023-06-06 | Meisner Lara | Officer | −Sell | 5,126 | $25.02 | $128,253 |
| 2023-06-05 | Meisner Lara | Officer | +Exercise | 499 | $18.51 | $9,236 |
| 2023-06-05 | Meisner Lara | Officer | −Sell | 499 | $25.03 | $12,490 |
| 2023-06-02 | Meisner Lara | Officer | −Sell | 1,875 | $24.21 | $45,394 |
| 2023-06-02 | Meisner Lara | Officer | +Exercise | 1,875 | $14.00 | $26,250 |
| 2023-04-12 | Myers Scott Dunseth | Director,Officer | +Buy | 4,000 | $25.37 | $101,480 |
| 2023-03-13 | Myers Scott Dunseth | Director,Officer | +Buy | 5,500 | $29.15 | $160,325 |
| 2023-03-09 | Meisner Lara | Officer | −Sell | 29,971 | $29.07 | $871,257 |
| 2023-02-06 | Myers Scott Dunseth | Director,Officer | +Grant | 250,000 | — | — |
| 2023-02-02 | Violin Jonathan | Director,Officer | −Sell | 50,000 | $36.80 | $2M |
| 2023-02-02 | Violin Jonathan | Director,Officer | +Exercise | 50,000 | $0.15 | $7,500 |
| 2023-02-02 | Violin Jonathan | Director,Officer | −Sell | 50,000 | $36.80 | $2M |
| 2023-01-23 | Meisner Lara | Officer | +Exercise | 1,872 | $14.00 | $26,208 |
| 2023-01-23 | Meisner Lara | Officer | −Sell | 6,843 | $35.66 | $244,021 |
| 2023-01-23 | Meisner Lara | Officer | +Exercise | 4,971 | $23.03 | $114,482 |
| 2023-01-17 | Katz Barrett | Officer | −Sell | 24,853 | $37.21 | $924,780 |
| 2023-01-17 | Katz Barrett | Officer | +Exercise | 24,853 | $23.03 | $572,365 |
| 2023-01-13 | Katz Barrett | Officer | −Sell | 4,147 | $37.01 | $153,480 |
| 2023-01-13 | Katz Barrett | Officer | +Exercise | 4,147 | $23.03 | $95,505 |
| 2023-01-10 | Katz Barrett | Officer | −Sell | 47,377 | $35.30 | $2M |
| 2023-01-10 | Katz Barrett | Officer | +Exercise | 47,377 | $23.03 | $1M |
| 2023-01-09 | Katz Barrett | Officer | −Sell | 12,623 | $33.04 | $417,064 |
| 2023-01-09 | Katz Barrett | Officer | +Exercise | 12,623 | $23.03 | $290,708 |
| 2022-12-21 | Meisner Lara | Officer | −Sell | 16,326 | $29.19 | $476,556 |
| 2022-12-21 | Meisner Lara | Officer | +Exercise | 16,326 | $23.03 | $375,988 |
| 2022-12-20 | Meisner Lara | Officer | −Sell | 600 | $28.07 | $16,842 |
| 2022-12-20 | Meisner Lara | Officer | +Exercise | 600 | $23.03 | $13,818 |
| 2022-12-16 | Meisner Lara | Officer | −Sell | 1,297 | $28.44 | $36,887 |
| 2022-12-16 | Meisner Lara | Officer | +Exercise | 1,297 | $23.03 | $29,870 |
| 2022-12-15 | Meisner Lara | Officer | −Sell | 300 | $28.08 | $8,424 |
| 2022-12-15 | Meisner Lara | Officer | +Exercise | 300 | $23.03 | $6,909 |
| 2022-12-14 | Meisner Lara | Officer | −Sell | 15,656 | $28.12 | $440,247 |
| 2022-12-14 | Meisner Lara | Officer | +Exercise | 15,656 | $23.03 | $360,558 |
| 2022-12-12 | Meisner Lara | Officer | +Exercise | 600 | $23.03 | $13,818 |
| 2022-12-12 | Meisner Lara | Officer | −Sell | 600 | $28.05 | $16,830 |
| 2022-11-15 | Meisner Lara | Officer | +Exercise | 8,125 | $14.00 | $113,750 |
| 2022-11-15 | Meisner Lara | Officer | −Sell | 8,125 | $22.05 | $179,156 |
| 2022-08-17 | Fairmount Healthcare Fund GP LLC | Director,TenPercentOwner | +Buy | 425,531 | $23.50 | $10M |
| 2022-06-01 | Violin Jonathan | Director,Officer | −Sell | 30,000 | $12.20 | $366,000 |
| 2022-05-02 | Violin Jonathan | Director,Officer | −Sell | 30,000 | $13.04 | $391,200 |
| 2022-04-04 | Violin Jonathan | Director,Officer | −Sell | 3,600 | $18.93 | $68,148 |
| 2022-04-01 | Violin Jonathan | Director,Officer | −Sell | 26,400 | $18.92 | $499,488 |
| 2022-03-02 | Violin Jonathan | Director,Officer | −Sell | 11,106 | $17.36 | $192,800 |
| 2022-03-01 | Violin Jonathan | Director,Officer | −Sell | 18,894 | $17.82 | $336,691 |
| 2022-02-03 | Violin Jonathan | Director,Officer | −Sell | 909 | $19.16 | $17,416 |
| 2022-02-02 | Violin Jonathan | Director,Officer | −Sell | 12,340 | $18.47 | $227,920 |
| 2022-02-01 | Violin Jonathan | Director,Officer | −Sell | 16,751 | $19.55 | $327,482 |
| 2021-12-08 | Violin Jonathan | Director,Officer | +Conversion | 627,564 | — | — |
| 2021-09-23 | Frazier Life Sciences Public Fund, L.P. | TenPercentOwner | +Buy | 200,000 | $11.00 | $2M |
| 2021-09-21 | Fairmount Healthcare Fund L.P. | DirectorOther | +Buy | 909,000 | $11.00 | $10M |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
