Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-06-19 | Azelby Robert | Director | +Grant | 5,740 | — | — |
| 2026-06-05 | Lee Sung | Director | +Grant | 570 | — | — |
| 2026-06-05 | Rothenberg Mace | Director | +Grant | 4,000 | — | — |
| 2026-06-05 | Calhoun Lesley Ann | Director | +Grant | 4,000 | — | — |
| 2026-06-05 | Ketchum John B | Director | +Grant | 4,000 | — | — |
| 2026-06-01 | Crystal Adam | Officer | −Sell | 6,140 | $22.25 | $136,615 |
| 2026-06-01 | Crystal Adam | Officer | −Sell | 20,860 | $23.06 | $481,032 |
| 2026-06-01 | Crystal Adam | Officer | +Exercise | 27,000 | $5.20 | $140,400 |
| 2026-05-01 | Gall Matthew | Officer | +Grant | 40,000 | — | — |
| 2026-05-01 | Crystal Adam | Officer | −Sell | 1,100 | $22.00 | $24,200 |
| 2026-05-01 | Crystal Adam | Officer | +Exercise | 27,000 | $5.20 | $140,400 |
| 2026-05-01 | Crystal Adam | Officer | −Sell | 25,900 | $21.19 | $548,821 |
| 2026-04-29 | Lee Sung | Director | +Grant | 12,300 | — | — |
| 2026-04-15 | Crystal Adam | Officer | −Sell | 38,460 | $25.00 | $961,500 |
| 2026-04-15 | Crystal Adam | Officer | +Exercise | 38,460 | $5.20 | $199,992 |
| 2026-04-01 | Crystal Adam | Officer | +Exercise | 27,000 | $5.20 | $140,400 |
| 2026-04-01 | Crystal Adam | Officer | −Sell | 27,000 | $21.20 | $572,400 |
| 2026-03-25 | Crystal Adam | Officer | −Sell | 12,000 | $20.11 | $241,320 |
| 2026-03-25 | Crystal Adam | Officer | +Exercise | 12,000 | $5.20 | $62,400 |
| 2026-03-05 | Crystal Adam | Officer | −Sell | 20,251 | $15.00 | $303,765 |
| 2026-02-25 | Crystal Adam | Officer | −Sell | 54,345 | $12.77 | $693,986 |
| 2026-02-03 | Crystal Adam | Officer | −Sell | 18,251 | $12.26 | $223,757 |
| 2026-02-03 | Crystal Adam | Officer | −Sell | 201 | $12.90 | $2,593 |
| 2026-02-03 | Weber Barbara | Director,Officer | −Sell | 30,186 | $12.26 | $370,080 |
| 2026-02-03 | Weber Barbara | Director,Officer | −Sell | 333 | $12.90 | $4,296 |
| 2026-02-03 | Beckman Daniella | Officer | −Sell | 113 | $12.90 | $1,458 |
| 2026-02-03 | Beckman Daniella | Officer | −Sell | 10,204 | $12.26 | $125,101 |
| 2026-02-02 | Crystal Adam | Officer | +Grant | 47,460 | — | — |
| 2026-02-02 | Weber Barbara | Director,Officer | +Grant | 37,522 | — | — |
| 2026-02-02 | Beckman Daniella | Officer | +Grant | 44,330 | — | — |
| 2026-01-08 | Peters Malte | Director,Officer | +Grant | 350,000 | — | — |
| 2026-01-02 | Lee Sung | Director | +Grant | 10,000 | — | — |
| 2025-10-23 | TRV GP IV, LLC | TenPercentOwner | −Sell | 477,401 | $10.15 | $5M |
| 2025-09-25 | TRV GP IV, LLC | TenPercentOwner | −Sell | 500,000 | $8.02 | $4M |
| 2025-09-16 | TRV GP IV, LLC | TenPercentOwner | −Sell | 363,541 | $7.04 | $3M |
| 2025-09-08 | TRV GP IV, LLC | TenPercentOwner | −Sell | 86,459 | $7.04 | $608,671 |
| 2025-09-05 | TRV GP IV, LLC | TenPercentOwner | −Sell | 642,906 | $7.00 | $5M |
| 2025-08-22 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 302,194 | $7.00 | $2M |
| 2025-08-19 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 1,100,000 | $7.01 | $8M |
| 2025-06-05 | Borisy Alexis | Director | +Grant | 6,250 | — | — |
| 2025-06-05 | Ketchum John B | Director | +Grant | 6,250 | — | — |
| 2025-06-05 | Rothenberg Mace | Director | +Grant | 6,250 | — | — |
| 2025-06-05 | Calhoun Lesley Ann | Director | +Grant | 6,250 | — | — |
| 2025-06-05 | Peters Malte | Director | +Grant | 6,250 | — | — |
| 2025-02-05 | Weber Barbara | Director,Officer | −Sell | 9,013 | $3.16 | $28,481 |
| 2025-02-05 | Crystal Adam | Officer | −Sell | 6,851 | $3.16 | $21,649 |
| 2025-02-05 | Beckman Daniella | Officer | −Sell | 3,948 | $3.16 | $12,476 |
| 2025-02-05 | Barry Douglas | Officer | −Sell | 2,556 | $3.16 | $8,077 |
| 2025-02-04 | Weber Barbara | Director,Officer | −Sell | 9,778 | $2.99 | $29,236 |
| 2025-02-04 | Crystal Adam | Officer | −Sell | 7,432 | $2.99 | $22,222 |
| 2025-02-04 | Beckman Daniella | Officer | −Sell | 4,284 | $2.99 | $12,809 |
| 2025-02-04 | Barry Douglas | Officer | −Sell | 2,774 | $2.99 | $8,294 |
| 2025-02-03 | Barry Douglas | Officer | +Grant | 27,363 | — | — |
| 2025-02-03 | Weber Barbara | Director,Officer | +Grant | 105,875 | — | — |
| 2025-02-03 | Crystal Adam | Officer | +Grant | 53,015 | — | — |
| 2025-02-03 | Beckman Daniella | Officer | +Grant | 26,119 | — | — |
| 2024-11-18 | Rothenberg Mace | Director | +Buy | 10,000 | $3.78 | $37,800 |
| 2024-11-14 | Rothenberg Mace | Director | +Buy | 10,000 | $3.62 | $36,200 |
| 2024-11-07 | EcoR1 Capital, LLC | TenPercentOwner | −Sell | 1,143,124 | $2.92 | $3M |
| 2024-11-07 | EcoR1 Capital, LLC | TenPercentOwner | −Sell | 62,318 | $3.29 | $205,026 |
| 2024-11-06 | Boxer Capital Management, LLC | Other | −Sell | 3,080,000 | $3.14 | $10M |
| 2024-11-06 | EcoR1 Capital, LLC | TenPercentOwner | −Sell | 1,494,558 | $3.28 | $5M |
| 2024-10-25 | Boxer Capital Management, LLC | Other | −Sell | 633,000 | $6.87 | $4M |
| 2024-10-22 | Boxer Capital Management, LLC | Other | −Sell | 250,000 | $6.78 | $2M |
| 2024-10-21 | Boxer Capital Management, LLC | Other | −Sell | 625,000 | $7.05 | $4M |
| 2024-09-13 | TRV GP IV, LLC | TenPercentOwner | −Sell | 67,400 | $10.53 | $709,722 |
| 2024-09-05 | TRV GP IV, LLC | TenPercentOwner | −Sell | 75,000 | $11.56 | $867,000 |
| 2024-08-30 | Third Rock Ventures IV, L.P. | TenPercentOwner | −Sell | 175,000 | $11.60 | $2M |
| 2024-08-27 | Third Rock Ventures IV, L.P. | TenPercentOwner | −Sell | 25,000 | $11.55 | $288,750 |
| 2024-08-19 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 150,000 | $10.09 | $2M |
| 2024-08-16 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 135,000 | $9.79 | $1M |
| 2024-08-01 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 40,000 | $9.80 | $392,000 |
| 2024-07-31 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 100,000 | $9.93 | $993,000 |
| 2024-07-30 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 95,000 | $9.80 | $931,000 |
| 2024-07-26 | TRV GP IV, LLC | TenPercentOwner | −Sell | 50,000 | $9.84 | $492,000 |
| 2024-07-25 | Third Rock Ventures IV, L.P. | TenPercentOwner | −Sell | 100,599 | $9.87 | $992,912 |
| 2024-07-24 | Third Rock Ventures IV, L.P. | TenPercentOwner | −Sell | 200,000 | $9.82 | $2M |
| 2024-07-23 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 125,000 | $9.79 | $1M |
| 2024-07-22 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 262,740 | $9.78 | $3M |
| 2024-07-18 | Third Rock Ventures IV, L.P. | TenPercentOwner | −Sell | 191,490 | $9.81 | $2M |
| 2024-07-17 | Third Rock Ventures GP IV, L.P. | TenPercentOwner | −Sell | 550,171 | $9.79 | $5M |
| 2024-07-02 | MVA Investors, LLC | Other | −Sell | 95,000 | $8.68 | $824,600 |
| 2024-07-01 | MVA Investors, LLC | Other | −Sell | 110,731 | $8.87 | $982,184 |
| 2024-06-28 | MVA Investors, LLC | Other | −Sell | 29,000 | $8.57 | $248,530 |
| 2024-06-07 | MVA Investors, LLC | Other | −Sell | 77,000 | $6.88 | $529,760 |
| 2024-06-06 | MVA Investors, LLC | Other | −Sell | 63,000 | $7.24 | $456,120 |
| 2024-06-05 | Borisy Alexis | Director | +Grant | 6,250 | — | — |
| 2024-06-05 | Ketchum John B | Director | +Grant | 4,687 | — | — |
| 2024-06-05 | Calhoun Lesley Ann | Director | +Sell | 5,000 | $7.21 | $36,050 |
| 2024-06-05 | Calhoun Lesley Ann | Director | +Grant | 6,250 | — | — |
| 2024-06-05 | Rothenberg Mace | Director | +Grant | 6,250 | — | — |
| 2024-06-05 | Peters Malte | Director | +Grant | 6,250 | — | — |
| 2024-05-03 | MVA Investors, LLC | Other | −Sell | 60,000 | $7.61 | $456,600 |
| 2024-05-02 | MVA Investors, LLC | Other | −Sell | 75,000 | $7.56 | $567,000 |
| 2024-05-01 | MVA Investors, LLC | Other | −Sell | 75,000 | $7.43 | $557,250 |
| 2024-02-20 | Third Rock Ventures IV, L.P. | TenPercentOwner | −Sell | 162,500 | $12.00 | $2M |
| 2024-02-07 | Crystal Adam | Officer | −Sell | 4,083 | $12.62 | $51,527 |
| 2024-02-07 | Beckman Daniella | Officer | −Sell | 1,817 | $12.62 | $22,931 |
| 2024-02-07 | Barry Douglas | Officer | −Sell | 1,354 | $12.62 | $17,087 |
| 2024-02-07 | Weber Barbara | Director,Officer | −Sell | 4,457 | $12.62 | $56,247 |
| 2024-02-06 | Crystal Adam | Officer | −Sell | 4,288 | $12.56 | $53,857 |
| 2024-02-06 | Beckman Daniella | Officer | −Sell | 1,908 | $12.56 | $23,964 |
| 2024-02-06 | Barry Douglas | Officer | −Sell | 1,422 | $12.56 | $17,860 |
| 2024-02-06 | Weber Barbara | Director,Officer | −Sell | 4,681 | $12.56 | $58,793 |
| 2024-02-01 | Barry Douglas | Officer | +Grant | 22,859 | — | — |
| 2024-02-01 | Weber Barbara | Director,Officer | +Grant | 87,168 | — | — |
| 2024-02-01 | Crystal Adam | Officer | +Grant | 46,599 | — | — |
| 2024-02-01 | Beckman Daniella | Officer | +Grant | 39,413 | — | — |
| 2023-11-01 | Crystal Adam | Officer | −Sell | 7,507 | $8.39 | $62,984 |
| 2023-10-16 | Boxer Asset Management Inc. | Other | +Buy | 500,000 | $6.84 | $3M |
| 2023-10-16 | Davis Aaron I. | Other | +Buy | 500,000 | $6.84 | $3M |
| 2023-10-13 | Boxer Asset Management Inc. | Other | +Buy | 750,000 | $7.07 | $5M |
| 2023-10-13 | Davis Aaron I. | Other | +Buy | 750,000 | $7.07 | $5M |
| 2023-10-09 | MVA Investors, LLC | Other | −Sell | 175,000 | $9.97 | $2M |
| 2023-10-09 | MVA Investors, LLC | Other | −Sell | 50,000 | $9.91 | $495,500 |
| 2023-08-29 | Ketchum John B | Director | +Grant | 10,000 | — | — |
| 2023-08-11 | MVA Investors, LLC | Other | +Buy | 475,000 | $5.15 | $2M |
| 2023-08-11 | Davis Aaron I. | Director,Other | +Grant | 475,000 | $5.15 | $2M |
| 2023-06-06 | Davis Aaron I. | Director | +Grant | 5,000 | — | — |
| 2023-06-06 | Peters Malte | Director | +Grant | 5,000 | — | — |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
