Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2025-12-31 | Szwarcberg Javier B. | Director,Officer | +Grant | 4,690 | $4.53 | $21,246 |
| 2025-12-15 | Szwarcberg Javier B. | Director,Officer | +Exercise | 1,196 | — | — |
| 2025-12-15 | Szwarcberg Javier B. | Director,Officer | +Exercise | 1,480 | — | — |
| 2025-12-15 | Szwarcberg Javier B. | Director,Officer | −Tax w/h | 608 | $80.67 | $49,047 |
| 2025-12-15 | Szwarcberg Javier B. | Director,Officer | −Tax w/h | 752 | $80.67 | $60,664 |
| 2025-12-15 | Gharib Samir M. | Officer | −Tax w/h | 184 | $80.67 | $14,843 |
| 2025-12-15 | Gharib Samir M. | Officer | +Exercise | 513 | — | — |
| 2025-12-15 | Gharib Samir M. | Officer | −Tax w/h | 178 | $80.67 | $14,359 |
| 2025-12-15 | Gharib Samir M. | Officer | +Exercise | 496 | — | — |
| 2025-12-11 | Szwarcberg Javier B. | Director,Officer | +Exercise | 4,950 | — | — |
| 2025-12-11 | Szwarcberg Javier B. | Director,Officer | −Tax w/h | 2,194 | $88.41 | $193,972 |
| 2025-12-11 | Gharib Samir M. | Officer | −Tax w/h | 680 | $88.41 | $60,119 |
| 2025-12-11 | Gharib Samir M. | Officer | +Exercise | 1,900 | — | — |
| 2025-12-11 | Ways Douglas Kirk | Director,Officer | +Exercise | 1,250 | — | — |
| 2025-12-10 | Szwarcberg Javier B. | Director,Officer | +Exercise | 1,196 | — | — |
| 2025-12-10 | Szwarcberg Javier B. | Director,Officer | −Tax w/h | 428 | $85.67 | $36,667 |
| 2025-12-10 | Gharib Samir M. | Officer | −Tax w/h | 184 | $85.67 | $15,763 |
| 2025-12-10 | Gharib Samir M. | Officer | +Exercise | 514 | — | — |
| 2025-10-20 | Szwarcberg Javier B. | Director,Officer | −Tax w/h | 1,539 | $148.16 | $228,018 |
| 2025-10-20 | Szwarcberg Javier B. | Director,Officer | +Exercise | 4,784 | — | — |
| 2025-10-20 | Gharib Samir M. | Officer | −Tax w/h | 661 | $148.16 | $97,934 |
| 2025-10-20 | Gharib Samir M. | Officer | +Exercise | 2,053 | — | — |
| 2025-10-06 | Parkman Healthcare Partners LLC | TenPercentOwner | +Buy | 256 | $17.91 | $4,585 |
| 2025-10-06 | Parkman Healthcare Partners LLC | TenPercentOwner | −Sell | 25 | $17.46 | $437 |
| 2025-10-06 | Parkman Healthcare Partners LLC | TenPercentOwner | −Sell | 232 | $19.33 | $4,485 |
| 2025-10-06 | Parkman Healthcare Partners LLC | TenPercentOwner | −Sell | 25 | $17.46 | $437 |
| 2025-10-06 | Parkman Healthcare Partners LLC | TenPercentOwner | +Buy | 256 | $17.91 | $4,585 |
| 2025-10-06 | Parkman Healthcare Partners LLC | TenPercentOwner | −Sell | 232 | $19.33 | $4,485 |
| 2024-12-16 | Szwarcberg Javier B. | Director,Officer | +Exercise | 89,700 | — | — |
| 2024-12-16 | Szwarcberg Javier B. | Director,Officer | −Tax w/h | 32,005 | $0.39 | $12,482 |
| 2024-12-16 | Szwarcberg Javier B. | Director,Officer | +Exercise | 111,000 | — | — |
| 2024-12-16 | Szwarcberg Javier B. | Director,Officer | −Tax w/h | 39,605 | $0.39 | $15,446 |
| 2024-12-16 | Gharib Samir M. | Officer | −Tax w/h | 13,291 | $0.39 | $5,183 |
| 2024-12-16 | Gharib Samir M. | Officer | +Exercise | 38,500 | — | — |
| 2024-12-16 | Gharib Samir M. | Officer | +Exercise | 37,250 | — | — |
| 2024-12-16 | Gharib Samir M. | Officer | −Tax w/h | 13,737 | $0.39 | $5,357 |
| 2024-12-16 | Charlton Ralph William III | Officer | +Exercise | 26,600 | — | — |
| 2024-12-16 | Charlton Ralph William III | Officer | +Exercise | 31,750 | — | — |
| 2024-12-16 | Charlton Ralph William III | Officer | −Tax w/h | 9,491 | $0.39 | $3,701 |
| 2024-12-16 | Charlton Ralph William III | Officer | −Tax w/h | 11,329 | $0.39 | $4,418 |
| 2024-12-10 | Szwarcberg Javier B. | Director,Officer | −Tax w/h | 128,020 | $0.54 | $69,131 |
| 2024-12-10 | Szwarcberg Javier B. | Director,Officer | +Exercise | 358,800 | — | — |
| 2024-12-10 | Gharib Samir M. | Officer | +Exercise | 154,000 | — | — |
| 2024-12-10 | Gharib Samir M. | Officer | −Tax w/h | 54,948 | $0.54 | $29,672 |
| 2024-12-10 | Charlton Ralph William III | Officer | +Exercise | 106,400 | — | — |
| 2024-12-10 | Charlton Ralph William III | Officer | −Tax w/h | 37,964 | $0.54 | $20,501 |
| 2024-03-21 | Novo Holdings A/S | TenPercentOwner | −Sell | 465,021 | $0.75 | $348,766 |
| 2024-03-20 | Novo Holdings A/S | TenPercentOwner | −Sell | 359,979 | $0.73 | $262,785 |
| 2024-03-19 | Novo Holdings A/S | TenPercentOwner | −Sell | 593,000 | $0.76 | $450,680 |
| 2024-03-18 | Novo Holdings A/S | TenPercentOwner | −Sell | 842,020 | $0.77 | $648,355 |
| 2024-03-14 | Novo Holdings A/S | TenPercentOwner | −Sell | 1,912,316 | $0.89 | $2M |
| 2023-12-29 | Gharib Samir M. | Officer | +Grant | 11,255 | $0.98 | $11,030 |
| 2023-12-29 | Charlton Ralph William III | Officer | +Grant | 9,361 | $0.98 | $9,174 |
| 2023-12-15 | Szwarcberg Javier B. | Director,Officer | +Exercise | 111,000 | — | — |
| 2023-12-15 | Szwarcberg Javier B. | Director,Officer | −Tax w/h | 38,384 | $1.66 | $63,717 |
| 2023-12-15 | Gharib Samir M. | Officer | −Tax w/h | 23,213 | $1.66 | $38,534 |
| 2023-12-15 | Gharib Samir M. | Officer | +Exercise | 75,000 | — | — |
| 2023-12-15 | Gharib Samir M. | Officer | +Exercise | 37,250 | — | — |
| 2023-12-15 | Gharib Samir M. | Officer | −Tax w/h | 12,882 | $1.66 | $21,384 |
| 2023-12-15 | Charlton Ralph William III | Officer | +Exercise | 31,750 | — | — |
| 2023-12-15 | Charlton Ralph William III | Officer | −Tax w/h | 10,980 | $1.66 | $18,227 |
| 2023-06-30 | Gharib Samir M. | Officer | +Grant | 10,484 | $0.98 | $10,274 |
| 2023-06-30 | Gharib Samir M. | Officer | +Exercise | 75,000 | — | — |
| 2023-06-30 | Gharib Samir M. | Officer | −Tax w/h | 25,936 | $2.15 | $55,762 |
| 2023-06-30 | Szwarcberg Javier B. | Director,Officer | +Grant | 20,000 | $0.98 | $19,600 |
| 2023-06-30 | Charlton Ralph William III | Officer | +Grant | 12,378 | $0.98 | $12,130 |
| 2023-02-16 | Novo Holdings A/S | TenPercentOwner | +Buy | 2,208,000 | $3.17 | $7M |
| 2023-02-16 | O'Donnell Niall | Director | +Buy | 630,400 | $3.17 | $2M |
| 2023-01-03 | Gharib Samir M. | Officer | −Tax w/h | 15,293 | $1.15 | $17,587 |
| 2023-01-03 | Gharib Samir M. | Officer | +Exercise | 37,500 | — | — |
| 2022-12-30 | Gharib Samir M. | Officer | +Grant | 1 | $0.93 | $1 |
| 2022-12-30 | Szwarcberg Javier B. | Director,Officer | +Grant | 14,705 | $0.93 | $13,676 |
| 2022-12-30 | Charlton Ralph William III | Officer | +Grant | 12,864 | $0.93 | $11,964 |
| 2022-06-30 | Gharib Samir M. | Officer | +Exercise | 37,500 | — | — |
| 2022-06-30 | Gharib Samir M. | Officer | +Grant | 5,446 | $1.48 | $8,060 |
| 2022-06-30 | Gharib Samir M. | Officer | −Tax w/h | 12,968 | $1.74 | $22,564 |
| 2021-12-31 | Gharib Samir M. | Officer | +Other | 2,220 | $3.79 | $8,414 |
| 2021-06-30 | Gharib Samir M. | Officer | +Other | 1,412 | $9.53 | $13,456 |
| 2021-06-30 | KING RICHARD | Director,Officer | +Other | 2,230 | $9.53 | $21,252 |
| 2021-05-20 | SIMPSON CAMILLA V | Director | +Exercise | 334 | $0.85 | $284 |
| 2021-05-20 | SIMPSON CAMILLA V | Director | −Sell | 334 | $15.29 | $5,107 |
| 2021-05-19 | Novo Holdings A/S | TenPercentOwner | −Sell | 475,000 | $13.90 | $7M |
| 2021-04-30 | SIMPSON CAMILLA V | Director | −Sell | 14,045 | $16.14 | $226,686 |
| 2021-04-30 | SIMPSON CAMILLA V | Director | +Exercise | 14,045 | $0.85 | $11,938 |
| 2020-10-14 | HANSSON JONAS | Director | +Buy | 250,000 | $15.00 | $4M |
| 2020-10-14 | HANSSON JONAS | Director | +Conversion | 1,783,621 | — | — |
| 2020-10-14 | HealthCap VIII, L.P. | Other | +Conversion | 1,783,621 | — | — |
| 2020-10-14 | HealthCap VIII, L.P. | Other | +Buy | 250,000 | $15.00 | $4M |
| 2020-10-14 | Chaya Moghrabi Dina | Director | +Buy | 250,000 | $15.00 | $4M |
| 2020-10-14 | Chaya Moghrabi Dina | Director | +Conversion | 1,911,022 | — | — |
| 2020-10-14 | Omega Fund VI GP Manager, Ltd. | TenPercentOwner | +Buy | 250,000 | $15.00 | $4M |
| 2020-10-14 | Omega Fund VI GP Manager, Ltd. | TenPercentOwner | +Conversion | 1,911,022 | — | — |
| 2020-10-14 | O'Donnell Niall | Director | +Conversion | 445,905 | — | — |
| 2020-10-14 | O'Donnell Niall | Director | +Buy | 250,000 | $15.00 | $4M |
| 2020-10-14 | Muralidhar Bali | Director | +Buy | 200,000 | $15.00 | $3M |
| 2020-10-14 | Muralidhar Bali | Director | +Conversion | 1,592,518 | — | — |
| 2020-10-14 | RiverVest Venture Fund III, L.P. | TenPercentOwner | +Conversion | 828,109 | — | — |
| 2020-10-14 | RiverVest Venture Fund III, L.P. | TenPercentOwner | +Buy | 250,000 | $15.00 | $4M |
| 2020-10-14 | RiverVest Venture Fund III, L.P. | TenPercentOwner | +Conversion | 1,070,172 | — | — |
| 2020-10-14 | Novo Holdings A/S | TenPercentOwner | +Conversion | 4,739,336 | — | — |
| 2020-10-14 | Novo Holdings A/S | TenPercentOwner | +Buy | 250,000 | $15.00 | $4M |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
