Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2025-10-27 | Mack David Henry | Director,Officer | +Exercise | 220,643 | $1.37 | $302,281 |
| 2025-10-23 | OrbiMed Capital GP V LLC | TenPercentOwner | −Sell | 1,000,000 | $1.52 | $2M |
| 2025-09-10 | ORBIMED ADVISORS LLC | TenPercentOwner | −Sell | 500,000 | $1.80 | $900,000 |
| 2025-07-01 | Mack David Henry | Director,Officer | −Sell | 58,411 | $1.06 | $61,916 |
| 2025-07-01 | Carulli Michael | Officer | −Sell | 28,249 | $1.06 | $29,944 |
| 2025-07-01 | Jalota Deepika | Officer | −Sell | 33,065 | $1.06 | $35,049 |
| 2025-07-01 | Ticktin Robert | Officer | −Sell | 23,151 | $1.06 | $24,540 |
| 2025-01-03 | Mack David Henry | Director,Officer | +Exercise | 17,709 | $0.53 | $9,386 |
| 2024-12-03 | Mack David Henry | Director,Officer | +Exercise | 91,750 | $0.53 | $48,628 |
| 2024-09-11 | Carulli Michael | Officer | −Sell | 2,891 | $1.50 | $4,337 |
| 2024-09-11 | Jalota Deepika | Officer | −Sell | 7,218 | $1.50 | $10,827 |
| 2024-01-18 | Mack David Henry | Director,Officer | +Grant | 163,890 | — | — |
| 2024-01-18 | Carulli Michael | Officer | +Grant | 82,220 | — | — |
| 2024-01-18 | Jalota Deepika | Officer | +Grant | 95,555 | — | — |
| 2023-11-22 | OrbiMed Genesis GP LLC | TenPercentOwner | −Sell | 87,786 | $2.23 | $195,763 |
| 2023-11-10 | Mack David Henry | Director,Officer | +Gift | 85,307 | — | — |
| 2023-11-10 | Mack David Henry | Director,Officer | −Gift | 85,307 | — | — |
| 2023-10-18 | Mack David Henry | Director,Officer | +Exercise | 198,407 | $0.53 | $105,156 |
| 2023-09-15 | Alland Leila | Officer | −Sell | 6,291 | $6.62 | $41,646 |
| 2023-09-15 | Jalota Deepika | Officer | −Sell | 4,104 | $6.62 | $27,168 |
| 2023-08-07 | Mack David Henry | Director,Officer | +Exercise | 85,500 | $0.53 | $45,315 |
| 2022-11-25 | Kung Winston | Officer | −Gift | 2,560 | — | — |
| 2022-09-09 | Alland Leila | Officer | +Grant | 52,200 | — | — |
| 2022-09-09 | Jalota Deepika | Officer | +Grant | 34,050 | — | — |
| 2022-05-26 | OrbiMed Capital GP V LLC | TenPercentOwner | −Sell | 26,253 | $15.93 | $418,210 |
| 2022-04-27 | Mack David Henry | Director,Officer | +Exercise | 33,000 | $0.53 | $17,490 |
| 2022-04-20 | Kung Winston | Officer | +Exercise | 4,000 | $3.22 | $12,880 |
| 2022-03-31 | OrbiMed Genesis GP LLC | TenPercentOwner | −Sell | 34,500 | $21.17 | $730,365 |
| 2022-03-30 | OrbiMed Genesis GP LLC | TenPercentOwner | −Sell | 75,000 | $22.39 | $2M |
| 2022-03-29 | OrbiMed Genesis GP LLC | TenPercentOwner | −Sell | 365,000 | $21.52 | $8M |
| 2022-03-08 | Mack David Henry | Director,Officer | +Exercise | 20,000 | $1.37 | $27,400 |
| 2021-12-30 | Kung Winston | Officer | −Gift | 2,725 | — | — |
| 2021-12-15 | Mack David Henry | Director,Officer | +Exercise | 9,000 | $0.53 | $4,770 |
| 2021-12-09 | Mack David Henry | Director,Officer | −Gift | 40,000 | — | — |
| 2021-12-09 | Mack David Henry | Director,Officer | +Gift | 40,000 | — | — |
| 2021-10-06 | Schroeder Thilo | Director | −Sell | 800 | $30.15 | $24,120 |
| 2021-10-04 | Schroeder Thilo | Director | −Sell | 100 | $30.08 | $3,008 |
| 2021-10-01 | Schroeder Thilo | Director | −Sell | 11,541 | $30.10 | $347,384 |
| 2021-09-30 | Schroeder Thilo | Director | −Sell | 2,978 | $30.03 | $89,429 |
| 2021-09-29 | Schroeder Thilo | Director | −Sell | 5,708 | $30.04 | $171,468 |
| 2021-09-27 | Schroeder Thilo | Director | −Sell | 1,753 | $30.11 | $52,783 |
| 2021-09-22 | LEVINE ARNOLD J | Director | −Sell | 3,500 | $30.00 | $105,000 |
| 2021-09-22 | Schroeder Thilo | Director | −Sell | 100 | $30.00 | $3,000 |
| 2021-09-17 | Schroeder Thilo | Director | −Sell | 711 | $30.03 | $21,351 |
| 2021-09-13 | Schroeder Thilo | Director | −Sell | 13,272 | $30.20 | $400,814 |
| 2021-09-10 | Schroeder Thilo | Director | −Sell | 38,056 | $30.44 | $1M |
| 2021-09-10 | Schroeder Thilo | Director | −Sell | 5,171 | $31.03 | $160,456 |
| 2021-09-09 | Alland Leila | Officer | +Exercise | 100 | $3.90 | $390 |
| 2021-09-09 | Alland Leila | Officer | −Sell | 100 | $30.25 | $3,025 |
| 2021-09-09 | Schroeder Thilo | Director | −Sell | 14,329 | $30.31 | $434,312 |
| 2021-09-07 | Alland Leila | Officer | +Exercise | 3,900 | $3.90 | $15,210 |
| 2021-09-07 | Alland Leila | Officer | −Sell | 3,900 | $30.25 | $117,975 |
| 2021-09-02 | Schroeder Thilo | Director | −Sell | 5,400 | $30.15 | $162,810 |
| 2021-09-01 | Schroeder Thilo | Director | −Sell | 21,986 | $30.38 | $667,935 |
| 2021-08-31 | Schroeder Thilo | Director | −Sell | 19,520 | $30.12 | $587,942 |
| 2021-08-30 | Schroeder Thilo | Director | −Sell | 13,233 | $30.05 | $397,652 |
| 2021-08-27 | Schroeder Thilo | Director | −Sell | 1,045 | $31.06 | $32,458 |
| 2021-08-27 | Schroeder Thilo | Director | −Sell | 23,397 | $30.50 | $713,609 |
| 2021-08-26 | Schroeder Thilo | Director | −Sell | 6,091 | $31.13 | $189,613 |
| 2021-08-26 | Schroeder Thilo | Director | −Sell | 15,063 | $30.39 | $457,765 |
| 2021-08-25 | Schroeder Thilo | Director | −Sell | 13,526 | $31.01 | $419,441 |
| 2021-08-24 | Schroeder Thilo | Director | −Sell | 14,490 | $31.08 | $450,349 |
| 2021-08-23 | LEVINE ARNOLD J | Director | −Sell | 3,500 | $29.50 | $103,250 |
| 2021-08-23 | Schroeder Thilo | Director | −Sell | 700 | $31.06 | $21,742 |
| 2021-08-23 | Schroeder Thilo | Director | −Sell | 23,138 | $30.66 | $709,411 |
| 2021-08-19 | Kung Winston | Officer | +Exercise | 5,000 | $3.22 | $16,100 |
| 2021-08-19 | Mack David Henry | Director,Officer | +Exercise | 5,500 | $0.53 | $2,915 |
| 2021-08-19 | Schroeder Thilo | Director | −Sell | 3,800 | $30.97 | $117,686 |
| 2021-08-18 | Schroeder Thilo | Director | −Sell | 13,196 | $33.84 | $446,553 |
| 2021-08-18 | Schroeder Thilo | Director | −Sell | 2,237 | $34.32 | $76,774 |
| 2021-08-18 | Schroeder Thilo | Director | −Sell | 11,431 | $32.57 | $372,308 |
| 2021-08-17 | Schroeder Thilo | Director | −Sell | 15,276 | $33.21 | $507,316 |
| 2021-08-17 | Schroeder Thilo | Director | −Sell | 15,746 | $33.93 | $534,262 |
| 2021-08-17 | Jalota Deepika | Officer | −Sell | 2,896 | $33.78 | $97,827 |
| 2021-08-17 | Jalota Deepika | Officer | +Exercise | 2,896 | $3.53 | $10,223 |
| 2021-08-16 | Schroeder Thilo | Director | −Sell | 2,599 | $34.54 | $89,769 |
| 2021-08-16 | Schroeder Thilo | Director | −Sell | 19,584 | $33.80 | $661,939 |
| 2021-08-13 | Schroeder Thilo | Director | −Sell | 25,786 | $34.22 | $882,397 |
| 2021-08-13 | Schroeder Thilo | Director | −Sell | 1,500 | $34.66 | $51,990 |
| 2021-08-12 | Schroeder Thilo | Director | −Sell | 11,565 | $34.35 | $397,258 |
| 2021-08-12 | Schroeder Thilo | Director | −Sell | 1,971 | $34.83 | $68,650 |
| 2021-08-11 | Schroeder Thilo | Director | −Sell | 34,439 | $34.04 | $1M |
| 2021-08-10 | Schroeder Thilo | Director | −Sell | 17,905 | $34.76 | $622,378 |
| 2021-08-10 | Schroeder Thilo | Director | −Sell | 2,600 | $35.54 | $92,404 |
| 2021-08-09 | Schroeder Thilo | Director | −Sell | 300 | $36.64 | $10,992 |
| 2021-08-09 | Schroeder Thilo | Director | −Sell | 13,259 | $35.14 | $465,921 |
| 2021-08-09 | Schroeder Thilo | Director | −Sell | 8,623 | $36.08 | $311,118 |
| 2021-08-09 | Alland Leila | Officer | +Exercise | 4,000 | $3.90 | $15,600 |
| 2021-08-09 | Alland Leila | Officer | −Sell | 224 | $36.69 | $8,219 |
| 2021-08-09 | Alland Leila | Officer | −Sell | 2,049 | $32.66 | $66,920 |
| 2021-08-09 | Alland Leila | Officer | −Sell | 2,198 | $35.06 | $77,062 |
| 2021-08-06 | Schroeder Thilo | Director | −Sell | 19,700 | $36.61 | $721,217 |
| 2021-08-06 | Schroeder Thilo | Director | −Sell | 200 | $36.94 | $7,388 |
| 2021-08-05 | Schroeder Thilo | Director | −Sell | 26,871 | $36.38 | $977,567 |
| 2021-08-05 | Schroeder Thilo | Director | −Sell | 8,740 | $36.70 | $320,758 |
| 2021-08-04 | Schroeder Thilo | Director | −Sell | 1,760 | $34.21 | $60,210 |
| 2021-08-04 | Schroeder Thilo | Director | −Sell | 28,676 | $36.22 | $1M |
| 2021-08-04 | Schroeder Thilo | Director | −Sell | 17,175 | $35.10 | $602,843 |
| 2021-08-04 | Schroeder Thilo | Director | −Sell | 5,249 | $36.80 | $193,163 |
| 2021-08-03 | Kung Winston | Officer | −Sell | 4,500 | $33.82 | $152,190 |
| 2021-08-03 | Kung Winston | Officer | +Exercise | 4,500 | $3.22 | $14,490 |
| 2021-08-03 | Schroeder Thilo | Director | −Sell | 100 | $34.74 | $3,474 |
| 2021-08-03 | Schroeder Thilo | Director | −Sell | 30,145 | $33.80 | $1M |
| 2021-08-02 | Schroeder Thilo | Director | −Sell | 13,031 | $34.74 | $452,697 |
| 2021-07-29 | Schroeder Thilo | Director | −Sell | 2,300 | $35.73 | $82,179 |
| 2021-07-28 | Schroeder Thilo | Director | −Sell | 8,724 | $35.76 | $311,970 |
| 2021-07-27 | Schroeder Thilo | Director | −Sell | 535 | $35.61 | $19,051 |
| 2021-07-26 | Schroeder Thilo | Director | −Sell | 4,839 | $35.73 | $172,897 |
| 2021-07-23 | Schroeder Thilo | Director | −Sell | 11,988 | $36.00 | $431,568 |
| 2021-07-22 | Schroeder Thilo | Director | −Sell | 200 | $35.61 | $7,122 |
| 2021-07-21 | Mack David Henry | Director,Officer | +Exercise | 26,767 | $0.53 | $14,187 |
| 2021-07-21 | Mack David Henry | Director,Officer | −Sell | 26,767 | $35.76 | $957,188 |
| 2021-07-21 | Schroeder Thilo | Director | −Sell | 18,672 | $35.82 | $668,831 |
| 2021-07-20 | Mack David Henry | Director,Officer | +Exercise | 1,029 | $0.53 | $545 |
| 2021-07-20 | Mack David Henry | Director,Officer | −Sell | 1,029 | $35.53 | $36,560 |
| 2021-07-20 | LEVINE ARNOLD J | Director | −Sell | 3,500 | $35.12 | $122,920 |
| 2021-07-13 | Kliman Gilbert H | TenPercentOwner | −Other | 500,000 | — | — |
| 2021-07-13 | Kliman Gilbert H | TenPercentOwner | +Other | 22,148 | — | — |
| 2021-07-13 | Kliman Gilbert H | TenPercentOwner | +Other | 2,441 | — | — |
| 2021-07-13 | Kliman Gilbert H | TenPercentOwner | +Other | 3,642 | — | — |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
