Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-05-21 | Kasraian Kasra | Officer | −Sell | 1,233 | $1.41 | $1,739 |
| 2026-03-04 | McArthur James G | Director,Officer | −Sell | 5,144 | $6.23 | $32,047 |
| 2026-03-04 | McArthur James G | Director,Officer | −Sell | 131 | $6.33 | $829 |
| 2026-03-04 | Donnelly Noel | Officer | −Sell | 52 | $6.33 | $329 |
| 2026-03-04 | Donnelly Noel | Officer | −Sell | 2,032 | $6.23 | $12,659 |
| 2026-03-04 | STRECK PAUL | Officer | −Sell | 47 | $6.29 | $296 |
| 2026-03-04 | STRECK PAUL | Officer | −Sell | 1,832 | $6.23 | $11,413 |
| 2026-03-01 | McArthur James G | Director,Officer | +Grant | 187,688 | — | — |
| 2026-03-01 | Donnelly Noel | Officer | +Grant | 76,793 | — | — |
| 2026-03-01 | STRECK PAUL | Officer | +Grant | 50,300 | — | — |
| 2026-03-01 | Kasraian Kasra | Officer | +Grant | 34,557 | — | — |
| 2026-03-01 | Vittiglio Joseph | Officer | +Grant | 30,717 | — | — |
| 2025-12-08 | Vittiglio Joseph | Officer | +Grant | 35,000 | — | — |
| 2025-09-30 | Oxford Science Enterprises plc | Other | +Buy | 200,000 | $3.20 | $640,000 |
| 2025-09-26 | RA Capital Healthcare Fund LP | Director,TenPercentOwner | +Buy | 9,375,000 | $3.20 | $30M |
| 2025-05-30 | STRECK PAUL | Officer | +Buy | 8,375 | $1.24 | $10,385 |
| 2025-05-20 | Kasraian Kasra | Officer | +Grant | 16,750 | — | — |
| 2025-04-17 | McArthur James G | Director,Officer | +Buy | 10,000 | $1.36 | $13,600 |
| 2025-04-08 | McArthur James G | Director,Officer | +Buy | 41,500 | $1.15 | $47,725 |
| 2025-03-03 | McArthur James G | Director,Officer | +Grant | 60,719 | — | — |
| 2025-03-03 | STRECK PAUL | Officer | +Grant | 19,430 | — | — |
| 2025-03-03 | Donnelly Noel | Officer | +Grant | 23,283 | — | — |
| 2025-03-03 | DeLena Mary Beth | Officer | +Grant | 13,400 | — | — |
| 2025-02-26 | Donnelly Noel | Officer | −Sell | 1,527 | $1.68 | $2,565 |
| 2025-02-26 | DeLena Mary Beth | Officer | −Sell | 1,432 | $1.68 | $2,406 |
| 2025-02-24 | Donnelly Noel | Officer | +Grant | 3,200 | — | — |
| 2025-02-24 | DeLena Mary Beth | Officer | +Grant | 3,000 | — | — |
| 2024-07-25 | Mellion Michelle L | Officer | −Sell | 7,571 | $18.06 | $136,732 |
| 2024-07-25 | Mellion Michelle L | Officer | +Exercise | 7,571 | $10.21 | $77,300 |
| 2024-07-24 | Mellion Michelle L | Officer | −Sell | 201 | $18.01 | $3,620 |
| 2024-07-24 | Mellion Michelle L | Officer | +Exercise | 201 | $10.21 | $2,052 |
| 2024-07-18 | Mellion Michelle L | Officer | +Exercise | 12,625 | $10.21 | $128,901 |
| 2024-07-18 | Mellion Michelle L | Officer | −Sell | 12,625 | $18.20 | $229,775 |
| 2024-07-16 | Mellion Michelle L | Officer | −Sell | 5,901 | $18.00 | $106,218 |
| 2024-07-16 | Mellion Michelle L | Officer | +Exercise | 5,901 | $10.21 | $60,249 |
| 2024-07-12 | Mellion Michelle L | Officer | −Sell | 3,288 | $18.04 | $59,316 |
| 2024-07-12 | Mellion Michelle L | Officer | +Exercise | 3,288 | $10.21 | $33,570 |
| 2024-07-02 | Mellion Michelle L | Officer | +Exercise | 37 | $10.21 | $378 |
| 2024-07-02 | Mellion Michelle L | Officer | −Sell | 37 | $18.07 | $669 |
| 2024-07-01 | Mellion Michelle L | Officer | +Exercise | 875 | $10.21 | $8,934 |
| 2024-07-01 | Mellion Michelle L | Officer | −Sell | 875 | $18.01 | $15,759 |
| 2024-06-24 | Mellion Michelle L | Officer | +Exercise | 9,260 | $10.21 | $94,545 |
| 2024-06-24 | Mellion Michelle L | Officer | −Sell | 9,260 | $18.19 | $168,439 |
| 2024-06-12 | Mellion Michelle L | Officer | +Exercise | 1,086 | $10.21 | $11,088 |
| 2024-06-12 | Mellion Michelle L | Officer | −Sell | 1,086 | $18.06 | $19,613 |
| 2024-06-11 | Mellion Michelle L | Officer | +Exercise | 500 | $10.21 | $5,105 |
| 2024-06-11 | Mellion Michelle L | Officer | −Sell | 500 | $18.04 | $9,020 |
| 2024-06-06 | Mellion Michelle L | Officer | −Sell | 1,411 | $18.00 | $25,398 |
| 2024-06-06 | Mellion Michelle L | Officer | +Exercise | 1,411 | $10.21 | $14,406 |
| 2024-06-05 | Mellion Michelle L | Officer | +Exercise | 7,245 | $10.21 | $73,971 |
| 2024-06-05 | Mellion Michelle L | Officer | −Sell | 7,245 | $18.09 | $131,062 |
| 2024-05-17 | Svenstrup Niels | Officer | −Sell | 10,000 | $13.41 | $134,100 |
| 2024-02-09 | Kolchinsky Peter | Director,TenPercentOwner | +Buy | 2,557,593 | $10.64 | $27M |
| 2023-11-30 | McArthur James G | Director,Officer | +Buy | 1,694 | $4.17 | $7,064 |
| 2023-06-08 | McArthur James G | Director,Officer | −Sell | 2,381 | $16.04 | $38,191 |
| 2023-06-08 | McArthur James G | Director,Officer | +Exercise | 2,381 | $2.71 | $6,453 |
| 2023-06-07 | McArthur James G | Director,Officer | −Sell | 8,419 | $16.23 | $136,640 |
| 2023-06-07 | McArthur James G | Director,Officer | +Exercise | 8,419 | $2.71 | $22,815 |
| 2023-06-06 | McArthur James G | Director,Officer | −Sell | 18,150 | $16.18 | $293,667 |
| 2023-06-06 | McArthur James G | Director,Officer | +Exercise | 18,150 | $2.71 | $49,187 |
| 2023-06-05 | McArthur James G | Director,Officer | +Exercise | 500 | $2.71 | $1,355 |
| 2023-06-05 | McArthur James G | Director,Officer | −Sell | 500 | $16.06 | $8,030 |
| 2023-06-02 | McArthur James G | Director,Officer | −Sell | 1,800 | $16.04 | $28,872 |
| 2023-06-02 | McArthur James G | Director,Officer | +Exercise | 1,800 | $2.71 | $4,878 |
| 2023-03-24 | Goyal Jaya | Officer | −Sell | 392 | $20.00 | $7,840 |
| 2023-03-24 | Goyal Jaya | Officer | +Exercise | 392 | $10.88 | $4,265 |
| 2023-02-08 | Goyal Jaya | Officer | +Exercise | 644 | $10.88 | $7,007 |
| 2023-02-08 | Goyal Jaya | Officer | −Sell | 644 | $17.00 | $10,948 |
| 2023-02-07 | Goyal Jaya | Officer | +Exercise | 3,679 | $10.88 | $40,028 |
| 2023-02-07 | Goyal Jaya | Officer | −Sell | 3,679 | $17.18 | $63,205 |
| 2023-02-06 | Goyal Jaya | Officer | −Sell | 1,677 | $17.04 | $28,576 |
| 2023-02-06 | Goyal Jaya | Officer | +Exercise | 1,677 | $10.88 | $18,246 |
| 2022-12-19 | Svenstrup Niels | Officer | +Exercise | 10,000 | $2.71 | $27,100 |
| 2022-05-10 | Deerfield Private Design Fund V, L.P. | TenPercentOwnerOther | +Buy | 208,333 | $12.00 | $2M |
| 2022-05-10 | Deerfield Private Design Fund V, L.P. | TenPercentOwnerOther | +Buy | 208,333 | $12.00 | $2M |
| 2022-05-10 | Deerfield Private Design Fund V, L.P. | TenPercentOwnerOther | +Conversion | 268,480 | — | — |
| 2022-05-10 | Deerfield Private Design Fund V, L.P. | TenPercentOwnerOther | +Conversion | 268,480 | — | — |
| 2022-05-10 | Oxford Science Enterprises plc | TenPercentOwner | +Conversion | 945,859 | — | — |
| 2022-05-10 | Oxford Science Enterprises plc | TenPercentOwner | +Conversion | 1,547,713 | — | — |
| 2022-05-10 | Oxford Science Enterprises plc | TenPercentOwner | +Conversion | 1,262,986 | — | — |
| 2022-05-10 | Kolchinsky Peter | Director,TenPercentOwner | +Conversion | 3,642,229 | — | — |
| 2022-05-10 | Kolchinsky Peter | Director,TenPercentOwner | +Buy | 249,749 | $12.00 | $3M |
| 2022-05-10 | Kolchinsky Peter | Director,TenPercentOwner | +Conversion | 207,672 | — | — |
| 2022-05-10 | Kolchinsky Peter | Director,TenPercentOwner | +Conversion | 1,052,851 | — | — |
| 2022-05-10 | Kolchinsky Peter | Director,TenPercentOwner | +Buy | 2,979,451 | $12.00 | $36M |
| 2022-05-10 | Oxford Science Enterprises plc | TenPercentOwner | +Buy | 879,970 | $12.00 | $11M |
| 2022-05-06 | KEATING LAURIE | Director | +Buy | 4,166 | $12.00 | $49,992 |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
