Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-06-22 | Bodenstedt Matthias | Officer | −Sell | 39,120 | $22.04 | $862,205 |
| 2026-06-18 | Bodenstedt Matthias | Officer | −Sell | 2,794 | $19.60 | $54,762 |
| 2026-06-17 | Reich Kristian | Officer | −Sell | 50,000 | $19.43 | $971,500 |
| 2026-06-17 | Bodenstedt Matthias | Officer | −Sell | 15,082 | $19.68 | $296,814 |
| 2026-06-16 | Reich Kristian | Officer | −Sell | 50,000 | $18.70 | $935,000 |
| 2026-06-15 | Reich Kristian | Officer | −Sell | 50,000 | $18.89 | $944,500 |
| 2026-05-11 | Bodenstedt Matthias | Officer | −Sell | 13,653 | $20.02 | $273,333 |
| 2026-04-14 | Bodenstedt Matthias | Officer | −Sell | 2,426 | $19.56 | $47,453 |
| 2026-04-13 | Santos da Silva Jorge | Director,Officer | −Sell | 51,873 | $18.23 | $945,645 |
| 2026-04-10 | Bodenstedt Matthias | Officer | −Sell | 1,925 | $19.51 | $37,557 |
| 2026-04-10 | Santos da Silva Jorge | Director,Officer | −Sell | 98,127 | $18.41 | $2M |
| 2026-04-09 | Bodenstedt Matthias | Officer | −Sell | 85,870 | $18.94 | $2M |
| 2026-03-31 | LAMPERT MARK N | Director,TenPercentOwner | −Sell | 248,530 | $16.79 | $4M |
| 2026-03-31 | LAMPERT MARK N | Director,TenPercentOwner | −Sell | 1,569,116 | $16.79 | $26M |
| 2026-03-31 | LAMPERT MARK N | Director,TenPercentOwner | −Sell | 1,932,354 | $16.79 | $32M |
| 2026-01-07 | Bodenstedt Matthias | Officer | +Grant | 354,296 | — | — |
| 2025-12-19 | Santos da Silva Jorge | Director,Officer | +Conversion | 196,316 | — | — |
| 2025-12-19 | Santos da Silva Jorge | Director,Officer | −Disp→issuer | 196,316 | — | — |
| 2025-12-19 | Reich Kristian | Officer | +Conversion | 35,389 | — | — |
| 2025-12-19 | Reich Kristian | Officer | −Disp→issuer | 35,389 | — | — |
| 2025-12-19 | Bodenstedt Matthias | Officer | −Disp→issuer | 294,473 | — | — |
| 2025-12-19 | Bodenstedt Matthias | Officer | +Conversion | 294,473 | — | — |
| 2025-12-09 | Reich Kristian | Officer | −Sell | 72,908 | $14.43 | $1M |
| 2025-12-09 | Santos da Silva Jorge | Director,Officer | −Sell | 70,000 | $14.49 | $1M |
| 2025-12-08 | Reich Kristian | Officer | −Sell | 130,000 | $15.08 | $2M |
| 2025-12-08 | Santos da Silva Jorge | Director,Officer | −Sell | 130,000 | $15.08 | $2M |
| 2025-10-08 | Bodenstedt Matthias | Officer | +Buy | 10,870 | $9.09 | $98,808 |
| 2025-09-30 | Cormorant Global Healthcare Master Fund, LP | Other | −Sell | 5,827 | $6.96 | $40,556 |
| 2025-09-29 | Cormorant Global Healthcare Master Fund, LP | Other | −Sell | 2,800,000 | $6.61 | $19M |
| 2025-09-29 | Cormorant Global Healthcare Master Fund, LP | Other | −Sell | 3,390,943 | $7.58 | $26M |
| 2025-09-29 | Cormorant Global Healthcare Master Fund, LP | Other | −Sell | 70,748 | $9.38 | $663,616 |
| 2025-09-29 | Cormorant Global Healthcare Master Fund, LP | Other | −Sell | 232,460 | $8.40 | $2M |
| 2025-09-02 | Reich Kristian | Officer | +Conversion | 48,978 | — | — |
| 2025-09-02 | Reich Kristian | Officer | −Disp→issuer | 48,978 | — | — |
| 2025-07-03 | Moukheibir Catherine | Director | +Exercise | 23,500 | — | — |
| 2025-07-03 | Moukheibir Catherine | Director | −Sell | 23,500 | $48.79 | $1M |
| 2025-02-27 | Bodenstedt Matthias | Officer | +Grant | 95,763 | — | — |
| 2025-02-27 | Santos da Silva Jorge | Director,Officer | +Grant | 95,763 | — | — |
| 2025-01-20 | Reich Kristian | Officer | +Conversion | 111,949 | — | — |
| 2025-01-20 | Reich Kristian | Officer | −Disp→issuer | 111,949 | — | — |
| 2024-10-04 | Sturge Simon | Director | −Sell | 171,000 | $53.72 | $9M |
| 2024-10-04 | BVF I GP LLC | Director,TenPercentOwner | −Sell | 1,030,589 | $50.00 | $52M |
| 2024-10-04 | BVF I GP LLC | Director,TenPercentOwner | −Sell | 132,549 | $50.00 | $7M |
| 2024-10-04 | BVF I GP LLC | Director,TenPercentOwner | −Sell | 836,862 | $50.00 | $42M |
| 2024-02-29 | Santos da Silva Jorge | Director,Officer | −Sell | 4,740 | $55.89 | $264,919 |
| 2024-02-28 | Reich Kristian | Officer | −Sell | 31,910 | $55.00 | $2M |
| 2024-02-28 | Reich Kristian | Officer | −Sell | 28,090 | $55.00 | $2M |
| 2024-02-28 | Santos da Silva Jorge | Director,Officer | −Sell | 56,065 | $55.00 | $3M |
| 2024-02-27 | Reich Kristian | Officer | −Sell | 29,431 | $55.00 | $2M |
| 2024-02-27 | Reich Kristian | Officer | −Sell | 29,491 | $55.00 | $2M |
| 2024-02-27 | Santos da Silva Jorge | Director,Officer | −Sell | 62,810 | $55.00 | $3M |
| 2024-02-21 | Reich Kristian | Officer | −Sell | 569 | $55.30 | $31,466 |
| 2024-02-21 | Reich Kristian | Officer | −Sell | 509 | $55.31 | $28,153 |
| 2024-02-21 | Santos da Silva Jorge | Director,Officer | −Sell | 1,125 | $55.27 | $62,179 |
| 2024-02-20 | Santos da Silva Jorge | Director,Officer | −Sell | 20,000 | $57.44 | $1M |
| 2024-02-20 | Reich Kristian | Officer | −Sell | 10,000 | $57.43 | $574,300 |
| 2024-02-20 | Reich Kristian | Officer | −Sell | 10,000 | $57.45 | $574,500 |
| 2024-02-16 | Reich Kristian | Officer | −Sell | 10,000 | $60.15 | $601,500 |
| 2024-02-16 | Reich Kristian | Officer | −Sell | 10,000 | $60.15 | $601,500 |
| 2024-02-16 | Santos da Silva Jorge | Director,Officer | −Sell | 20,000 | $60.15 | $1M |
| 2024-02-15 | Reich Kristian | Officer | −Sell | 10,000 | $60.16 | $601,600 |
| 2024-02-15 | Reich Kristian | Officer | −Sell | 10,000 | $60.17 | $601,700 |
| 2024-02-15 | Santos da Silva Jorge | Director,Officer | −Sell | 20,000 | $60.18 | $1M |
| 2024-02-14 | Reich Kristian | Officer | −Sell | 10,000 | $62.42 | $624,200 |
| 2024-02-14 | Reich Kristian | Officer | −Sell | 10,000 | $62.43 | $624,300 |
| 2023-12-20 | Bodenstedt Matthias | Officer | −Sell | 5,264 | $58.34 | $307,102 |
| 2023-12-19 | Bodenstedt Matthias | Officer | −Sell | 94,736 | $59.22 | $6M |
| 2023-10-05 | Cormorant Private Healthcare Fund II, LP | TenPercentOwner | +Buy | 58,839 | $59.90 | $4M |
| 2023-10-04 | Cormorant Private Healthcare Fund IV LP | TenPercentOwner | +Buy | 67,814 | $57.32 | $4M |
| 2023-10-03 | Cormorant Private Healthcare Fund IV LP | TenPercentOwner | +Buy | 150,487 | $57.25 | $9M |
| 2023-10-02 | Cormorant Private Healthcare Fund IV LP | TenPercentOwner | +Buy | 74,911 | $57.37 | $4M |
| 2023-10-01 | Reich Kristian | Officer | +Conversion | 2,527,477 | — | — |
| 2023-10-01 | Reich Kristian | Officer | +Conversion | 41,981 | — | — |
| 2023-10-01 | Reich Kristian | Officer | −Disp→issuer | 41,981 | — | — |
| 2023-10-01 | Reich Kristian | Officer | −Disp→issuer | 2,527,477 | — | — |
| 2023-10-01 | Santos da Silva Jorge | Director,Officer | −Disp→issuer | 140,071 | — | — |
| 2023-10-01 | Santos da Silva Jorge | Director,Officer | +Conversion | 3,027,483 | — | — |
| 2023-10-01 | Santos da Silva Jorge | Director,Officer | −Disp→issuer | 3,027,483 | — | — |
| 2023-10-01 | Santos da Silva Jorge | Director,Officer | +Conversion | 140,071 | — | — |
| 2023-10-01 | Bodenstedt Matthias | Officer | +Conversion | 62,972 | — | — |
| 2023-10-01 | Bodenstedt Matthias | Officer | −Disp→issuer | 62,972 | — | — |
| 2023-10-01 | Sturge Simon | Director | +Conversion | 342,980 | — | — |
| 2023-10-01 | Sturge Simon | Director | −Disp→issuer | 342,980 | — | — |
| 2023-06-30 | Chen Bihua | TenPercentOwner | +Buy | 800,000 | $50.00 | $40M |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 21,823 | $53.98 | $1M |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 4,725 | $52.81 | $249,527 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 8,697 | $52.01 | $452,331 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 17,662 | $50.77 | $896,700 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 59,787 | $49.82 | $3M |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 37,783 | $48.93 | $2M |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 10,946 | $44.93 | $491,804 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 31,558 | $44.23 | $1M |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 66,087 | $43.30 | $3M |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 61,042 | $42.12 | $3M |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 50,642 | $41.03 | $2M |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 38,623 | $39.87 | $2M |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 10,593 | $39.17 | $414,928 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 3,755 | $38.18 | $143,366 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 1,481 | $36.91 | $54,664 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 85 | $72.46 | $6,159 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 15 | $70.62 | $1,059 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 16 | $65.32 | $1,045 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 95 | $64.44 | $6,122 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 139 | $63.85 | $8,875 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 136 | $62.20 | $8,459 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 417 | $60.21 | $25,108 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 1,302 | $58.98 | $76,792 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 295 | $57.63 | $17,001 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 1,894 | $56.89 | $107,750 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 1,453 | $55.83 | $81,121 |
| 2023-06-26 | Chen Bihua | TenPercentOwner | +Buy | 18,949 | $54.92 | $1M |
| 2023-04-05 | Reich Kristian | Officer | −Disp→issuer | 500,006 | — | — |
| 2023-04-05 | Reich Kristian | Officer | +Conversion | 500,006 | — | — |
| 2023-04-05 | Reich Kristian | Officer | +Conversion | 98,090 | — | — |
| 2023-04-05 | Reich Kristian | Officer | −Disp→issuer | 98,090 | — | — |
| 2023-04-05 | Bodenstedt Matthias | Officer | +Conversion | 147,135 | — | — |
| 2023-04-05 | Bodenstedt Matthias | Officer | −Disp→issuer | 147,135 | — | — |
| 2023-04-05 | Bodenstedt Matthias | Officer | +Conversion | 410,796 | — | — |
| 2023-04-05 | Bodenstedt Matthias | Officer | −Disp→issuer | 410,796 | — | — |
| 2023-03-21 | Chen Bihua | TenPercentOwner | +Buy | 238,511 | $21.70 | $5M |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
