Health Care · Pharmaceutical Preparations · Nasdaq · CIK 1503802 · FYE Dec 31 · Prices AT CLOSE 2026-08-19 (USD) Last $2.00 · Day +3.63% · Mkt cap $44M · 1Y −67.8% · Off 52W high −81.8% · Vol (1Y) 115.2% Price2023-08-21 → 2026-08-19 KPTI close: $23.6 on 2023-08-21 to $2.0 on 2026-08-19. Split-adj closes · 240 of 3,212 · price returnⓘ At a glance | Short interest33.3% of sh out | | Days to cover2.7d | | 13F net flow (QoQ)+15.40% | | Top-10 13F concentration66.0% | | Next report (est.)2026-11-12 |
SI 2026-07-31 · 13F 2026-Q1ⓘ Key fundamentalsFY 2025 | Sales (TTM)$146.6M | | Earnings (TTM)-$224.7M | | Net margin−134.2% | | Sales growth 3Y−2.4% |
FY ratios · TTM sales/earnings (USD)ⓘ Trailing returns | YTD−72.8% | | 1Y−67.8% | | 3Y−91.5% | | 5Y−97.0% | | 10Y−98.3% | | Since incept. (ann.)−31.2% |
Total return · from 2013-11-06ⓘ Risk | Ann. volatility (1Y)115.2% | | Ann. volatility (3Y)104.9% | | Sharpe (1Y)−0.06 | | Sharpe (3Y)−0.20 | | Max drawdown (1Y)−83.0% | | Max drawdown (3Y)−92.7% | | Beta (3Y vs SPY)2.34 |
Daily returns, ann.ⓘ Top institutional holders13F 2026-Q1 | Manager | Shares | Value | % sh out | QoQ |
|---|
| Commodore Capital LP | 1.9M | $11M | 10.63% | new | | RA CAPITAL MANAGEMENT, L.P. | 1.9M | $11M | 10.45% | new | | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.8M | $10M | 9.85% | +328.7% | | T. Rowe Price Investment Management, Inc. | 1.5M | $9M | 8.41% | −25.8% | | Avidity Partners Management LP | 927,482 | $6M | 5.06% | +589.2% | | GOLDMAN SACHS GROUP INC | 947,579 | $5M | 5.17% | new | | Catalio Capital Management, LP | 897,709 | $5M | 4.89% | +527.8% | | VANGUARD CAPITAL MANAGEMENT LLC | 739,745 | $4M | 4.03% | new |
Δ vs 2025-Q4ⓘ Latest reported quarterslast report 2026-08-13 | Period end | Reported | EPS | EPS YoY | Revenue | Rev YoY |
|---|
| 2026-06-30 | 2026-08-13 | −$2.32 | — | $33.4M | −11.9% | | 2026-03-31 | 2026-05-14 | −$1.24 | — | $35.1M | +16.8% | | 2025-12-31 | 2026-02-12 | — | — | $34.1M | +11.6% | | 2025-09-30 | 2025-11-03 | −$3.82 | — | $44.0M | +13.6% |
As-reported XBRL · next 2026-11-12 est.ⓘ Segment mixFY2025 (ended Dec 2025) Product 79% · License And Other 21% product & service · TAGGED revenueⓘ Basis & disclosures - EOD closes · nothing imputed or averaged · absent “—”
- As-of differs by block · 13F = US long, 45+d lag, LOWER bound
- Not investment advice · no recommendation, price target or solicitation
- EDGAR + foreign registers · marketstack (licensed EOD) · spzco.com/methodology
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