Health Care · Pharmaceutical Preparations · Nasdaq · CIK 1888886 · FYE Dec 31 · Prices AT CLOSE 2026-08-19 (USD) Last $54.13 · Day +1.12% · Mkt cap $11.5B · 1Y +187.9% · Off 52W high −43.0% · Vol (1Y) 120.3% Price2023-08-21 → 2026-08-19 GPCR close: $29.0 on 2023-08-21 to $54.1 on 2026-08-19. Split-adj closes · 240 of 883 · price returnⓘ At a glance | Short interest2.8% of sh out | | Days to cover11.4d | | 13F net flow (QoQ)+0.74% | | Top-10 13F concentration64.0% | | Next report (est.)2026-11-05 |
SI 2026-07-31 · 13F 2026-Q1ⓘ Key fundamentalsFY 2025 | Earnings (TTM)-$214.8M | | ROE−11.9% | | ROIC−541.6% |
FY ratios · TTM sales/earnings (USD)ⓘ Trailing returns | YTD−22.2% | | 1Y+187.9% | | 3Y+86.6% | | Since incept. (ann.)+23.0% |
Total return · from 2023-02-03ⓘ Risk | Ann. volatility (1Y)120.3% | | Ann. volatility (3Y)100.3% | | Sharpe (1Y)1.27 | | Sharpe (3Y)0.65 | | Max drawdown (1Y)−61.7% | | Max drawdown (3Y)−81.0% | | Beta (3Y vs SPY)−1.95 |
Daily returns, ann.ⓘ Top institutional holders13F 2026-Q1 | Manager | Shares | Value | % sh out | QoQ |
|---|
| FMR LLC | 8.4M | $405M | 3.95% | −3.5% | | WELLINGTON MANAGEMENT GROUP LLP | 7.3M | $350M | 3.42% | +1.9% | | Avoro Capital Advisors LLC | 6.6M | $316M | 3.08% | +0.0% | | JANUS HENDERSON GROUP PLC | 5.4M | $258M | 2.52% | +5.2% | | Deep Track Capital, LP | 4.3M | $206M | 2.01% | +4.1% | | BVF INC/IL | 3.5M | $167M | 1.63% | −0.6% | | MORGAN STANLEY | 2.3M | $111M | 1.08% | +10.4% | | PRICE T ROWE ASSOCIATES INC /MD/ | 2.0M | $96M | 0.94% | +19.7% |
Δ vs 2025-Q4ⓘ Latest reported quarterslast report 2026-08-06 | Period end | Reported | EPS | EPS YoY | Revenue | Rev YoY |
|---|
| 2026-06-30 | 2026-08-06 | −$0.49 | — | — | — | | 2026-03-31 | 2026-05-07 | −$0.35 | — | — | — | | 2025-09-30 | 2025-11-06 | −$0.37 | — | — | — | | 2025-06-30 | 2025-08-06 | −$0.36 | — | — | — |
As-reported XBRL · next 2026-11-05 est.ⓘ Basis & disclosures - EOD closes · nothing imputed or averaged · absent “—”
- As-of differs by block · 13F = US long, 45+d lag, LOWER bound
- Not investment advice · no recommendation, price target or solicitation
- EDGAR + foreign registers · marketstack (licensed EOD) · spzco.com/methodology
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