Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-06-03 | Baker Brothers Life Sciences LP | Director | +Grant | 6,408 | — | — |
| 2026-06-03 | Baker Brothers Life Sciences LP | Director | +Grant | 6,408 | — | — |
| 2026-06-03 | Cook Jennifer E. | Director | +Grant | 6,408 | — | — |
| 2026-06-03 | Van Hauwermeiren Timothy | Director | +Grant | 6,408 | — | — |
| 2026-06-03 | Thornberry Nancy | Director | +Grant | 6,408 | — | — |
| 2026-06-03 | Schenkein David P | Director | +Grant | 6,408 | — | — |
| 2026-06-03 | Krognes Steve E. | Director | +Grant | 6,408 | — | — |
| 2026-06-03 | Klein Peter S | Director | +Grant | 6,408 | — | — |
| 2026-06-03 | FLATLEY JAY T | Director | +Grant | 6,408 | — | — |
| 2026-01-06 | Schuth Alexander O. | Officer | −Sell | 17,218 | $16.50 | $284,097 |
| 2026-01-06 | Watts Ryan J. | Director,Officer | −Sell | 35,198 | $16.50 | $580,767 |
| 2026-01-03 | Watts Ryan J. | Director,Officer | +Grant | 78,960 | — | — |
| 2026-01-03 | Schuth Alexander O. | Officer | +Grant | 57,700 | — | — |
| 2025-11-04 | Van Hauwermeiren Timothy | Director | +Grant | 10,632 | — | — |
| 2025-09-03 | Watts Ryan J. | Director,Officer | −Gift | 50,000 | — | — |
| 2025-08-13 | Ho Carole | Officer | −Sell | 806 | $14.64 | $11,800 |
| 2025-08-12 | Ho Carole | Officer | −Sell | 2,937 | $13.58 | $39,884 |
| 2025-08-12 | Schuth Alexander O. | Officer | −Sell | 2,937 | $13.58 | $39,884 |
| 2025-08-05 | Ho Carole | Officer | +Exercise | 44,655 | $0.68 | $30,365 |
| 2025-07-09 | Watts Ryan J. | Director,Officer | +Exercise | 455,282 | $0.68 | $309,592 |
| 2025-07-09 | Watts Ryan J. | Director,Officer | −Sell | 495,282 | $15.00 | $7M |
| 2025-07-09 | Watts Ryan J. | Director,Officer | +Exercise | 40,000 | $5.28 | $211,200 |
| 2025-06-03 | Tessier-Lavigne Marc | Director | +Grant | 6,037 | — | — |
| 2025-06-03 | Thornberry Nancy | Director | +Grant | 6,037 | — | — |
| 2025-06-03 | Schenkein David P | Director | +Grant | 6,037 | — | — |
| 2025-06-03 | Krognes Steve E. | Director | +Grant | 6,037 | — | — |
| 2025-06-03 | Klein Peter S | Director | +Grant | 6,037 | — | — |
| 2025-06-03 | FLATLEY JAY T | Director | +Grant | 6,037 | — | — |
| 2025-06-03 | Cook Jennifer E. | Director | +Grant | 6,037 | — | — |
| 2025-06-03 | BAKER BROS. ADVISORS LP | Director | +Grant | 10,565 | — | — |
| 2025-06-03 | BAKER BROS. ADVISORS LP | Director | +Grant | 10,565 | — | — |
| 2025-01-07 | Krognes Steve E. | Director | −Sell | 3,339 | $20.81 | $69,485 |
| 2025-01-07 | Watts Ryan J. | Director,Officer | −Sell | 7,650 | $20.81 | $159,197 |
| 2025-01-07 | Schuth Alexander O. | Officer | −Sell | 2,907 | $20.81 | $60,495 |
| 2025-01-07 | Ho Carole | Officer | −Sell | 2,907 | $20.81 | $60,495 |
| 2025-01-06 | Watts Ryan J. | Director,Officer | −Sell | 29,266 | $20.22 | $591,759 |
| 2025-01-06 | Schuth Alexander O. | Officer | −Sell | 12,255 | $20.22 | $247,796 |
| 2025-01-06 | Ho Carole | Officer | −Sell | 12,255 | $20.22 | $247,796 |
| 2025-01-03 | Ho Carole | Officer | +Grant | 54,180 | — | — |
| 2025-01-03 | Schuth Alexander O. | Officer | +Grant | 54,180 | — | — |
| 2025-01-03 | Watts Ryan J. | Director,Officer | +Grant | 54,180 | — | — |
| 2025-01-02 | SATO VICKI L | Director | −Sell | 3,080 | $20.91 | $64,403 |
| 2024-12-31 | Krognes Steve E. | Director | −Sell | 30,000 | $20.25 | $607,500 |
| 2024-12-27 | Schuth Alexander O. | Officer | +Exercise | 6,708 | $5.28 | $35,418 |
| 2024-11-25 | Ho Carole | Officer | +Exercise | 17,845 | $0.68 | $12,135 |
| 2024-11-22 | Schuth Alexander O. | Officer | +Exercise | 20,516 | $0.68 | $13,951 |
| 2024-11-11 | Schenkein David P | Director | −Sell | 32,312 | $32.87 | $1M |
| 2024-11-11 | Schenkein David P | Director | −Sell | 27,129 | $32.09 | $870,570 |
| 2024-11-11 | Schenkein David P | Director | +Exercise | 47,165 | $18.00 | $848,970 |
| 2024-11-07 | SATO VICKI L | Director | −Sell | 1,020 | $30.00 | $30,600 |
| 2024-11-07 | Schuth Alexander O. | Officer | +Exercise | 15,558 | $5.28 | $82,146 |
| 2024-11-07 | Schuth Alexander O. | Officer | −Sell | 300 | $31.29 | $9,387 |
| 2024-11-07 | Schuth Alexander O. | Officer | −Sell | 2,925 | $30.72 | $89,856 |
| 2024-11-07 | Schuth Alexander O. | Officer | −Sell | 12,333 | $29.68 | $366,043 |
| 2024-11-01 | SATO VICKI L | Director | −Sell | 3,080 | $27.07 | $83,376 |
| 2024-10-18 | Watts Ryan J. | Director,Officer | −Sell | 40,000 | $27.69 | $1M |
| 2024-10-18 | Watts Ryan J. | Director,Officer | +Exercise | 40,000 | $0.68 | $27,200 |
| 2024-09-30 | Krognes Steve E. | Director | −Sell | 30,000 | $29.03 | $870,900 |
| 2024-09-13 | SATO VICKI L | Director | −Sell | 1,020 | $30.00 | $30,600 |
| 2024-09-03 | SATO VICKI L | Director | −Sell | 100 | $25.37 | $2,537 |
| 2024-09-03 | SATO VICKI L | Director | −Sell | 2,980 | $24.99 | $74,470 |
| 2024-08-21 | Ho Carole | Officer | −Sell | 5,907 | $24.96 | $147,439 |
| 2024-08-21 | Ho Carole | Officer | −Sell | 14,098 | $24.41 | $344,132 |
| 2024-08-21 | Schuth Alexander O. | Officer | −Sell | 2,547 | $24.78 | $63,115 |
| 2024-08-20 | Ho Carole | Officer | −Sell | 2,453 | $23.79 | $58,357 |
| 2024-08-20 | Schuth Alexander O. | Officer | −Sell | 2,453 | $23.79 | $58,357 |
| 2024-08-20 | Schuth Alexander O. | Officer | −Sell | 3,353 | $23.54 | $78,930 |
| 2024-08-20 | Krognes Steve E. | Director | −Sell | 1,727 | $23.79 | $41,085 |
| 2024-08-20 | Watts Ryan J. | Director,Officer | −Sell | 2,260 | $23.79 | $53,765 |
| 2024-08-13 | Ho Carole | Officer | −Sell | 2,337 | $22.89 | $53,494 |
| 2024-08-13 | Schuth Alexander O. | Officer | −Sell | 2,272 | $22.89 | $52,006 |
| 2024-07-01 | SATO VICKI L | Director | −Sell | 2,980 | $22.12 | $65,918 |
| 2024-07-01 | SATO VICKI L | Director | −Sell | 100 | $22.86 | $2,286 |
| 2024-07-01 | Krognes Steve E. | Director | −Sell | 29,900 | $22.12 | $661,388 |
| 2024-07-01 | Krognes Steve E. | Director | −Sell | 100 | $22.80 | $2,280 |
| 2024-06-13 | Krognes Steve E. | Director | −Sell | 688 | $21.79 | $14,992 |
| 2024-06-06 | Cook Jennifer E. | Director | −Sell | 1,458 | $21.73 | $31,682 |
| 2024-05-31 | Klein Peter S | Director | +Grant | 5,967 | — | — |
| 2024-05-31 | Harris Erik | Director | +Grant | 5,967 | — | — |
| 2024-05-31 | FLATLEY JAY T | Director | +Grant | 5,967 | — | — |
| 2024-05-31 | Schenkein David P | Director | +Grant | 5,967 | — | — |
| 2024-05-31 | Cook Jennifer E. | Director | +Grant | 5,967 | — | — |
| 2024-05-31 | SATO VICKI L | Director | +Grant | 5,967 | — | — |
| 2024-05-31 | Tessier-Lavigne Marc | Director | +Grant | 5,967 | — | — |
| 2024-05-31 | Thornberry Nancy | Director | +Grant | 5,967 | — | — |
| 2024-05-31 | Krognes Steve E. | Director | +Grant | 5,967 | — | — |
| 2024-05-15 | SATO VICKI L | Director | −Sell | 1,674 | $20.39 | $34,133 |
| 2024-04-15 | SATO VICKI L | Director | −Sell | 1,666 | $18.29 | $30,471 |
| 2024-04-01 | Krognes Steve E. | Director | −Sell | 92,500 | $20.50 | $2M |
| 2024-03-29 | Watts Ryan J. | Director,Officer | −Gift | 40,000 | — | — |
| 2024-03-15 | SATO VICKI L | Director | −Sell | 1,666 | $20.10 | $33,487 |
| 2024-02-15 | SATO VICKI L | Director | −Sell | 1,666 | $18.37 | $30,604 |
| 2024-02-14 | Schuth Alexander O. | Officer | −Sell | 20,128 | $17.66 | $355,460 |
| 2024-02-14 | Ho Carole | Officer | −Sell | 1,405 | $17.79 | $24,995 |
| 2024-02-13 | Schuth Alexander O. | Officer | −Sell | 2,716 | $17.29 | $46,960 |
| 2024-02-13 | Ho Carole | Officer | −Sell | 2,784 | $17.29 | $48,135 |
| 2024-02-13 | Watts Ryan J. | Director,Officer | −Sell | 9,589 | $17.29 | $165,794 |
| 2024-02-13 | Krognes Steve E. | Director | −Sell | 2,750 | $17.29 | $47,548 |
| 2024-02-08 | Schuth Alexander O. | Officer | +Exercise | 50,000 | $0.68 | $34,000 |
| 2024-01-16 | SATO VICKI L | Director | −Sell | 1,666 | $18.42 | $30,688 |
| 2024-01-10 | Ho Carole | Officer | −Sell | 4,668 | $19.02 | $88,785 |
| 2024-01-09 | Watts Ryan J. | Director,Officer | −Sell | 7,818 | $19.78 | $154,640 |
| 2024-01-05 | Watts Ryan J. | Director,Officer | −Sell | 17,483 | $19.43 | $339,695 |
| 2024-01-05 | Schuth Alexander O. | Officer | −Sell | 9,972 | $19.43 | $193,756 |
| 2024-01-05 | Krognes Steve E. | Director | −Sell | 3,208 | $19.43 | $62,331 |
| 2024-01-05 | Ho Carole | Officer | −Sell | 9,972 | $19.43 | $193,756 |
| 2024-01-03 | Watts Ryan J. | Director,Officer | +Grant | 89,520 | — | — |
| 2024-01-03 | Ho Carole | Officer | +Grant | 53,720 | — | — |
| 2024-01-03 | Schuth Alexander O. | Officer | +Grant | 53,720 | — | — |
| 2023-12-15 | SATO VICKI L | Director | −Sell | 1,666 | $23.39 | $38,968 |
| 2023-11-15 | SATO VICKI L | Director | −Sell | 1,666 | $19.13 | $31,871 |
| 2023-10-16 | SATO VICKI L | Director | −Sell | 1,666 | $20.66 | $34,420 |
| 2023-09-15 | SATO VICKI L | Director | −Sell | 40 | $24.35 | $974 |
| 2023-09-15 | SATO VICKI L | Director | −Sell | 1,626 | $23.60 | $38,374 |
| 2023-08-23 | Ho Carole | Officer | −Sell | 2,522 | $23.22 | $58,561 |
| 2023-08-23 | Schuth Alexander O. | Officer | −Sell | 2,522 | $23.17 | $58,435 |
| 2023-08-21 | Krognes Steve E. | Director | −Sell | 1,419 | $22.60 | $32,069 |
| 2023-08-21 | Watts Ryan J. | Director,Officer | −Sell | 2,309 | $22.59 | $52,160 |
| 2023-08-21 | Schuth Alexander O. | Officer | −Sell | 2,478 | $22.59 | $55,978 |
| 2023-08-21 | Ho Carole | Officer | −Sell | 2,478 | $22.60 | $56,003 |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
